1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP
    Dismiss Notice

Effects - How does morphine compare to oxycodone and hydrocodone?

Discussion in 'Morphine' started by MonarchX, Oct 1, 2010.

  1. MonarchX

    MonarchX

    Reputation Points:
    -56
    Joined:
    Jun 1, 2010
    Messages:
    76
    Oxycodone is thebane based - stimulating, hydrocodone is codeine based - sedating. Where does morphine fit in? How is the high different?
     
  2. On The Nod

    On The Nod Silver Member

    Reputation Points:
    482
    Joined:
    Sep 7, 2008
    Messages:
    779
    Morphines Wack- wouldnt bother with it unless your super opiate intolerant the high is nice even orally but damm u need take more than your maintenace dose to get anything...

    never taken others..
     
  3. helikophis

    helikophis Gold Member

    Age:
    35
    Reputation Points:
    1,074
    Joined:
    Oct 28, 2008
    Messages:
    412
    Oxycodone is more stimulating and more euphoric, but much shorter-acting than morphine. Hydrocodone is similar in euphoria and soporific effects, but lasts considerably longer. Both oxy- and hydrocodone are significantly more bioavailable than morphine when taken orally - oral use of morphine is highly inefficient, compared to other commonly used opiates (I believe around 20% makes it to the bloodstream). Oral preparations of morphine come as salts, so they must be converted to freebase for smoking. Oxycodone and hydrocodone also come as salts, but they are relatively efficient for oral use, so there's less reason to freebase them.

    Morphine is most comparable in "high" and painkilling to codeine - codeine is not itself psychoactive - it is converted by the liver into active opiates, the main one being morphine. Morphine does tend to be tolerated better than codeine, with less allergic reactions and sub-allergic histamine problems (itching/rashes, etc). Also, only a certain amount of codeine can be handled by the liver at one time, so doses much over 400mg tend to be less and less effective. Morphine is also very similar to heroin - heroin is converted in the brain to morphine, and it is actually a morphine high that heroin users experience, but the structure of heroin gives it a much higher affinity for crossing the blood-brain barrier, meaning it hits harder and faster than morphine that hasn't been diacetylated.

    Hope that helps!
     
    Last edited: Oct 7, 2010
  4. iiyama

    iiyama Silver Member

    Age:
    55
    Reputation Points:
    29
    Joined:
    Jun 18, 2009
    Messages:
    26
    Thnk you Helikophis. I wasn't aware Oxycodone produced more of a stimulating effect than Morphine.

    Morphine, from my experience and in comparison with oral ingestion is more potent when it is used intravenously. That said, one has to be really, really carful when using Morphine whatever the route of administration.

    Regarding Oxycodone and Hydrocodone is it true one of these drugs is only available as a time released preparation ? I beleive in the UK either Oxycodone or Hydrocodone is made exclusively as a time released pill.

    LIke I said I'm not 100% sure but time relased pills will always produce a different effect to their instant release counterparts.
     
  5. Moving Pictures

    Moving Pictures Titanium Member

    Age:
    28
    Reputation Points:
    4,200
    Joined:
    Feb 4, 2010
    Messages:
    2,992
    You don't need to convert morphine to freebase to inject. If you did, you'd have to add an acid to form a salt so it disolves in water. Morphine salt disolves in water, freebase doesn't. Not tying to be rude or anything, it's just an important point to make.:)


    That's debatable. Some people find it more stimulating but plently of people find it just as sedating. All opiates in high doses are going to be sedating. It's typically when taken in lower doses that they're stimulating.

    The different effect is that they last longer than istant release. Also, time release are usually in higher doses than immediate release.
     
    Last edited: Oct 7, 2010
  6. helikophis

    helikophis Gold Member

    Age:
    35
    Reputation Points:
    1,074
    Joined:
    Oct 28, 2008
    Messages:
    412
    Whoops, my mistake. Think a couple of ideas got jammed together there. Editing the post! Thanks for pointing that out.
     
  7. MadOne

    MadOne Mercury Member

    Reputation Points:
    -55
    Joined:
    Nov 1, 2011
    Messages:
    190
    Morphine is more euphoric imo to me but does has a low oral absorbtion rate requireing slightly larger doses than oxycodone orally on most people but iv morphine is stronger than iv oxycodone in most people.
    Both oxycodone and hydrocodone are normally extracted from thebaine that i think is sourced mainly from the iranian poppy now as it contains a lot of thebaine. it makes no financial sense to source thebaine from the opium poppy now they now how much thebaine the iranian poppy yeilds around 25-30% w/v . makes a lot more financial sense to me to use different poppys for making oxycodone,oxymorphone,hydromorphone and hydrocodone with those potential yeilds. i know in the past a lot of the medicinal codiene was made from converted morphine due to the opium poppys low codeine content. seems a waste to me that lol I would prefer to be able to buy paracetamol n morphine otc than its inferior little brother they wasted there time there gimmie 12mg of morphine in otc apap mix anyday than weak old codeine. i assume it must be possible to convert thebaine to codeine too.