Inclination for addiction to certain chemicals ?

Discussion in 'General Addiction discussion' started by Klaus, Jan 8, 2007.

  1. Klaus

    Klaus Newbie

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    I am interested to learn if there are any rats out there who have found that they become dependent on any particular substance easier than others ?

    I am meaning serious physical dependence .

    I have found that he becomes dependent on ANYTHING that it is POSSIBLE to become PHYSICALLY DEPENDENT on very easy.

    There is a reason for swims disposition.

    My first addiction was Alcohol and when it came to stopping had full DT's and convulsions.

    Thankyou.
     
  2. monkeygone2heaven

    monkeygone2heaven Titanium Member

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    from U.S.A.
    there two facts are well established:

    - being prone to addiction in general has some genetic basis
    - there is a lot of individual variability in receptor distribution, subtype distribution and other receptor properties for various substances (e.g., nicotine, dopamine, serotonin) -- most of these are also known to be genetic.

    therefore we are all more or less likely to be addicted to certain things (our "poisons") by nature.

    it is also known that these genetic factors are triggered into full-blown addiction by environmental stressors later on in life (even in animals)

    there is so much literature in this, so just a few of the most recent abstracts:

    general review of genetics and dopamine:
    http://www.ncbi.nlm.nih.gov/entrez/..._uids=17063402&query_hl=2&itool=pubmed_docsum


    specifically about alcohol:
    http://www.ncbi.nlm.nih.gov/entrez/...Retrieve&dopt=abstractplus&list_uids=15520362

    http://www.ncbi.nlm.nih.gov/entrez/..._uids=16961765&query_hl=2&itool=pubmed_docsum

    http://www.ncbi.nlm.nih.gov/entrez/...Retrieve&dopt=abstractplus&list_uids=16499479
     
  3. Klaus

    Klaus Newbie

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    Thankyou for the links Monkey. Thankfully I has no dependence (at the moment ) but as stated finds it VERY easy to become so.