Increasing mescaline potency

Discussion in 'Peyote & San Pedro' started by jaguarangel, Dec 14, 2005.

  1. jaguarangel

    jaguarangel Newbie

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    Apr 10, 2005
    from U.S.A.
  2. IHrtHalucingens

    IHrtHalucingens Palladium Member

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    Sep 24, 2005
    31 y/o
    I do not know of any specific human study that has explored this combination. The primary active component of peyote is mescaline, and this alkaloid is known to undergo oxidative deamination in man. Jumex (Selegeline, l-deprenyl) is known to be an inhibitor of monoamine oxidases. It is a weak reversible inhibitor of the MAO-A and a strong irreversible inhibitor of MAO-B.

    In man, a major metabolite of mescaline is the pharmacologically inactive compound 3,4,5-trimethoxyphenylacetic acid. This is a product of oxidative deamination, and it is certainly possible that Jumex could inhibit its formation. It is reasonable, then, that less mescaline would be inactivated and thus there would be a higher blood level from a fixed dose. Thus a normal dose might constitute an overdose if there was inhibition of the formation of this metabolite. Further, there are a couple of other phenethylamines known to accompany mescaline in the peyote cactus. Their activities remain largely unstudied in man, but if any of them are intrinsically active but remain ineffective due to the amine oxidases, they might well complicate your experience.