I found something on another forum about intravenous use of zolpidem (Ambien) and found that he was immediately fascinated by the idea. Due to the rules here he can't post a link to the thread on the other forum. However, here's a small portion of several posts on the thread: I thought this topic interesting and worthy of discussion, particularly given the fact that Zolpidem is *very short acting* and nearly all psychoactive drugs in that category have abuse potential. Note that IV'ing pills is very dangerous unless one knows a certain technique to remove all pill binders, fillers, etc. and end up with only the pure drug remaining. Unless you have the proper lab gear and know how, don't do it. Don't even think about doing it. That said -- if anyone's tried it, please pipe up with (A) how you isolated the zolpidem from Ambien tablets, and (B) what you found in terms of effects.