Discussion in 'Pharmacology' started by sands of time, Jun 12, 2004.
Is caffiene a dopamine antagonist like other stimulents?
i think but slightly... like only in certain people... it effects me... but it wont bring me out of a bad mood... but it will help me if i am already... so i think its only slightly... i dont know a whole lot tho so...anyone else?
No, its an agonist.
Not an agonist at all, tho it releases small amounts of dopamine and noradreline by antagonizing adenosine (the hormone that stopts dopamine/adrenaline release and makes you sleepy).
In that case wouldn't it be a partial-agonist? Anyhoo, here's a load of stuff about caffeine from those lovely people at Wikipedia!
RG said it right - it does not directly produce dopamine. This
can be "proven?" with a simple experiment. Go take as many
wakeups as you dare say 5? (500mg of caffine) with nothing else.
You will be perky, nausous, and paranoid but not high. Caffine is
essentialy non-euphoric. It can be a pickup but not much
It works by blocking the effects of adenosine which is produced by
cells exhausting there ATP supply (a fairly universal energy token used
by almost all living cells). ATP (adenosine triphosphate) is
converted to ADP (di-phos.) then AMP (mono-phos.) then finaly
adenosine. Typicaly high adenosine levels are a sign of
exaustion, poor blood flow, lack of O2, etc. all signs you should slow
down and get some rest. Since this system influences other
systems but does
controll any vital life function itself, caffine is a relitivly safe
fairly forgiving overdoeses and withdrawls (as compared to drugs that
the dopamine system). Your body also adapts to it quickly as
well, 3 days being all that is required to be rid of physical withdrawl
symtomes (or develop a 10 cup of joe a day habit)
Edited by: Nitrate
From Gold Standard Media's Clinical Pharmacolgy: