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Combinations - Is trazodone and diphenhydramine a safe combination for sleep?

Discussion in 'Drug combinations' started by Orchid_Suspiria, Aug 30, 2007.

  1. Orchid_Suspiria

    Orchid_Suspiria Newbie

    Reputation Points:
    Feb 10, 2007
    39 y/o
    I was wondering if 125 mg's of diphenhydramine and 50 mg's of trazodone would be a safe combination to get to sleep?Do any swiy's have any experience with this combination?
  2. pixplzthx

    pixplzthx Newbie

    Reputation Points:
    Jun 28, 2007
    from afghanistan
    Well.... Based on the information available to me (google), I'd just recommend calling a pharmacy.

    No, Really. I've done it. They love to answer questions.

    My concern is whether or not the moderate (to none) SSRI effects of either drug would expo-tentiate (exponentially potentiate, I just made that up). Based on what I'm reading (at Wiki and rxlist) that shouldn't happen.

    But when you are dealing with death, it never hurts to ask a professional.

    Also, they act on different areas of the brain. Trazodone is acting on the 5-HT receptor and diphenhydramine is acting on histamine h-1 receptor.
    Last edited: Sep 6, 2007
  3. kareena

    kareena Newbie

    Reputation Points:
    Jun 15, 2007
    As pixplzthx says it couldn't hurt to call a pharmacy...
    I wouldn't expect that combo to cause any problems though, I have used higher than therapeutic doses of diphenhydramine with mirtazapine (remeron) without consequence (other than the desired: sleep). I know mirtazapine isn't trazodone but they do have some similar mechanisms of action.
    Last edited: Sep 7, 2007