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Drug info - JWH-018 (1-Pentyl-3-(1-Naphthoyl)Indole)

Discussion in 'Cannabinoids' started by sg43, Nov 21, 2008.

  1. sg43

    sg43

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    Please post info about JWH-018 here.
    Can anyone add information about:
    • names / synonyms
    • molecule
    • dose
    • duration
    • side effects
    • have there been any reported incidents with this compound?
    • since when has this research chemical been available?
    • legal status
    • stability of the molecule / compound
    Experiences with JWH-018 should be posted here: JWH-018 Experiences

    The toxicity of JWH-018 has been studies and published here on drugs-forum. Please see here:
    JWH-018 (Spice) ADME Toxicology Studies & Discussion

    Our extensive [wiki=90909]JWH-018[/wiki] WIKI gives additional information.
    See here for all threads about JWH-018.


    Also see our Cannabinoid index.

    Taken from another source:

    Also there was a picture along with this info but it linked back to a website so I have attached it to this post.

    Several grams of JWH-018:
     

    Attached Files:

    Last edited by a moderator: Aug 28, 2009
  2. nibble

    nibble Titanium Member

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    Swim has procured some of this interesting compound (I think some of you know where ;)) and will do a trip report as soon as he begins his research. Swim has just a small amount at his disposal, about 12mg give or take so about 4-5 doses worth.

    A magical pony told me the following:
     
    Last edited by a moderator: Feb 3, 2010
  3. cosmicruler

    cosmicruler Silver Member

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    swim has tried,appearance was a bit more yellow than that above rusty photo...pleasant,slight euphoric feeling,no body load at all at 2-5mg eyeblled,smoked through a bong,by blocking with tiny amount of 'skunky goodness'...

    swim has seen a friend consume roughly 5-15mg and had severe anxiety related issues/possible panic attack,but was fine after about 20-30 minutes...
    maybe good idea for those without accurate scales to have a benzo handy...??

    it has quite a weird smell,slighly ammonia like...

    does any1 know if this is h2o or alcohol soluble??
     
  4. Alfa

    Alfa Productive Insomniac Staff Member

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    FUBAR's first information on this has confirmed that quality is indeed low. FUBAR has seen a CoA.
     
  5. nibble

    nibble Titanium Member

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    Any chance you could give us a summary of what was in this CoA? Were specific impurities found, if so what? Just a bit curious about this now.

    Where were you getting your information Alfa? Because information that has come to light recently would show that this compound should absolutely not be a white-yellow powder and a tan solid somewhat like the picture is in fact the correct form, MSDS for the compound back this up, along with info from a friend with good chemistry knowledge. Based on the molecular structure of the compound it would suggest that it would indeed be coloured and not white.

    But other info on potential toxicity of this mediated by its possible metabolism to naphthalene have put SWIM off further testing regardless. Also there is just about nothing known about this in general, there could well be other interactions besides CB1 and CB2 modulation, we simply don't know. IIRC JWH-015 has been proven to have naphthalene epoxides as metabolites..
    I don't know guys, there's just too little research done with this for SWIM.
     
    Last edited by a moderator: Feb 3, 2010
  6. Alfa

    Alfa Productive Insomniac Staff Member

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    FUBAR does not know what was on the CoA except 96.6 - 97% purity, which FUBAR considers pretty low.

    Well FUBAR has seen white-yellow jwh-018 with 99.6% purity, but has also seen clear slightly yellow oil(which was not turned into a salt yet). So if yellow-white crystals are already available and if clear yellow oil is already available, then the picture speaks for itself.
     
  7. nibble

    nibble Titanium Member

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    Ah, had no idea myself really, I didn't really think you could in fact do that though..

    And the above doc from Huffman doesn't mention the appearance of JWH-018 at all, the only place that chem is mentioned is in relation to its affinity for cb1/cb2. Right Alfa, hmm SWIM is very confused about the whole issue, other sources state it as being a tan solid in its ketone form, SWIM really doesn't know, not saying you're not a credible source Alfa but I don't see why the other source would be any less credible..
    Unless we see a doc from Huffman et al describing the synth/appearance of final product I don't think we could be truly sure.
     
  8. Quantum Dude

    Quantum Dude

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    Well, I got something which is really close, the only difference is an extra methyl group. Look at page 544, bottom right of the page

    1-Pentyl-3-(4-methyl-1-naphthoyl)indole (15).

    ......The solvents were removed in vacuo to give a yellow oil
    which was purified by chromatography to give 0.24 g
    (42%) of 1-Pentyl-3-(4-methyl-1-naphthoyl)indole as a pale yellow oil


    http://www.drugs-forum.com/forum/local_links.php?action=jump&catid=52&id=6260


    Although a strong correlation can be made since it differs from a methyl group, its not the actual compound, the original synthesis of JWH-018 is here , but I cant have access to it :(.
     
    Last edited by a moderator: Jan 29, 2010
  9. nanobrain

    nanobrain Platinum Member

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    um, if i am not mistaken, the picture above and descriptions following are of one of the earlier gone but not forgotten finished form smoking preparations incorpporating the JWH as the active, the rest of the matrix being apple hookah smokin flavorin' ;-)

    its for rolling yummy joints and only a small percentage of jwh which is an offwhite solid is incorporated.
     
  10. Alfa

    Alfa Productive Insomniac Staff Member

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    Re: Legality of spice and spice gold

    I have received the following text by email. A Canadian smoke blend dealer asked his lawyer for advise. This is the result:

    There has been some discussion about this before. A member here, that studies law, dug into this, even inquired with his professor and came to the same conclusion.
     
    Last edited: Dec 18, 2008
  11. mouse99

    mouse99

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    A series of pre-clinical ADME/Toxicity studies were conducted on JWH-018 including CYPs, Genotox, hERG, Cytotox, Rodent Tox (LD50, Acute Dose, Repeat Dose & Pharmakinetics). All tests passed within tolerable guidelines. JWH-018 tested negative for genotox (ie cancer) using standard GreenScreen HC both with and without S9 (fraction from liver hepatocytes which metabolizes compounds and looks for genotoxic metabolites).

    Further detailed information is forthcoming.
     
  12. mictihtoya

    mictihtoya Silver Member

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    At 98% purity, JWH-018 is a neon yellow waxy crystalline substance that looks a bit like DMT, and a bit like bee pollen. At 99% purity it should be white to off-white crystals.

    The rust brown shit being sold openly via the web is very impure shit and possibly hazardous for all anyone really knows.
     
  13. Rendezvous

    Rendezvous

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    Sorry to side track, but I feel this needs to be addressed:

    Based on WHAT evidence? I've seen this topic discussed on a couple other forums and your statement is entirely based on the speculation of one or two people who have merely looked at a picture, and that's literally it. They might be intelligent dudes, but I think they might just be jumping too quick to conclusions.

    Here's some facts you may have missed: No one anywhere has produced any hard evidence to prove those accusations. A chemist in another forum actually did a NMR and HPLC on a sample of that brown compound and it passed. Another guy produced a CoA and it passed > 98% purity. And those who have actually tried it have reported no complaints, including myself.

    BTW, SWIM put some in my herb grinder and it came out as a waxy yellow powder just like what you described above. :thumbsup:
     
    Last edited by a moderator: Jan 11, 2010
  14. sarbanes

    sarbanes

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    it's better than most cannabis, but doses need to be kept low 200-500mics.
     
    Last edited by a moderator: Feb 3, 2010
  15. 2psychonauts

    2psychonauts Newbie

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    The package of JWH-018 arrived Saturday night. The product resembles what has been sold as 'red-rock opium' (Dragon's Blood Incense), but has a softer, waxy texture as opposed to DB Incense's hard, crunchy texture. It has a distinct flowery/chemical scent to it.

    No mg scale around, we very carefully shaved off 3-5 mg of product (when not condensed into a 'rock', the product looks light yellow) and inserted it into an indirect heating/oil pipe (bubble pipe). Keeping the flame under the product, it melted and began boiling/smoking. Inhaled all subsequent vapors in one breath. It has a distinct flavor reminiscent of N,N,DMT.

    This was a virgin experience (no other drugs) and we definitely felt the effects of the chemical. Very pleasantly surprised. Our experiences with 'Spice Gold' and Spice-alikes were relatively minor; a feeling that it is similar to, but weaker than marijuana. 018 is serious business and we were significantly intoxicated. The equivalent of a gram-sized blunt of high-grade marijuana, although different... The fact that you need only one hit to ingest a rather large amount of this substance creates a bit of a 'rush' when the chemical comes on (roughly 2-5 minutes after ingestion), very much like the rush accompanied by an insufflated application of a strong opiate. Conversation was stimulated; slightly manic, though euphoric. A bit of the paranoia/anxiety that reminds us of early marijuana experiences.

    Around ten minutes later we began to notice that colors were very vibrant and full, as if on the verge of coming onto a low dose of psychedelics, but not quite tripping. As the rush subsides, we fell into a distinct heaviness; a sense that all of our limbs were roughly 10 pounds heavier and if we held very still, we could feel the 'buzzing' or 'humming' that accompanies a good psychedelic experience. Other than color-enhancement, no other psychedelic properties were noticed. Extreme sedation was noted after the one hour mark (reminiscent of benzodiazapine experiences, could possibly be used as a withdrawl aid), and we doubt that any further applications of the chemical would enhance the psychedelic properties inherent. More likely, the test subject would fall asleep.

    Dosage was repeated over a total of three times each for the rest of the night. Definite respiration suppression, we feel we have to consciously control our breathing. A little worrying, so we halted any more applications for the night. Normal respiration acquired roughly one hour after symptoms were first noted.

    Our effects while under the influence are:
    CNS depression(?) / respiration suppression,
    sedation,
    color enhancement or 'fullness',
    physical 'buzzing' or 'humming' sensation accompanied With 'heaviness',
    anti-depressant qualities (euphoria),
    mild paranoia/jumpiness (very mild anxiety),
    time dilation,
    analgesia,
    and nausea(?).

    Possible 'hangover' effects are:
    dry sore throat,
    mild headache,
    mild diarrhea,
    insomnia,
    and lethargy.

    Possible medical uses are:
    hunger aid,
    sleep aid,
    anti-depressant,
    pain-killer,
    withdrawal aid,
    and anti-anxiety (although there is a slight amount of paranoia or anxiety attributable to the experience, the sedation and euphoric quality of this substance are marked enough so it would make for a suitable anti-anxiety medication).

    This is a quality substance that is well-suited as a marijuana replacement. With regular usage, tolerance builds very slowly and possibly plateaus. Negative side-effects are minimal and the experience itself is largely pleasurable. Neither subject noticed any addiction/withdrawal symptoms with abrupt discontinuation of applications after seven days of consumption.

    This substance is far cheaper than marijuana 'hit-for-hit'.
     
    Last edited by a moderator: Mar 22, 2009
  16. Synchronium

    Synchronium Silver Member

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    That paper is attatched, but it doesn't seem to detail any kind of synthesis whatsoever.
     

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  17. Joe-(5-HTP)

    Joe-(5-HTP) Palladium Member

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    Swim will be getting his hands on some JWH-018 soon but wants to know how to store it and how long it will last. Will the purity affect this?

    Swim found this information on a website (which is also a source so he can't give the original link)

    Any swimmers have information about non-solution storage shelf life?
     
  18. Alfa

    Alfa Productive Insomniac Staff Member

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    I am wondering how people are measuring it, as a milligrams scale will not cut it and I doubt that many are going to buy a very expensive scale.

    The experimentation of people on various forums and their experiences are shocking to me. To measure this compound you either need a sub-milligram scale or measure a larger amount and homogeneously mix it and then ration it up. Failing to use either a sub-milligram scale or homogeneous mixing results in either under or over-dose.

    There is an ADME study available here on this forum, which includes a rat toxicity test. Assuming that the test is correct (which seems to be the case), this gives a clear outline of what dose is (relatively) safe and what dose is dangerous.

    I have read accounts of people taking unmeasured doses and doses up to 150mg JWH-018, due to inaccurate measuring. To put this into perspective: this is way beyond the danger zone. The fact that one person lives to see another day, does not mean that other persons will. The rats in the rat toxicity study started dying well below this level.

    I much understand that a sub-milligram scale is expensive (though really much cheaper than ever before), but it is a real nessecity.
     
    Last edited by a moderator: Feb 3, 2010
  19. Rendezvous

    Rendezvous

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    I don't understand this discussion about sub-milligrams, wasn't the human dosage stated to be around 3 to 4 mg? Any decent mg scale can handle that quantity.
     
  20. snapper

    snapper Gold Member

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    JWH-018 is soluble in (presumably) a non polar solvent. Dossolving a measured dose (say 10 mg) in a measured amount of solute (say 10 ml) gives a very accuate way of measuring without a ridiculously expensive scale that needs frequent calibration and cleaning. The question is what solvent to use. SWIM will check into solubility of this compound and report back. JWH-018 is soluble in ethanol (pure) at 10mg/ml from one source. SWIM thinks it could be dissolved in water (pure) as well at a higher concentration, but is probalby less stable over time. The dissolved product can be measured out, evaporated and ingested, even saturated into a known concentration of smokable material. Oh, wait, someone already did that with spice...