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JWH-018

Discussion in 'Drug Articles' started by Shampoo, Jun 8, 2009.

  1. Shampoo

    Shampoo entity of sorts Staff Member

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    JWH-018 is a synthetic cannabinoid that binds CB1 and CB2 receptors, with a moderate selectivity for the CB2 receptor and produces effects consistent with naturally occuring cannabinoids with THC. Dr. John W. Huffman first synthesized it, and it has been found in herbal smoking blends like Spice.

    [h="1"]Introduction to JWH-018 (1-pentyl-3-(1-nahpthoyl)indole)[/h]
    [imgr=white] http://www.drugs-forum.com/forum/attachment.php?attachmentid=21218&d=1310117012[/imgr]JWH-018 (1-pentyl-3-(1-naphthoyl)indole) is a synthetic aminoalkylindole Cannabinoid agonist which acts at both the CB1 and CB2 receptors, with a moderate selectivity for the CB2 receptor [footnote=ref1]Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60 133-140 (2000).[/footnote]. It is covered by US patent #7241799 [footnote=ref35]Makriyannis, Alexandros, and Hongfeng Deng. Cannabimimetic indole derivatives. University of Connecticut, assignee. Patent 7241799. 2007.[/footnote]

    Synthesized primarily for radioligand binding studies, JWH-018 (named after it's creator, John W. Huffman) has shown in vivo and in vitro activity [footnote=ref1]Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60 133-140 (2000).[/footnote] similar to that of the classic exogenous agonist of Cannabinoid receptors, ∆-9-THC, though it is considerably (4-5x) more potent [footnote=ref5]Stafford, Ned. "Synthetic cannabis mimic found in herbal incense." Advancing the Chemical Sciences. 15 Jan. 2009. RSC. 10 June 2009 <http://www.rsc.org/chemistryworld/News/2009/January/15010901.asp>.[/footnote].

    [h="1"]Using JWH-018[/h]
    In progress

    [h="2"]Routes of Administration[/h]

    [h="3"]Topical[/h]
    [h="3"]Internal[/h]
    [h="3"]Parenteral[/h]

    [h="2"]Tolerance[/h]
    JWH-018 exhibits a traditional tachyphylactic response in repeated dosing, with a notable decrease in both effect and duration after 3 days of chronic dosing [footnote=ref8]Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote]. This tolerance is likely the result of CB1/2 receptor downregulation, similar to the tolerance developed from ∆-9-THC or Cannabis administration as discussed here under the Tolerance heading and in much greater detail in a dedicated thread here: Cannabis and Cannabinoid Tolerance.

    [h="1"]Pharmacology and Pharmacokinetics of JWH-018[/h]

    [h="2"]Enzyme Inhibition by JWH-018[/h]
    JWH-018 has been shown to inhibit the following enzymes:

    - CYP1A2 (at 20.7% the potency of the reference compound, alpha-naphtoflavone) [footnote=ref11]Mouse99. JWH-018 CYP450 Inhibition. Raw data. Netherlands. 18 Dec. 2008.[/footnote]
    - CYP2C9 (at 7.1% the potency of the reference compound, sulphaphenazole) [footnote=ref11]Mouse99. JWH-018 CYP450 Inhibition. Raw data. Netherlands. 18 Dec. 2008.[/footnote]
    - CYP2C19 (at 357.1% the potency of the reference compound, tranylcypromine) [footnote=ref11]Mouse99. JWH-018 CYP450 Inhibition. Raw data. Netherlands. 18 Dec. 2008.[/footnote]
    - CYP3A4 (at 0.625% the potency of the reference compound, ketoconazole) [footnote=ref11]Mouse99. JWH-018 CYP450 Inhibition. Raw data. Netherlands. 18 Dec. 2008.[/footnote]

    [h="2"]Cannabinoid Receptor (CB1/CB2) Binding of JWH-018[/h]

    The Ki (binding affinity) values for primary cannabinoid (CB1/CB2) receptors are 9.00±5.00 and 2.94±2.65 nM, respectively, showing a general selectivity for the CB2 receptor over the CB1 receptor. The Ki ratio for the receptors is thus CB1:CB2, 3.06 [footnote=ref1]Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60 133-140 (2000).[/footnote].

    [h="2"]Molecular Pharmacology of JWH-018[/h]
    Though based on the structure of WIN 55,212-2, the JWH analogues lack a methyl group at C-2. Various N-Alkyl side chains define the various JWH analogues, which range from N-Propyl (JWH-072) to N-Hexyl (JWH-019) and of course N-Pentyl (JWH-018). The N-Pentyl substitute on the compound reduced CB2 selectivity as compared to N-Butyl substitute (JWH-073, which has a CB1:CB2 affinity ratio of 0.23) [footnote=ref1]Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60 133-140 (2000).[/footnote].

    In terms of the structure-activity-relationship (SAR) between CB receptors and their ligands, some primary components are necessary for a best-fit-alignment scenario: the cyclohexene and naphthalene ring, the phenolic hydroxyl and carbonyl group, the carbon side chain at C-3 and the morpholinoethyl group. In the case of JWH-018, the morpholinoethyl group has been replaced with the N-Pentyl side chain, which exhibits similar steric and electrostatic properties as the morpholinoethyl group [footnote=ref1]Aung, M.M., Griffin, G., Huffman, J.W., et al. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug and Alcohol Dependence 60 133-140 (2000).[/footnote].

    N-Alkyl chains of increasing length have been shown to increase binding affinity to CB2 receptors, and are maximized by the 4 and 6 carbon chains of JWH-018, JWH-007, JWH-048, JWH-081 and JWH-098 [footnote=ref3]J.L Wiley, D.R Compton, D Dai, J.W Huffman and B.R Martin, Structure-activity relationships of indole and pyrrole-derived cannabinoids, J. Pharmacol. Exp. Ther. 285 (1998), pp. 994–1004.[/footnote]. Compounds with shorter carbon chain lengths exhibited weak binding affinities and no in vivo activity (JWH-070, JWH-077, and JWH-043), as has also been shown with other CB agonists [footnote=ref4]D.R Compton, K.C Rice, B.R De Costa, R.K Razdan, L.S Melvin, M.R Johnson and B.R Martin, Cannabinoid structure-activity relationships: correlation of receptor binding and in vivo activities, J. Pharmacol. Exp. Ther. 265 (1993), pp. 218–226.[/footnote].

    [h="2"]Metabolism of JWH-018[/h]
    No accumulation of JWH-018 in peripheral tissues or albumin deposits was shown after 7 days of chronic dosing [footnote=ref8]Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote]. Bi-phasic distribution was shown for JWH-018 metabolism, suggesting that the drug undergoes both metabolism and elimination phases [footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote].

    [h="2"]Half-Life of JWH-018[/h]
    The half-life of JWH-018 is approximately two hours (112.2min) [footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote].

    [h="1"]Dangers of JWH-018[/h]

    [h="2"]Cardiovascular[/h]

    JWH-018 has been shown not to bind to hERG, the human gene encoding for cardiovascular potassium channels [footnote=ref12]Mouse99. hERG: In vitro Test For The Potential of QT Interval Prolongation by JWH-018. Raw data. Netherlands. 18 Dec. 2008.[/footnote]. It is thus unlikely to cause an increased QT interval, which could have deleterious and possibly deadly effects on the cardiovascular system.

    At the highest tested laboratory dose (10mg/kg) some respiratory depression was shown, which resulted in some animal deaths [footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote][footnote=ref8]Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote]. The deaths were attributed to catatonia and respiratory depression, as no organ toxicity was detected.

    [h="2"]Cytotoxicity[/h]

    JWH-018 has been shown not to cause direct cell-death [footnote=ref10]Mouse99. JWH-018 Cytotoxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote].

    [h="2"]Carcinogenic/Mutagenic Properties[/h]

    JWH-018 has been shown not to interfere with DNA in vivo. The combustion products of the material are still unknown and have not been tested for potential mutagenic or carcinogenic properties, but P.O. administration has been shown to not result in genotoxicity [footnote=ref9]Mouse99. JWH-018 Genotoxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote].

    [h="2"]Sensitivity[/h]

    Male rats have been shown to possess greater sensitivity to JWH-018 than their female counterparts [footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote][footnote=ref8]Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote]. This may potentially translate to an increased sensitivity in male humans as compared to females, though abnormalities in CB1/CB2 receptor distribution in male and female rats have been demonstrated in previous studies [footnote=ref8]Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.[/footnote].

    [h="1"]Producing JWH-018[/h]

    John W. Huffman has been quoted as saying that, "It [JWH-018] is really easy to make"[footnote=ref5]Stafford, Ned. "Synthetic cannabis mimic found in herbal incense." Advancing the Chemical Sciences. 15 Jan. 2009. RSC. 10 June 2009 <http://www.rsc.org/chemistryworld/News/2009/January/15010901.asp>.[/footnote]. A synthesis of the related compounds can be found in paper entitled "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists" [footnote=ref36]Huffman et al. "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB1 and CB2 receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB2 receptor agonists." Bioorganic and Medicinal Chemistry (2005): 89-112.[/footnote].

    [h="1"]Forms of JWH-018[/h]

    [h="2"]Pure JWH-018[/h]

    [h="3"]Chemical characteristics[/h]

    Column 1 Column 2
    0 Systematic (IUPAC) name: naphthalen-1-yl(1-pentyl-1H-indol-3-yl)methanone
    1 Synonyms: AM678, 1-pentyl-3-(1-naphthoyl)indole
    2 Molecular Formula: C[sub]24[/sub]H[sub]23[/sub]NO
    3 Molar mass: 341.45 g/mol [2]
    4 CAS Registry Number: 209414-07-3
    5 Melting Point: 51.9 °C [1]
    6 Boiling Point:
    7 Flash Point: no data
    8 Solubility:
    9 Additionnal data:
    10 Notes: aspect : off-white powder [1]


    Solubility in water: Not soluble in water at 25ºc [footnote=ref2]Cayman Chemical Company. Material Satefy Data Sheet- JWH-018. Brochure. Ann Arbor, MI: Author, 2009.[/footnote]
    Soluble in nonpolar solvents: Soluble in DMF (dimethylformamide), DMSO (dimethyl sulfoxide), EtOH (ethanol)[footnote=ref2]Cayman Chemical Company. Material Satefy Data Sheet- JWH-018. Brochure. Ann Arbor, MI: Author, 2009.[/footnote]
    Ion classification: 1 (Highly Ionizable)[footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote]

    [h="3"]Appearance[/h]

    White solid [footnote=ref6]Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.[/footnote][footnote=ref7]Mouse99. JWH-018 Analysis. Raw data. Netherlands. 18 Dec. 2008.[/footnote]
    Note: The degradation of indole compounds such as JWH-018 results in a yellow-brown, gummy appearance due to melting point suppression [footnote=ref33]http://www.drugs-forum.com/forum/sho...04&postcount=6[/footnote]. Samples of JWH-018 circulating as a gummy, rust-brown solid are highly oxidized samples of the compound, though appear to have degraded less than 5% [footnote=ref34]http://www.drugs-forum.com/forum/sho...374#post614374[/footnote].

    [h="2"]Spice[/h]

    Spice, Spice Silver, Spice Gold, Spice Diamond, Spice Tropical Synergy and Spice Arctic Synergy have all been confirmed in at least some analysis to contain JWH-018 [footnote=ref22]THC Pharm Analysis. Raw data. Main, Frankfurt. 15 Dec. 2008.[/footnote], though not always as the only or primary active ingredient [footnote=ref22]THC Pharm Analysis. Raw data. Main, Frankfurt. 15 Dec. 2008.[/footnote][footnote=ref23]EMCDDA Action on new drugs briefing paper: Understanding the Spice phenomenon. Publication. Lisbon, 2009.[/footnote][footnote=ref24]Sie, Lesen. "Gefährlicher Kick mit "Spice"" Frankfurter Rundschau 2009. 10 June 2009 <http://www.fr-online.de/frankfurt_und_hessen/nachrichten/frankfurt/1646010_Gefaehrlicher-Kick-mit-Spice.html>.[/footnote][footnote=ref25]http://www.drugs-forum.com/forum/showthread.php?t=73649[/footnote].

    [h="2"]Other JWH-018 containing herbal blends[/h]

    [h="3"]Confirmed[/h]

    Buddha Melt [footnote=ref26]http://www.drugs-forum.com/forum/showthread.php?t=85201[/footnote]
    Buddha Blend [footnote=ref27]http://www.drugs-forum.com/forum/showthread.php?t=86350[/footnote]

    [h="3"]Speculated[/h]

    Smoke X, XX, & XXX [footnote=ref28]http://www.drugs-forum.com/forum/showthread.php?t=83048[/footnote]
    Chillin XXX [footnote=ref29]http://www.drugs-forum.com/forum/showthread.php?t=44182[/footnote]
    Spicey XXX [footnote=ref30]http://www.drugs-forum.com/forum/showthread.php?t=60209[/footnote]
    ZoHai SX [footnote=ref31]http://www.drugs-forum.com/forum/showthread.php?t=50857[/footnote]
    Eclipse [footnote=ref32]http://www.drugs-forum.com/forum/showthread.php?t=25560[/footnote]
    ChillinMix [footnote=ref32]http://www.drugs-forum.com/forum/showthread.php?t=25560[/footnote]
    Smoke Plus [footnote=ref32]http://www.drugs-forum.com/forum/showthread.php?t=25560[/footnote]
    D-Raw [footnote=ref32]http://www.drugs-forum.com/forum/showthread.php?t=25560[/footnote]
    Skunk ANBow [footnote=ref32]http://www.drugs-forum.com/forum/showthread.php?t=25560[/footnote]

    [h="1"]The legal status of JWH-018[/h]

    [h="2"]Argentina[/h]

    JWH-018 has attracted negative government attention in Argentina, particularly following moves by Chile and Brazil to control JWH-018. Its legal status in Argentina remains ambiguous. [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote]

    [h="2"]Austria[/h]
    JWH-018 is illegal in Austria. [footnote=ref15]http://www.bmgfj.gv.at/cms/site/pres...S1229603682504[/footnote]

    [h="2"]Brazil[/h]
    As of 18th June 2010, JWH-018 is listed as a controlled psychotropic substance by ANVISA, the National Health Surveillance Agency of Brazil. [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote].

    [h="2"]Canada[/h]
    JWH-018 falls under item 1 of Schedule 2 of the Controlled Drugs and Substances Act which lists similar synthetic preparations of ∆-9-THC and other Cannabinoids [footnote=ref13]Canada. Department of Justice. Controlled Drugs and Substances Act. 20 May 2009. Department of Justice Canada. 10 June 2009 <http://laws.justice.gc.ca/en/ShowFullDoc/cs/C-38.8//20090609/en>.[/footnote].

    [h="2"]Channel Islands[/h]
    Sale of the smoking blend Spice has been banned from commercial shops in the Channel Islands [footnote=ref21]Heath, Richard. "Ban on Spice Sale." This is Jersey 7 Nov. 2008. Jersey Evening Post. 10 June 2009 <http://www.thisisjersey.com/2008/11/07/ban-on-spice-sale/>.[/footnote]. JWH-018 itself is not scheduled or controlled.

    [h="2"]Chile[/h]
    JWH-018 is illegal in Chile [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote].

    [h="2"]Finland[/h]
    JWH-018 is illegal in Finland as of 2012.

    [h="2"]France[/h]
    JWH-018 is illegal in France as of February 24th, 2009 [footnote=ref18]http://www.legifrance.gouv.fr/jopdf/...&pageFin=03495[/footnote].

    [h="2"]Germany[/h]
    JWH-018 is illegal in Germany as of January 22nd, 2009 [footnote=ref17]http://www.bgblportal.de/BGBL/bgbl1f/bgbl109s0049.pdf[/footnote].

    [h="2"]Luxembourg[/h]JWH-018 is illegal in Luxembourg [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote].

    [h="2"]Netherlands[/h]
    JWH-018 is illegal in the Netherlands [source needed].

    [h="2"]Poland[/h]
    JWH-018 is illegal in Poland as of May, 2009 [footnote=ref16]http://orka.sejm.gov.pl/Druki6ka.nsf/wgdruku/1547[/footnote].

    [h="2"]Romania[/h]
    JWH-018 is illegal in Romania [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote].

    [h="2"]Russia[/h]
    Smoking mixtures, including AM-HI-CO, Dream, Spice (Gold, Diamond), Zoom, Ex-ses, Pep Spice, Yucatan Fire and others are considered controlled substances, however JWH-018 and other synthetic Cannabinoid agonists have not been directly declared as scheduled or illegal[footnote=ref14]http://www.rospotrebnadzor.ru/press_center/press/2510/[/footnote].

    [h="2"]United Kingdom[/h]
    JWH-018 is a class B controlled substance in the UK under an amendment to the Misuse of Drugs Act 1971, effective 23rd December 2009. A number of other synthetic cannabinoids were also controlled as these laws came into effect. [footnote=ref20]http://www.drugs-forum.com/forum/showthread.php?t=87079[/footnote][footnote=ref37]http://press.homeoffice.gov.uk/press...an-legal-highs[/footnote]

    [h="2"]United States[/h]
    JWH-018 is currently unscheduled at the Federal level. It is not a structural or positional isomer of any scheduled compound, including ∆-9-THC and HU-210 (both Schedule I substances). It may however contravene the Federal Analog Act under certain circumstances due to the functional similarity to Schedule I substances. [footnote=ref19]Auwarter V, Dresen S, Weinmann W, Muller M, Putz M, Ferreiros N. “Spice” and other herbal blends: Harmless incense or cannabinoid designer drugs? Journal of Mass Spectrometry 2009.[/footnote][footnote=ref42]Analogs of JWH-018 illegal?[/footnote]

    On 24th November 2010 the Federal Drugs Enforcement Agency (DEA) published a notice of intent to use their emergency scheduling powers to add JWH-018, along with several other synthetic cannabinoids, to schedule I of the controlled substances list. This declaration triggers a minimum consultation period of 30 days. An official decision by the DEA is yet to be announced. [footnote=ref40]DEA Notice of Intent - Scheduling of synthetic cannabinoids[/footnote][footnote=ref41]DEA moves to emergency control synthetic marijuana[/footnote]

    Despite remaining unregulated at the federal level at this time, laws prohibiting the possession and sale of JWH-018 and other synthetic cannabinoids have been passed in several US states and municipalities. [footnote=ref38]US Legal Status of Synthetic Cannabinoids by State[/footnote][footnote=ref39]JWH-x bans, direct link to State Bills[/footnote]

    [​IMG]

    [h="1"]The history of JWH-018[/h]
    In progress

    [insights]jwh-018[/insights]


    [h="1"]More JWH-018 sections[/h]
    JWH-018 Info- Read & discuss information regarding JWH-018

    JWH-018 Experiences- Post & read experiences with JWH-018.

    JWH-018 File archive entries- Upload & read research & articles about JWH-018.

    JWH-018 Image gallery- Post & view pictures of JWH-018.
    [h="3"]The latest JWH-018 threads[/h]
    [showthreads=10]336[/showthreads]

    [CAT]Cannabinoids[/CAT] [CAT]Research Chemicals[/CAT] [CAT]Relaxants[/CAT]
    [CAT]Naphthoylindoles[/CAT]

    [h="1"]References[/h]
    [REFLIST][/REFLIST]
    [1] JWH-018 monograph
    [2] Calculated from Atomic Weights of the Elements, 2007
     
    Last edited by a moderator: Dec 2, 2010
  2. Bajeda

    Bajeda Platinum Member & Advisor

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    Regarding references:

    [6] Mouse99. JWH-018 Rat Pharmacokinetics. Raw data. Netherlands. 18 Dec. 2008.
    [7] Mouse99. JWH-018 Analysis. Raw data. Netherlands. 18 Dec. 2008.
    [8] Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.
    [9] Mouse99. JWH-018 Genotoxicity. Raw data. Netherlands. 18 Dec. 2008.
    [10] Mouse99. JWH-018 Cytotoxicity. Raw data. Netherlands. 18 Dec. 2008.
    [11] Mouse99. JWH-018 CYP450 Inhibition. Raw data. Netherlands. 18 Dec. 2008.
    [12] Mouse99. hERG: In vitro Test For The Potential of QT Interval Prolongation by JWH-018. Raw data. Netherlands. 18 Dec. 2008.


    Whats the 'Mouse99' bit at the start of each citation?
     
  3. Alfa

    Alfa Productive Insomniac Staff Member

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    That's the name of the member that uploaded the files to the archive. See the JWH-018 toxicology studies thread.
     
  4. runitsthepolice

    runitsthepolice Silver Member

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    The part about the legal status in the USA needs to be amended. In order for something to be considered an analog it has to be both a positional isomer and have similar pharmacological effects. If either condition is not satisfied it doesn't fall under the CSA. It is not a positional isomer so it's legal to possess in the USA. Also, it must be intended for human consumption, even if those two are satisfied.
     
  5. Phenoxide

    Phenoxide Super Moderator Staff Member

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    I've updated the information on legal status in the UK and Brazil based on what has been said in the forum. If anyone feels this information is incorrect please rectify it.
     
  6. Alfa

    Alfa Productive Insomniac Staff Member

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    Can someone update the legal status of JWH-018 in various countries and US states and include phenoxides legal map?
     
  7. Phenoxide

    Phenoxide Super Moderator Staff Member

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    The map has been added along with the recent developments in US federal law. I've also changed the legal status for Argentina as there seems to be some ambiguity there. The news article titled 'Argentina bans Spice' seemed to be more of a condemnation and warning rather than official legal change. Perhaps some spanish speaking members could throw some more light on this one?
     
  8. NeuroChi

    NeuroChi is not his mind Staff Member

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    Phenoxide, did you use a photo editing program and just a fill tool to generate this map?

    I'm wondering if we could someone use it as a standard for other such maps should other members be up for creating them. We would need a blank one I assume, the color's can be the same as the ones you've chosen.
     
  9. Phenoxide

    Phenoxide Super Moderator Staff Member

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    The map was made in Paint Shop Pro (Photoshop is too much for my small brain to handle). The base map was taken off the net and is not vectorized, so it doesn't color cleanly if the fill tool is used. I use a second layer to color the states in, outlining each with the brush tool then filling, which does not take very long to do. I also use additional layers for the state labels and Drugs-Forum watermark.

    If you want I can save the layers individually and send them to you. Then they can be stacked back together in your photo editing software of choice.
     
  10. John_bob

    John_bob Titanium Member Donating Member

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