I had acold a while back and took a cough suppressive dose of DXM (~30mg) as well as 5 g bali kratom, since I was feeling really sick. I got clobbered by the kratom, which would normally have been a modest dose. I did not have a fever. I know that drugs which occupy cytochrome enzymes in the liver can potentiate other drugs and wonders if this is what caused the kratom to seem so much stronger. Does anySWIM know if mitragynine and/or 7HOmitragynine are metabolized by or induce cytochromes, or is it perhaps that DXM is a narcotic and is synergistic with the narcotic effects of the kratom ? I am sensitive to the effects of DXM and feels that the highm with DXM, which made SWIM nod for about an hour, had some dextromethorphan overtones, though normally 30 mg would be unnoticed. DXM is metabolized by CyP450, but small amounts should not significantly occupy receptor sites. Has anyone ever taken kratom with recreational doses of DXM ? Is there any information on the metabolism of mitragynine compounds?