My close friend has had some very severe depression lately. I mean wicked and she has been taking Kratom to help feel better and it works, but there is kind of an up and down effect, which she doesn't like. I'm wondering if anyone else uses it for depression and any combinations that might be more effective. What doses work for depression? I know it's not good to use it every day, but she's felt so terrible lately she's got to find something that helps soon. Thanks.