In the past, I have recommended kratom as an aid for stimulant withdrawal, and has noted or recommended various mixes with other substances. He has felt for a long time that kratom is mostly benign, harmless and carries few risks (other than mild to moderate addiction with heavy use, and potentially strong nausea/vomiting with overdose). Lately I have had a drastic change of opinion, and (although he isn't saying anyone else should do this) threw out his entire supply last night and decided never to touch kratom again. He's certain he'll stick to this decision, now that he realizes the gradual, insidious, progressive and ultimately very nasty ways this substance has been undermining his mental and physical health. ISO, kratom is probably benign when used once or twice/week at most, in low to moderate doses, by itself, NEVER in association with other substances. Used more often, combined with other substances or e.g. to mask stimulant crashes, You is risking problems. They may take a while to show up, and can creep up so slowly that You may be oblivious for a long time, maybe never realizing kratom has been the culprit all along. Kratom seemed almost too good to be true to SWIM. Legal, natural/herbal, feels almost as good as Oxy or Hydrocodone, antidepressant qualities, seems to *cure* stimulant crashes, very mild withdrawals compared to opiates, no record of overdose deaths, many potential health benefits from alkaloids, etc. SWIM now believes he was right -- it is in fact too good to be true, and turns out to be false. I will go into more detail in further posts... it would be easier if asked specific questions, but if nobody does he'll try and sort his thoughts into a coherent storyline showing how he feels kratom has affected him over the past 2-3 years.