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liver repairing from acetaminophen

Discussion in 'Codeine' started by roidrage, Nov 2, 2007.

  1. roidrage

    roidrage Newbie

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    i hate doing the cwe since hard not to puke from taste and i dont want to waste any codiene, does anyone know after taking just 6 gram of acetaminophen once then next time in 3-4 days will liver be at 100% again to have another small dose?
     
  2. Tortoise

    Tortoise Newbie

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    Dude, no.
    How could a person have such disregard for their body that they'd risk damaging their liver just to get high once?

    Please don't take 6grams of acetaminophen.
     
  3. pillpopper96743

    pillpopper96743 Silver Member

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    To my knowledge, youd have to teake suppliments that the liver naturally produces, such as vitamin C,E etc. Id go to a health store and get liver suppliments and flush outs if I were you. The most SWIM had ever took in a session was 4.5 gram (9x 5/500 pills of vico), and had to wait 3 weeks for his liver to return to normal before continuing.
     
  4. Mint boi

    Mint boi Gold Member

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    if swiy hates the taste so bad then just mix the codeine solution with orange juice or something, tbh swiy shouldn't be dealing with more than 50ml of the stuff anyway so just knock it back like a shot and take it like a man!!
     
  5. Paracelsus

    Paracelsus Platinum Member & Advisor

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    Do you know anything about hepatic necrosis? This isn't about vitamins and "flush-outs" FFS!
     
  6. Ethyl

    Ethyl

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    the liver regenerates it self, but tends to become fibrotic and then necrotic when in extended periods (or high doses) of contact with substances/virus. This ultimates leeds to cirrosis and death.

    If you want to take something, here goes 2 things that might help:

    - Acetylcysteine - used in high doses to treat paracetamol poisining.

    - [SIZE=-1]silimarine, a plant extract that protects the liver against certain toxins, it is one of the antidotes for poisonouns amanitas.


    [/SIZE]
     
  7. Ethyl

    Ethyl

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    ALLWAYS DO A CWE!
    Take the result liquid from the cwe and make jellow. It won't hit as fast but not so slow, and little taste of the codeine. If concentrated you only need like 2 or 3 spoons..
     
  8. ncsponger

    ncsponger Silver Member

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    The less acet. you take the the more your body will like you. In swim's experience, it's very easy to cover up the taste of a codeine CWE. Just use plenty of your favorite soda or juice and down it. Don't destroy your liver, it's not worth any buzz.
     
  9. pillpopper96743

    pillpopper96743 Silver Member

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    No I really dont know that much about hepatic necrosis, and I never said I did. Im just giving some advice based on SWIMS experience and what he looked up online about the care for your liver. The vitamins and flush-outs helped SWIM, so im telling the thread starter about it. It isnt a knowledge competition dude, so just chill out.:cool: (If your liver is damaged from acetaminophen, suppliments and toxicity flush-outs will help it to repair itself for another session of codeine popping in 3-4 days, even if it is small. Trust me on this one. SWIM has done this before.)
     
  10. Paracelsus

    Paracelsus Platinum Member & Advisor

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    Dead (necrotic) cells don't magically regenerate in 3-4 days, even when aided with vitamins and dubious toxin flush products. Don't offer advice if you don't know what you're talking about. Single anecdotal case reports (e.g. "I did this and nothing happened so it's totally safe") are worthless in thsi case.
     
  11. chico

    chico Iridium Member

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    I think the max daily dose is 4000mg or vicodin 5/500. Anything above that is playing with fire!
     
  12. Pondlife

    Pondlife Platinum Member & Advisor

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    This subject comes up again and again, and it's potentially much more serious than many people think.

    Acetaminophen (aka Paracetamol) toxicity is often poorly understood. There are three key things to remember:

    1. At the recommended doses acetaminophen is perfectly safe; but an overdose is very harmful and can be fatal.
    There is not a linear dose/toxicity curve, with small amounts causing minor toxicity and larger amounts causing gradually increasing damage. Small amounts cause absolutely no toxicity, but past a certain point serious liver damage starts to occur.

    2. The difference between the maximum recommended dose and a potentially toxic dose is much lower than many people think.
    The toxic dose is typically between 4g and 6g depending on the person. That means that taking just eight 500mg tablets could be toxic - that's only four times the recommended dose.

    3. A toxic dose produces no noticeable effects until after the damage has occurred.
    Symptoms don't appear until between 16 and 36 hours of the overdose, and by then the damage is done. The damage is not reversible, and in severe cases a liver transplant is required to avoid death by liver failure.

    The mechanism behind the toxicity is as follows:

    Acetaminophen is metabolised by two pathways: about 90% is metabolised through glucuronidation, which yields a non-toxic metabolite, and the remaining 10% is metabolised by CYP, which yeilds N-acetyl-p-benzo-quinone imine (NAPQI). NAPQI is very toxic to the liver, but it is inactivated almost immediately by glutathione before it does any damage.

    The problem occurs when the liver's store of glutathione is exhausted. Then the NAPQI starts to kill liver cells, resulting in liver damage.

    The ratio between the two metabolic pathways differs between individuals, as does the amount of glutathione stored in the liver. These two factors account for the range of toxic doses between different people.

    You can think of the maximum safe dosage using the leaky bucket analogy. Imagine a bucket with holes in the bottom. The capacity of the bucket represents the liver's store of glutathione, and the flow rate through the holes represents the regeneration rate of glutathione. A single dose of acetaminophen will not cause any problems if it is less than the bucket's capacity. Also, a person can continue to take acetaminophen providing the rate of consumption is less than the rate of glutathione regeneration. If either of these is exceeded, then the bucket overflows and liver damage will result.

    To answer the OP's question: No, 6g of acetaminophen is not safe. It's around the level where liver damage starts to occur for most people, and you'd be mad to risk that just to avoid a bitter taste.
     
  13. darkglobe

    darkglobe Silver Member

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    Just to clarify: When you say liver damage, do you mean irrevocable liver damage? Or would SWIDoofusOriginalPosterGuy probably have got away with it this time?
     
  14. Paracelsus

    Paracelsus Platinum Member & Advisor

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    All tissues can regenerate, except neurons. But with serious liver necrosis one may die before there is any chance for regeneration.
     
  15. oxyaddict420

    oxyaddict420 Newbie

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    I hate for this to be my first post but I am scared now by reading these comments.. I currnetly took 35 5/500 vico over a 22 hour period.. each dose was 7 5/500.. First dose was at 6:00pm last night, then 1:00am, then 3:00am: then 5:00am then I started to worry about the tylenol and waited about 11:00 hours until i took the last dose at 4:00pm this afternoon.. There has been times where I have taken around 20,000mg of tylenol 3 or 4 days in a row.. I had NO IDEA about this CWE method.. I just found it due to searching the internet on tylenol overdose info.. I weigh 300lbs and I will not take any more AT ALL! But will I be ok? I am scared from what i read above.. Is it too late to flush my system? If not what do I use and where do I get it? PLEASE HELP!
     
  16. Tortoise

    Tortoise Newbie

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    Oxyaddict, sorry to say it but Swiy is right to be concerned. Swiy should get his arse to a hospital and be totally honest with them about what he's done. He will probably be given activated charcoal among other things. Don't wait until it's too late, tell him to go now! There is no other sensible option.

    ps. read the forum rules re: self incrimination some time.
     
  17. Mint boi

    Mint boi Gold Member

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    as tortoise said hospital is the place you want to be right now, better safe than sorry. An overdose of this sort doesn't usually begin to show any signs until alot of damage has been done so don't leave it till you begin to feel crappy.
     
  18. oxyaddict420

    oxyaddict420 Newbie

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    Thank you for the quick reply.. Swim is SCARED to go to the hospital in fear of what they will do to him.. Is there any other option? Lets say Swim decides not to go no matter what.. What are Swims best chances at this being ok? Altogather it has been 17,500mg over a 26 hour period counting now.. Swim read in a rx type website that it would take like 30 extra strength tylenol 500mg in an 8 hour period to have a overdose, and if untreated 3 or 4% were affected negatively!!! Is there ANY alternatives? PLEASE? FOR Swim?
     
  19. Mint boi

    Mint boi Gold Member

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    to be honest there's not alot swiy can do for himself at this late stage, most of the substance will have been absorbed, so activated charcoal would be a waste of time almost. The people at the hospital won't do anything to you except help! Although you might have to talk to a shrink after. TBH if swiy is totally agaisnt going to the hospital theres not alot swiy can do except stay calm, and hope no damage has been done.

    (Im not trying to scare swiy, hopefully nothing will come of this other than a lesson learned, but again better safe than sorry, and that was a large dose swiy took)
     
    Last edited: Jan 18, 2008
  20. Paracelsus

    Paracelsus Platinum Member & Advisor

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    Make your choice. The hospital will do nothing but keep you under observation, draw blood from time to time (to do various tests), and fuel you with the standard antidote. Don't worry about them reporting you to the authorities.