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Health - Long Term Effects of Diphenhydramine?

Discussion in 'Deliriant antihistamines' started by xyccoc, May 15, 2007.

  1. xyccoc

    xyccoc Newbie

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    SWIM has, every day for the past two years, been taking between 375mg and 625mg of diphenhydramine before bed (usually 2-3 hours before.) He or she started using it because of insomnia, but got into chronic use after falling in love with its mellowing recreational effects. In the long term, SWIM has not encountered any noticeable health problems, but is curious if there are any he or she would be aware of? SWIM knows it isn't a good idea, for obvious reasons, but he or she so far has no reason to stop.
     
  2. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Re: Long term Diphen usage

    625 mg?Whoa thats alot of diphenhydramine.SWIM used to be a very frequent user for both sedative and recreational purposes and has a very big tolerance to it but still wouldn't ever consider something as high as 625 mg.Mellowing recreational effects?More like delerium,hallucinations,and temporary psychosis.SWIM is not sure of the exact health risks involved but still does not think that much is such a good plan.
     
  3. xyccoc

    xyccoc Newbie

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    Re: Long term Diphen usage

    Well SWIM's usual dose is 18 pills, or 450mg, but once in a great while may feel like doing 25ish pills. SWIM has definitely built up a tolerance to it, hence the higher dose. SWIM enjoys the heavy feeling, and how the drug makes most things more interesting. The severe loss of short term memory, oddly enough, is also found to be enjoyable. The deleriant effects like the hallucinations, both visual and auditory, along with the incredible dreams, are always found to be an excellent end to the day.. plus (unless he or she takes too much), sexual arousal and orgasm is greatly enhanced. He or she has also found that too much of the diphen makes it impossible for him or her to fall asleep, which isn't fun at all, expecially on hot nights. Besides from the acute effects, it doesn't seem to have done any permanent damage to SWIM's senses or body in any way. Something may sneak on on SWIM in the future, though, which he or she would like to be aware of.
     
  4. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Re: Long term Diphen usage

    Before SWIM developed an opiate habit he liked those effects of diphenhydramine aswell but afterwards it simply made him uncomfortable and feel a greater need for opiates.A few months ago when SWIM was going through some VERY BAD opiate withdrawals he made the mistake of eating about 20 benadryls.Life literally became a nightmare and SWIM felt strange pain in his arms and bodies.Now SWIM only uses diphenhydramine to go to sleep which is really little help because he has such a tolerance to it.
     
  5. xyccoc

    xyccoc Newbie

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    Re: Long term Diphen usage

    Well SWIM has been using for over 2 years nightly and really has had no reason not to continue. Effects everyone differently SWIM supposes.
     
  6. Nacumen

    Nacumen Newbie

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    Re: Long term Diphen usage

    With frequent doses like that, I'd be surprised if you could still see straight. The HPPD that SWIM gets from such large doses of diphenhydramine makes the ground flow like waves for days afterward, not to mention the dementia that lasts well into the next day.
     
  7. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Re: Long term Diphen usage

    SWIM simply can't understand how someone can have such a huge tolerance to it.SWIM thought he had a tolerance and it seems like with diphenhydramine a tolerance develops almost over night.SWIM guesses it could be good that you like it because it is cheap,it is legal,and can be gotten almost anywhere.Still SWIM just couldn't see just using diphenhydramine and nothing else.That would get rather boring.
     
  8. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Longterm diphenhydramine effects on the mind?

    Swim is wondering if anyone has any fact based info on the longterm effects of heavy diphenhydramine use on the human psyche?Swim has googled this and not really been able to find anything.This is of great concern to swim because swim has never been "all there"but it seems like after years of diphenhydramine abuse starting in 98 it's gotten far worse.Swim doesn't abuse it now but is worried that some of the damage may be irreversible.Swim is far more paranoid than he once was,more fit to moodswings,ofcourse an opiate dependency could be part of the problem aswell.
     
  9. beentheredonethatagain

    beentheredonethatagain Silver Member

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    Re: Longterm diphenhydramine effects on the mind?

    The taking of medicine to offset the negative affects of drug abuse is just piling on more potential negative problems. I would suggest to myself if I were battling the opiates a detoxing period, just to clean out the old pipes.

    Welcome back and the best of blessings !!!
     
  10. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Re: Longterm diphenhydramine effects on the mind?

    Well opiate addiction does have its problems true,however swim was abusing diphenhydramine before opiates and fears that this actually in someways has had a more negative effect on swim.Unfortunately swim can not find any real information on the effects of heavy diphenhydramine use.Its hard to find anyone with this knowledge.
     
  11. Orchid_Suspiria

    Orchid_Suspiria Newbie

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    Diphenhydramine leads to dementia?

    A doctor told swim longterm use of diphenhydramine can lead to dementia.Swim has been searching google for evidence of this and all he can find is ofcourse articles on shortterm diphenhydramine delerium being bad for people with dementia but can find no cases of diphenhydramine being the cause for dementia.Could this doctor have been lying?Does anyone have any information that this is true?
     
  12. sarbanes

    sarbanes

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    Re: Diphenhydramine leads to dementia?

    I wouldn't worry about it - the worry will hurt you more than the benadryl. If youo are using so much diphen that you are constantly hung over, then perhaps, maybe maybe you might worry a slight bit, short term. AFAIK, there is no evicence this compound (or its metabolites) pose any sig neural toxcicity.
     
  13. Paracelsus

    Paracelsus Platinum Member & Advisor

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    Re: Diphenhydramine leads to dementia?

    Diphenhydramine, like all anticholinergics, causes cognitive impairment. While there is no evidence that long-term use causes lasting impairment, use of diphenhydramine in borderline demented elderly people (who often have a slow metabolism) can exacerbate their condition. There is close to no data available on long-term recreational use, maybe because few people find it enjoyable.
     
  14. GForce

    GForce Gold Member

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    The Combined Long Term Effects of Diphenhydramine? Thread

    I know there are a few threads on this issue, but they didn't really have the answers I was looking for. SWIM uses diphenhydramine a few times a week to help get a good night sleep. I was wondering what organs are involved in the metabolism of diphenhydramine and if long-term use can be dangerous to those organs. I saw the other thread had mentioned how it effects the mind in the long-term, and there wasn't much of an answer, so if anyone knows anything I'd want to know that as well. However, I think because SWIM takes 100mg when he needs to sleep and doesn't use the medicine recreationally that it can have long-term effects on his brain, but you never know.
     
  15. Jatelka

    Jatelka Psychedelic Shepherdess Platinum Member & Advisor

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    Re: Long-term Diphenhydramine Use

    Diphenydramine is metabolised by the liver. CYP2D6 has the greatest activity. CYP1A2, CYP2C9, and CYP2C19 are also involved, but to a much lesser extent.
     
  16. El Calico Loco

    El Calico Loco Newbie

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    Re: Long-term Diphenhydramine Use

    It's difficult to find any information on long-term side effects. As Orchid said, DPH is not that popular. Scientific and medical sites assume that one is using it according to the instructions on the label. It's even tough to find information on long-term side effects of medical doses. No one seems to know the LD50 in humans, just that it's 500mg/kg in rats. An article on schoolnurse.com claims that the human "lethal dose" is 2.8g, but the article doesn't say whether this is LD10 or LD50 or what...and I don't know how reliable that site is anyway, having never heard of it before.

    Swim is particularly interested in this because he often - nearly every day - takes several 50mg doses for his horrid allergies. We may not know for sure, but we might be able to make an educated guess based on how our bodies work and what DPH does to them.

    It plugs histamine receptors, which I think would leave more histamine floating around in the bloodstream. Over time, chronic use might lead one's body to release extra histamine in an attempt to get back to baseline. I'm not sure what high histamine can do to a person aside from anaphylactic shock and high adrenalin levels, which I doubt would happen. I'd be willing to bet it would cause something autoimmune, however - allergies, at least.

    DPH inhibits the uptake of serotonin - like modern antidepressants (Prozac was derived from it), but not as dramatic. Chronic DPH use might have affects similar to (but probably less powerful than) chronic SSRI use.


    ECL
     
  17. snapper

    snapper Gold Member

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    Re: Long-term Diphenhydramine Use

    Well, the track record of human use is there and it has so far proven to be benign at therapeutic doses. Histamine release is mediated by allergens and other stimulators of mast cells and eosinophils (white blood cells) so levels should not rise with blockage of receptors.Given that diphenhydramine is metabolized by cytochromes, benadryl could possibly increase the number of cytochrome enzymes in the liver, as well as prevent other drugs metabolized by cytochromes from being metabolized as fast, but overall there are probably little long term consequence to long term use at normal doses. Recreational doses probably do some damage, since anticholingeric effects predominate at these levels (ie-similar to datura, brugmansia, etc).
     
  18. Graduisic

    Graduisic Palladium Member

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    Chronic use of diphenhydramine - effects

    swim has been told by his doctor that this works best for sleep problems. swim finds himself taking it nearly every night because without it the sleep experience becomes very poor.

    swim has gotten into a bad habit, he thinks. 50-100mg diphenhydramine per night im sure is going to cause problems down the road.

    at this level of use, how serious are the risks to this? i've read that not only can it dry one's sinuses, but also after awhile can dry up stomach lining as well?? other things swim has heard is that it is very taxing on the liver.

    Thanks!

    this is not abuse for recreational purposes, this is for use as a sleep aid. 50-100mg is 1-2 pills
     
  19. thenightwatch

    thenightwatch Silver Member

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    Re: Chronic use of diphenhydramine - effects

    SWIM was in a similar habit around a year ago. He does not remember any serious side-effects. During the days after taking diphenhydramine, he experienced mainly mild brainfog, and a moodlift that felt like it could have been explained by slightly increased 5HT levels.

    Also of note, despite nightly use for a period of a couple months, his nightly dose of 50-100mg was completely adequate for sleep every night, with little signs of tolerance developing.

    SWIM would agree that the habit is probably not too healthy to be in, but just wanted to offer some assurance that its nothing TOO horrible. SWIM would say try to kick the habit, and definetely don't up the dose!

    Also also of note, SWIM was not concurrently using any drugs at this point other than cannabis. If you are using any other types of chemicals and then taking diphenhydramine at night, chances for long term side effects are likely greatly increased!
     
  20. Graduisic

    Graduisic Palladium Member

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    Re: Chronic use of diphenhydramine - effects

    thanks for the quick reply. good to hear there are no dangerous side effects; swim has not noticed any. swim's brother is not allowed to take diphenhydramine because of its negative effects on the prostate, so i'm guessing that if someone makes it a month taking this as a sleep aid, they're pretty much in the clear from side effects

    swim doesn't mix dph with anything but cannabis and nicotine. alcohol in particular is extremely taxing on the liver when combined with diphenhydramine. besides, swim finds that taking diphenhydramine and trying recreational drugs within 18 hours of each other, diphenhydramine seems to put a damper on fun effects anyway, regardless of any bodily damage (which has the potential to be severe).

    sounds like if swim maintains being as careful as he is, he should be fine :)