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Dose - Lorazepam and alcohol.

Discussion in 'Benzodiazepines' started by hmmhmm, Jul 19, 2008.

  1. hmmhmm

    hmmhmm

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    Swim tried 2 mg of Lorazepam by itself and It didnt do much for him. Tonight Swim wants to try it with alcohol. Swim wants just a good night of partying where he is "free" but SWIM is not a big drinker at all. Swim wants to know 2 mg + 1 beer would be good enough?
     
  2. Pino

    Pino Gold Member

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    Although it isn't the safest thing combining alcohol and lorazepam, swim mixed 2mg with 2 beers many times. Swim thinks one beer wouldn't hurt.

    Swim finds a good thing to potentiate lorazepam is keep them in the mouth until they melted away. The effect kicks in faster that way.
     
  3. Politicalchalk

    Politicalchalk Titanium Member

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    A single, clinical dose of lorazepam (2mg, for ex) only occupies about 3 percent of your total benzo receptor capacity. This may be why it's so difficult to OD on benzos alone. Also, lorazepam has less action of respiration areas relative to other benzos. Just be careful, as the more of each in your body, the more inhibitions are lowered, and thus, the more you think you can handle.

    Also, Swim is tired of hearing this poppycock about sublingual (under the tounge) administration of lorazepam. It's true, there are dosage forms of lorazepam available for sublingual administration -- but the average script one gets is intended for ORAL administration. Presumably, melting it under the tounge simply leads to a swallowing of chalky-tasting mess in your mouth, and a placebo-induced onset of action. Unless the tablet is designed specifically to be absorbed in the blood vessel under one's tounge....

    Sorry, but until swim sees real data on the issue, he just does not believe sublingual admin. is gonna happen with a regular tablet. This is akin to someone snorting drug A, but whose effects are apparent only after the "drip."

    In the interests of transparency, Swim has been stabilized on 6mg lorazepam/day for months.
     
  4. Pino

    Pino Gold Member

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    Swim wasn't sure it really worked. It probably is placebo, because he looked up and lorazepam isn't soluble in water. He thought it would work, because it works great with zolpidem.

    It is a bit pity the placebo effects is ruined though ;)
     
  5. bol

    bol Newbie

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    SWIM has tried lorazepam and alcohol three times.

    First time: 2mg and five beers. No blackouts. Very nice evening.
    2nd time: 1mg, MJ and 7-8 beers. No blackouts. Even better evening.
    3rd time: 1mg, 4 beers. No blackouts. I was tired, but it was ok.
     
  6. Jatelka

    Jatelka Psychedelic Shepherdess

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    As stated, many times before, mixing drugs with additive depressant actions cannot be recommended.

    There is a real risk of oversedation, amnesia (and inadvertant necking of more benzos than intended) and other, more troublesome adverse effects, such as reduced consciousness level (inability to protect own airway and risk of choking on one's own vomit), as well as respiratory depression.

    Benzodiazepines alone are remarkably safe in overdose: Mix with alcohol and you are asking for trouble
     
  7. bol

    bol Newbie

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    But if SWIY is going to take benzos and alcohol together. ( not recommended ). First take the benzos, then wait over an hour and then start drinking alcohol. And SWIY must know SWIYs limits and SWIY shouldn't be too greedy when mixing these two psychoactive substances.
     
  8. SomniphileXII

    SomniphileXII Silver Member

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    My cat has been taking benzodiazepines medicinally to treat panic disorder/agoraphobia/avoidant personality disorder kind of deal for a number of years now. She does not typically drink alcohol; but, she's used morphine in the form of opiums and/or pharmaceuticals for a number of years as well.
    From her experience, the best way to potentiate benzodiazepines (in specific, lorazepam because it contains all of the benzodiazepine effects, which makes it her favorite) is to take 2-6mg, depending on the situation (I will further add that this is JUST her medicinal dose and everyone has their own dose due to tolerance etc.), and place the SL tablets under the tongue. She then will proceed to place an alcohol underneath the tongue to quicken the dissolve and therefor absorption because benzodiazepines are typically freely soluble in alcohol, more soluble than in saliva.
    She would then consume one 7% beer or its equivalence to aid the CNS depressant effect.
    She always takes 100-200mg dimenhydrinate or 50-100mg diphenhydramine (diphenhydramine in its own is 2-fold more potent because dimenhydrinate has to be broken down into diphenhydramine in the liver, but I digress) whilst taking benzodiazepines.
    This is her medicinal ritual for high anxiety/panic situations.

    Recreational would, typically, be a higher dosage of benzodiazepine with a similar dosage of potentiators. 6-10mg works fine for her personal situation.
    When adding opiates to the brew, one would be wise to reduce all doses and maybe even dose respond. 30-60mg codeine seems to work fine with around 150mg dimenhydrinate, 6mg lorazepam kind of doses for her.
    The addition of grapefruit never hurts as it inhibits CYP3A4 which is responsible for the breaking down of many benzodiazepines, as well as dextromethorphan, opiates, psilocybin, and some other drugs.

    I hope this has shed some light on the idea of benzodiazepine potentiation. Ativan is used intrabuccally because saliva is not only water therefor the water solubility of Ativan does not matter here, especially since one is probably swallowing the remaining chemicals left in the saliva after the hour or so that they might let it absorb for.

    Have an excellent evening, be safe when medicating, thank you.

    I further add in retrospect that it is of course not recommended to mix CNS depressants and such actions should not be taken unless one is sure of their bodily reaction and even then it is dangerous business to step into. Safety before any thing else.
     
    Last edited: Feb 27, 2012