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Pharmacology - Loxapine : More of an atypical or typical antipsychotic ?

Discussion in 'Antipsychotics' started by OrbitalSPIN, Jan 1, 2010.

  1. OrbitalSPIN

    OrbitalSPIN Newbie

    Reputation Points:
    Aug 16, 2009
    Male from U.S.A.
    As a hobbie and for pesonal reasons SWIM researches Pharmaceuticals. One in particular has caught SWIMs attention. It is an antipsychotic called Loxapine, Its a member of the Dibenzoxazepine class, its chemical structure is 2-chloro-11-(4-methylpiperazin-1-yl)dibenzo[b,f] [1,4]oxazepine. Its structurally related to Clozapine and it has antidepressant effects. When Loxapine is metabolized in the body some of it is metabolized by N-demethylation to Amoxapine, a tricyclic antidepressant. Its been argued amoung many Pharmaceutical researchers and some Doctors that Loxapine behaves more like an atypical antipsychotic than a typical antipsychotic. SWIM agrees with this notion of Loxapine being an atypical and thinks that this medication should be given a second look to treat some Psychiatric problems. Question#1: Although Loxapine is classified as a typical antipsychotic does a FOAF think its more of an atypical antipsychotic ? Question#2: Does a FOAF think that this medication should be given a second look amoung Pharmaceutical researchers and Doctors ?
  2. chibi curmudgeon

    chibi curmudgeon Gold Finger Gold Member

    Reputation Points:
    Nov 26, 2008
    Female from U.S.A.
    Loxapine kind of sucks. Based on the side effect profile, I'd consider it a typical AP, though iirc it's closer to clozapine than, say, haloperidol. It's possible I'm confusing it with something else, though.

    My humble opinion is that clozapine isn't that bad, as long as one doesn't have a problem with weight gain or white blood cells, and I wouldn't consider it last-line therapy. But loxapine has all of the dyskinetic, NMS, hyperprolactin type crap going on, and I'd place it in the last resort category.

    I don't think I've ever seen it prescribed, and in class it wasn't even brought up. Typical or not, it's one of the crappier APs.