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Drug info - MDAI (5,6-methylenedioxy-2-aminoindane) Drug Info

Discussion in 'Research Chemicals' started by LowCrawl To Freedom, Aug 14, 2009.

  1. LowCrawl To Freedom

    LowCrawl To Freedom Newbie

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    MDAI( 5,6-Methylenedioxy-2-aminoindane) has just became available on a popular RC site, and SWIM is interested. There isn't much on-line info about it besides a small Wiki article. Any swimmers had any experience with it? Is it worth SWIMS time and money? Also SWIM was thinking about mixing it with methylone...
     
  2. thv20

    thv20 Silver Member

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    Re: Mdai

    The lack of dopamine release might make this compound less interesting than it sounds. Then again, no neurotoxicity is a big plus.

    Mixing with Methylone could be very sedate, lots of nice warm glow? Might also end up being a very expensive nap :laugh:
     
  3. LowCrawl To Freedom

    LowCrawl To Freedom Newbie

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    Re: Mdai

    I guess there is only one way to find out....hehe :p... Also SWIM thinks mixing it with methylone would make it more stimulating.. Seeing how M1 makes SWIM feel sped up a bit.
     
  4. Terrapinzflyer

    Terrapinzflyer MDMA, RC & News Forums Platinum Member & Advisor

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    MDAI 5,6-Methylenedioxy-2-aminoindane

    Please post info about 5,6-Methylenedioxy-2-aminoindane (MDAI) here.
    Can anyone add information about:
    • names / synonyms
    • molecule
    • dose
    • duration
    • side effects
    • legal status
    • have there been any reported incidents with this compound?
    • since when has this research chemical been available?
    • stability of the molecule / compound

    Names:
    IUPAC: 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine

    Experiences with MDAI should be discussed here: MDAI Experiences page

    [​IMG]

    Research Chemicals Index - Phenethylamines
    Research Chemicals Index - Tryptamines
    ________________________________________________________________________________________________________________

    Another one from the David Nichols team at Perdue, apparently from sometime in the 90's.

    Apparently derived in some sense from MDA? Reportedly non-neurotoxic, empathogenic, and is an SSRA (selective Seratonin Releasing Agent)
     
    Last edited by a moderator: Jun 30, 2010
  5. runitsthepolice

    runitsthepolice Silver Member

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    Re: MDAI 5,6-Methylenedioxy-2-aminoindane

    5,6-Methylenedioxy-2-aminoindane (MDAI) was developed at Purdue University by David Nichols. It's a highly selective serotonin releasing agent. It can produce empathogenic effects but without any stimulant action.

    Looks not that exciting.
     
  6. Terrapinzflyer

    Terrapinzflyer MDMA, RC & News Forums Platinum Member & Advisor

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    Re: MDAI 5,6-Methylenedioxy-2-aminoindane

    different strokes for different folks turtle supposes.

    Empathogenic, non-neurotoxic and non-stimulant sounds like a substance worth exploration to turtle...
     
  7. yaniczka

    yaniczka Silver Member

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    Re: Mdai

    if there is not enough dopamine, maybe mephedrone could be better to mix with than methylone? meph feels much speedier than m1 to swim. very interested in the substance as well, but a bit afraid that if it was any good, it would be already popular. well lets hope it is a forgotten gem and the price will be reasonable too :thumbsup:
     
  8. Bluenun

    Bluenun Newbie

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    Re: Mdai

    SWIM has taken this a few times in the past couple of months.
    He started of with a low dose of 80mg and could hardly even notice any effects.

    Even 150-200mg was a very mild experience.
    SWIM found a dose of 250-300mg to be a worthwhile experience.
    Swallowed it took a long time to feel anything, 90 minutes but plugged was about 60 minutes.

    By far the best experience was 300mg of MDAI plugged and 250mg of Mephedrone 2 hours later.

    By the way it is a tan powder.
     
  9. LowCrawl To Freedom

    LowCrawl To Freedom Newbie

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    Re: Mdai

    ^Hmm i guess SWIM will start with like 250mg. He thinks that sounds reasonable:) Mabye throw in a 250mg bomb of M1 in there a couple hours into it.
     
  10. runitsthepolice

    runitsthepolice Silver Member

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    Re: Mdai

    By the way, mdai (serotonin releaser)+ssri (serotonin reuptake inhibitor)=serotonin syndrome, which is bad.

    Don't take MDAI with an SSRI. This is an educated guess. I don't have any references to support this.

    Correct me if I'm wrong.
     
  11. bazbonehead

    bazbonehead Newbie

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    Re: Mdai

    what, such as 5-HTP? Ive never tried this but ive heard it increases your serotonin levels back to baseline if they have been low, but ive also heard of this SSRI, which sounds a tad scary. Swim and his mates were discussing whether combining 5-HTP with methylone would create a sort of "self-sustaining" high with the methylone using up serotonin and 5-HTP replenishing it, but if this is dangerous, swim would rather hear a few positive reports before swim tested it out. On a further note, this SSRI, is it only likely to happen if you mix the two, or also if you take them on seperate occasions, or even with one not the other?

    thanx

    bazbonehead added 2 Minutes and 6 Seconds later...

    sorry when i refer to SSRI, i mean to say serotonin syndrome. cannabis is confusing!
     
    Last edited: Aug 26, 2009
  12. EscapeDummy

    EscapeDummy Palladium Member

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    Re: Mdai


    I think he's more referring to things along the lines of Prozac or Zoloft, something along those lines. SSRI's are selective serotonin reuptake inhibitors. So imagine a sink, the amount of water in the sink is your level of serotonin - the more water, the 'higher' you are. Taking MDAI would be like turning up the sink a lot. Now the water level is rising somewhat, and it meets the amount of water being drained halfway up the sink. Taking an SSRI doesn't increase serotonin, it just inhibits it from being metabolized. So this SSRI basically is like clogging up the sink a lot. Serotonin Syndrome, in this analogy, is when the sink overflows, because the drain is clogged AND a lot of water is comin out. Hope this helps somewhat.


    Anyway, lots of people who do MDMA take 5HTP prior to or after their roll to feel better the next day. Swim hasn't done E before but of his friends who do this, some report it helps them somewhat, others report that it's all placebo.
     
  13. Tacitus

    Tacitus Newbie

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    Re: Mdai

    Has SWIY tried insufflating this substance? Is it painful?

    Would it be dangerous to mix with Mephedrone (now known to be an MAOI)? If so, how long should be waited between the MDAI dosification and the Mephedrone dosification?

    SWIM will be receiving 1gr of the substance in some weeks, any information you could give about the previous questions will be appreciated.



    Thanks & regards.
     
  14. nibble

    nibble Titanium Member

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    Re: Mdai

    Since when has it been established that mephedrone (4-methymethcathinone) is an MAOI?
     
  15. LowCrawl To Freedom

    LowCrawl To Freedom Newbie

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    Re: Mdai

    So... Do any swimmers think that a starting dose of 250mg would be a bad idea?
     
  16. fnord

    fnord Newbie

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    Re: Mdai

    Yes this substance is new and has had very little human testing,so start low and work your way up,you can always take more of a drug once youve established how its going to affect you,you can never untake a drug.
     
  17. LowCrawl To Freedom

    LowCrawl To Freedom Newbie

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    Re: Mdai

    ^yea you are right. Was kinda a stupid question for SWIM to ask. SWIM inst new to the RC game, and knows to always start small. He is just a lil antsy and looking to get the most bang out of his buck..
     
  18. cyferman

    cyferman Newbie

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    Re: Mdai

    i would suggest if this chem is pricy you dont wanna waste any, or any of your time doing it. If you take a low dose you may never be able to reach a desired level of effects by re-dosing if u dont feel anything. I would follow the advice above, happy swimming :thumbsup:
     
  19. enquirewithin

    enquirewithin Newbie

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    Re: Mdai

    Dr David Nichols has done work with rats on this.

    http://anonym.to/?http://www.ncbi.nlm.nih.gov/pubmed/1967651
     
    Last edited by a moderator: Nov 23, 2010
  20. Terrapinzflyer

    Terrapinzflyer MDMA, RC & News Forums Platinum Member & Advisor

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    Re: Mdai

    does anyone know what the difference would be between the HCL salt and the base version of this substance?