MDMA to treat Parkinson’s!

Discussion in 'Ecstasy & MDMA' started by radiometer, Aug 3, 2005.

  1. radiometer

    radiometer bananadine addict Platinum Member & Advisor

    Reputation Points:
    Apr 13, 2005
    from U.S.A.
    Haha! Put that in your pipe and smoke it, Ricaurte!!

    Amphetamine-related drugs ameliorate symptoms of Parkinson's

    To model Parkinson's disease, researchers bred mice with severe
    dopamine deficiencies that displayed rigidity, inhibited motion, and, as
    seen here, freezing behavior. (Photo: Caron et al.)

    The debilitating effects of Parkinson's disease are well known: muscle
    rigidity, impaired movement, and the uncontrollable shaking that makes
    even the most mundane activity a challenge. The symptoms result from a
    progressive deterioration of neurons, found in the midbrain, that produce
    dopamine. With no cure on the horizon, the most common treatment
    involves administration of the dopamine precursor, L-DOPA, usually in
    pill form. Though symptoms subside at first, this treatment is rendered
    ineffective over time.

    In a new study reported in the open-access journal PLoS Biology, Tatyana
    Sotnikova and colleagues from Duke University create a mouse model
    that recapitulates many of the symptoms of Parkinson's disease and use it
    to screen potential therapeutic drugs. By eliminating the dopamine
    transporter - the protein responsible for recycling the chemical into
    neurons - in mice, the authors reduced dopamine levels in the midbrain
    by 20-fold. In addition, chemically inhibiting dopamine production in
    these mice resulted in essentially unmeasurable levels of the
    neurotransmitter, since it could now neither be produced at normal levels
    nor be recycled.

    The authors tested a number of drugs at various doses and found that in
    addition to L-DOPA-related treatments, drugs related to amphetamine
    were effective in ameliorating muscle rigidity, tremor, and impaired
    movement in these mice. Most effective was
    methylenedioxymethamphetamine HCl (MDMA), commonly known as
    ecstasy. It has been shown that amphetamines can trigger release of
    neurotransmitters such as dopamine, serotonin, and norepinephrine and
    cause sudden bursts in neurotransmission, leading to a feeling of
    alertness, increased muscular activity, and reduced fatigue. This study,
    however, shows that treating mice with MDMA does not increase
    dopamine levels; furthermore, treating the mice with drugs related to
    serotonin or norepinephrine did not ameliorate the disease's symptoms.
    These results suggest that MDMA likely acts through a pathway unrelated
    to these common neurotransmitters.

    Future work will be required to understand how MDMA was able to
    ameliorate the symptoms of Parkinson's in these mice and to assess the
    toxicity of MDMA and related compounds in greater detail in the future.
    However, this study opens the door to a search for compounds related to
    ecstasy, which may provide a more effective treatment in the later stages
    of the disease - and hopefully allow patients to perform the simple
    functions of everyday life independently again.

    Citation: Sotnikova TD, Beaulieu JM, Barak LS, Wetsel WC, Caron MG, et
    al. (2005) Dopamine-independent locomotor actions of amphetamines in
    a novel acute mouse model of Parkinson's disease. PLoS Biol 3(8): e271.

    Marc G. G. Caron
    Duke University Medical Center
    Rm 487 CARL Bldg, Research Dr.
    Durham, NC USA 27710


    All works published in PLoS Biology are open access. Everything is
    immediately available without cost to anyone, anywhere--to read,
    download, redistribute, include in databases, and otherwise use--subject
    only to the condition that the original authorship and source are properly
    attributed. Copyright is retained by the authors. The Public Library of
    Science uses the Creative Commons Attribution License.
    Last edited by a moderator: Oct 27, 2010
  2. Nagognog2

    Nagognog2 Iridium Member

    Reputation Points:
    Feb 1, 2005
    A friend of mine used to suffer from a bad case of arthritis in one of his knees. He found that after taking alpha-Ethyltryptamine. acetate that the pain was gone. This was back before a-ET was banned as a schedule I drug here in the USA. He consulted with his rheumatologist on this, who was very interested. My friend kept taking the a-ET on a weekly basis. In a few months, his chronic case of arthritis was gone for good.

    So, unfortunately, is legal access to a-ET.
  3. FrankenChrist

    FrankenChrist Iridium Member

    Reputation Points:
    Aug 20, 2004
    from belgium
    I saw this thing on TV (years ago, so don't bother asking for details) where this English guy who developed Parkinson's at a young age took XTC and suddenly he was able to do gymnastic and acrobatic moves again.
  4. Nnizzle

    Nnizzle Gold Member

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    Oct 4, 2007
    29 y/o from earth
  5. SpinKing

    SpinKing Newbie

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    Jun 25, 2008
    from U.K.
    BBC horizon 2000 ecstasy and the agony
    Can any1 find the video?