Melanotan II; a skin cancer cure turns out to be a strong afrodisiac

Discussion in 'Sex and Drugs' started by Alfa, Dec 10, 2006.

  1. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    Thin! Tan! Hotter Than Hell!

    Pharmaceutical labs are cooking up a new class of pills that make looking good feel better than ever.
    By Wil McCarthy
    It was chemical serendipity of billion-dollar proportions: a tanning drug with all the right side effects.
    A hundred years ago, being tan was bad, because it meant you worked outside, which meant you weren't rich. By the 1970s, tan lines had become associated with exercise, tropical vacations, and bumming around in skimpy clothing while others worked. Tan was cultural, tan was affluent, tan was healthy. UV-induced tan was also, unfortunately, the cause of a sharp rise in skin cancer rates and premature wrinkles.
    Hence a mid-'80s research push at the University of Arizona to attack the problem from inside. Being tan is healthy; ironically, people who work outdoors and see the sun every day are at low risk for skin cancer. But getting tan is where the danger lies. The faster it happens - worst case: a tanning booth - the more harmful it is. The U of A team, which included endocrinologist Mac Hadley and dermatologist Norman Levine, came upon a synthetic hormone a thousand times more potent than the body's own tanning triggers. They called it Melanotan and pinned high hopes on its sunless ability to protect, beautify, and gently fleece the pale peoples of the world.
    But that was only the beginning: The molecule turns out to activate five different chemical systems throughout the body. It's a potent anti-inflammatory, and in 1996 further tests of the drug showed that it also promotes sexual arousal. Not simple vascular stimulation, as with Viagra, but a direct action in the hypothalamus, the brain's emotional switchboard. Impotence is largely an organic, mechanical problem, but here was something that could potentially address the murkier issues of frigidity, and even that old-time marriage killer: simple lack of enthusiasm. (On Melanotan, female lab rodents triple their levels of courtship behavior.) And as if that weren't enough, the molecule also targets an appetite-suppression receptor popular with the makers of weight-loss drugs.
    Yesterday's drugs were about need; today's are about desire.
    Call it the Barbie drug: a pill or nasal spray that can make you thin, tan, pain-free, and horny all at once, without effort. How much would you pay?
    Melanotan is just a glimpse of the coming age of fantasy drugs - pills that will soothe (and, in fact, reinforce) social desires. In the days before tan was cool, overweight, depressed, bald, and impotent were merely descriptive terms, but today in America they're considered illnesses and are fought back with some $44 billion a year in direct medical expenses - fast approaching the $50 billion we spend battling cancer. And as the list of treatable disorders grows larger, so does our medical ability to reshape both body and mind. Yesterday's drugs were about need; today's are about desire. The unlocked human genome opens even our innermost passions to scrutiny and tinkering, blazing the way to an entirely new class of pharmaceutical. A more conservative, more religious culture than ours might want "doubt blockers" or "gnostogenics" to empower their spiritual side. But for better or worse, Americans who pay for quick-fix drugs will want beauty, happiness, and the illusion of wealth.
    Nowhere is this more apparent than in the world of bodybuilding. Let's face it, building muscle is hard work, and the people most intent on it are eager to speed the process. But steroids have troublesome side effects - like liver damage and violent behavior. Fortunately, the pharmaceutical industry rides to the rescue, with an injectable called Insulin-Like Growth Factor One, or IGF-1. This is a muscle-mass promoter that occurs naturally in the body, and whose slow decrease after age 30 is probably responsible for the wasting process we associate with aging. Shots of IGF-1 directly into muscle tissue have been shown to aid in muscle growth and to reverse wasting not only from old age but also from diseases such as muscular dystrophy. But the effect, which is localized at the injection site, soon wears off, allowing normal (or subnormal) muscle mass to return.
    Enter biotech, which can not only synthesize the protein from scratch but also package it in the form of engineered viruses that insert IGF-1 genes directly into muscle cells, allowing them to produce their own growth factor indefinitely. Researchers at the University of Pennsylvania have already created dozens of muscle-bound Mighty Mouse look-alikes from ordinary lab rodents. Injecting these viruses into people will be a slow, carefully monitored process, but it's only a matter of time before the street gets ahold of IGF.
    If Melanotan is Barbie's drug, then surely the IGF-1 virus belongs to Ken, who'll use it to build the pecs and lats she so adores, without filling up his calendar or wiping the sunny boy-next-door smile off his face. In fact, with both these drugs acting in concert, Ken and Barbie will be prettier than ever and have a lot more time to spend together.
    But what about Barbie's kid sister, Skipper? Locked in perpetual adolescence, too young for sex or drugs ... Does biotech hold any promise for her? Happily, yes: Food scientists in Garching, Germany, have developed a molecular big chill to turbocharge her snacks and soft drinks.
    Special nerve endings in the skin, and especially on the tongue and cheeks and palate, are designed to measure temperature and give a gentle (or not so gentle) warning when they come in contact with surfaces that are too hot or too cold. Our mouths know the difference between ice cubes and hot soup. Still, these nerves are chemical machines, and there are chemicals that can fool them. Capsaicin, the active ingredient in peppers, is "hot" because its precise molecular shape locks onto our heat receptors, triggering physiological reactions like sweating and flushing. Similarly, menthol - the distilled essence of peppermints - triggers a sensation of cold that deadens pain in the same way ice does.


    But menthol and capsaicin have very distinctive flavors and odors, which make them instantly recognizable and often offensive, even in tiny concentrations. The German molecule known as cyclic alpha-keto enamine, however, is a self-contained miniature ice age. It's cool to the touch and taste, like mint, but it produces a whopping 35 to 250 times the cooling sensation, with no intrinsic taste or smell. Large amounts of it can be added to anything. This could lead not only to bizarre new flavorings for Skipper to enjoy - SuperBerryIce and Hot Coffee Chiller, Megamint and even Frost Habanero - but also to cooling, time-release skin products for Ken and Barbie's day at the beach.
    Being shallow never felt so good.
    As the US grows more affluent, its cultural expressions have become more extreme, more competitive, one might say more professional. National cheerleading finals, recreational triathlons, octogenarian sex manuals ... Drugs have been a silent partner in the extreming of America, shedding their stigma and eroding the stigmas of the conditions they treat. Picture a cartoon spinach can in the pocket of every Popeye and Olive Oyl - and steroid poppers for every Bluto - and you begin to see just what fantasy is being realized here: the America of our collective inner child.
    Melanotan, originally licensed to Princeton, New Jersey's Palatin Technologies, has been shelved precisely because of its broad, potent action in the body. Palatin is currently pursuing a slew of receptor-specific chemicals instead - none of them cosmetic - while the original compound has passed into the hands of EpiTan Limited of Melbourne, Australia. In the land of Oz, high rates of skin cancer make tanning a major health issue, and Melanotan - now in human trials - is expected to be approved for prescription use in the next few years. But with worldwide rights to the compound, EpiTan has its eyes on the US market as well and will likely petition for FDA approval at the same time.

    The other chemicals are in a similar state - we'll be seeing them sometime in the next decade - and the development and legitimate market for their "fantasy" effects will take longer. But that's good; we can use the time to buy the beach houses and convertibles we're going to need. This decade is a breathing period, a chance to prepare for our cultural destiny: the drug-fueled extreming and professionalization of shallowness itself.
     
    Last edited: Sep 10, 2017
    1. 5/5,
      excellent find, WOW I want some!
      Dec 10, 2006
  2. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    [SIZE=-1] Superdrug for a dark, lean love machine


    [SIZE=-1] Jonathan Leake, Science Editor [SIZE=-1] BEAUTY and lust may soon come from the same bottle — of pills. A drug that gives users a deep tan, helps them to shed weight and raises their libido is to be tested in Britain.
    [SIZE=-1]The drug, Melanotan, has been developed as a protection against sunburn and skin cancer. It delivers a tan without exposure to the sun. But tests have revealed powerful secondary effects, including weight loss and a surging libido.
    [SIZE=-1] Some are touting the compound as possibly the most powerful lifestyle drug in existence. Others warn that its introduction would be a medical disaster, giving people a false sense of security about going out in the sun and actually increasing the cases of skin cancer.
    [SIZE=-1]Epitan, the maker of Melanotan, said it would first target the drug at the 10%-20% of people with sun allergies. But company documents for investors describe the drug as a potential “blockbuster” and detail plans to sell it more widely, aiming it at sunbed users, people planning holidays in the sun and those who work outdoors.
    [SIZE=-1]The firm said: “While more people are aware of the dangers of exposure to UV radiation, the desire to be fashionable outweighs their health concerns.”
    [SIZE=-1]Epitan is based in Australia and early trials were conducted on nearly 200 people at the Royal Prince Alfred hospital in Sydney. Australia has one of the highest rates of skin cancer in the world. Half its 20m population develops the disease at some point and about 1,000 people die from it each year.
    [SIZE=-1]Australian government agencies are studying the trials and could approve Melanotan for prescription this year or next.
    [SIZE=-1]There is likely to be similar interest in Britain, which has 8,000 tanning salons. Cases of skin cancer among Britain’s 60m population have surged to an estimated 100,000 a year, with 2,000 deaths annually.
    [SIZE=-1]Epitan plans to start trials in Britain and Europe this year.
    [SIZE=-1]Melanotan works by stimulating the production of melatonin, the pigment that suffuses the skin after exposure to the sun. The resulting tan can protect the skin against future exposures — but it can be maintained only by regular doses of sun.
    [SIZE=-1]Melanotan works in the absence of sunlight. An implant under the skin releases the drug over a period of weeks, conferring a tan that can last months.
    [SIZE=-1]Hunter Wessells, an expert in sexual dysfunction at the University of Washington in Seattle, is researching the drug. “It acts on neurones in the brain and spinal cord. It can also cause weight loss,” he said.
    [SIZE=-1]Palatin, an American drug company, is in clinical trials of a Melanotan-based drug that can be taken as a nasal spray before sex. Researchers think it unlikely that such sprays would lead to people becoming tanned as they would not be used every day. However, those using the implants to get a tan could experience frequent sexual arousal.
     
    Last edited: Apr 30, 2017
  3. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    [SIZE=+2]What is Melanotan and Melanotan II?

    Based upon a quote of the Arizona Cancer Center found at sunless.com (on June 14th,1999):

    Melanotan and Melanotan II are both synthetic versions of melanocyte stimulating hormone that were created, synthesized and developed at The University of Arizona and the Arizona Cancer Center. Melanotan is a linear, full length peptide (containing all 13 amino acids). Melanotan II is a shortened, circular version of the same peptide. Both Melanotan and Melanotan II have sunless tanning capabilities but because Melanotan II had labido enhancement and spontaneous erections as side effects, it is now being developed as a sexual and erectile dysfunction drug.

    To be particularly clear regarding Melanotan (due to previous incorrect news reports) it should be known that it does not cause sexual arousal nor have erectile effects. These aspects are only found in Melanotan II and bremelanotide.

    [SIZE=+2]Who created them?

    The Arizona Cancer Center located at The University of Arizona.
     
    Last edited: Sep 10, 2017
  4. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.


    PELVIPHARM Laboratories, CNRS, Bat 5, 1 avenue de la Terrasse, 91190, Gif-sur-Yvette, France.
    Melanocortins have been reported to play a role in the control of both male and female sexual behavior. The present study examined the effects of melanotan-II (MT-II), a cyclic peptide analogue of alpha-melanocyte stimulating hormone on appetitive and consummatory aspects of female sexual behavior, including aspects of sexual proceptivity (solicitations, hops and darts, ear wiggling, pacing) and receptivity (lordosis). One group of ovariectomized Long-Evans rats (n=7) was primed subcutaneously with estradiol benzoate (EB) and progesterone (P) (10 mug and 500 mug respectively) and another group (n=7) with EB (10 mug) and oil (EB alone). Paced mating tests were performed with sexually experienced males in unilevel chambers, which were bisected by a Plexiglas divider containing three holes, through which only the female could pass. MT-II (1 and 3 mg/kg) or saline was injected intravenously 10 min before each 30-min paced mating test. Each female received the 3 treatments. In females primed with EB+P both doses of MT-II increased the number of hops and darts and ear wiggling significantly, but did not alter pacing or lordosis. With EB alone, no effect of MT-II was observed on any of the parameters measured. These results suggest that P can interact with MT-II to increase proceptive behaviors. Because hops and darts are essentially solicitations, made in close proximity to the male, that indicate a desire on the part of females to receive mounts and intromissions, these data suggest that activation of melanocortin receptors may represent a promising mode of action for the treatment of women with hypoactive sexual desire.
    PMID: 17113634 [PubMed - as supplied by publisher]
     
  5. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat.


    Pelvipharm Laboratories, CNRS, Bat 5, avenue de la Terrasse, 91190 Gif-sur-Yvette, France. [email protected]
    The effects of melanotan-II, a non-specific agonist of melanocortin receptors, on erection and its possible sites of action were investigated in anesthetized rats. Delivered i.v. (0.1, 0.3 and 1 mg/kg) or within the paraventricular nucleus of the hypothalamus (0.1 and 1 microg), melanotan-II exerted a dose-dependent inducer activity on erection by eliciting erectile events and shortening latency of the first erectile event to occur. Erectile events were of higher amplitude in rats treated with melanotan-II i.t. (0.2 microg) delivered at the L6-S1 level than in animals treated with the vehicle i.t. delivered. Erectile responses elicited by cavernous nerve stimulation were increased after i.v. melanotan-II (1 mg/kg), thereby exerting facilitator effect on erection. In contrast, melanotan-II injected within the corpus cavernosum (1 microg) did not display any facilitator activity. To investigate the neural pathways involved in the facilitator effect of melanotan-II, we performed acute spinalization (T8 level) and differential selective nerve transections. Neither spinalization nor bilateral transection of pelvic nerves or dorsal penile nerves impaired facilitator activity of i.v. melanotan-II (1 mg/kg). Conversely, the facilitator effect of melanotan-II was abolished after acute removal of the lumbar paravertebral sympathetic chain. These results lead to the conclusion that central and peripheral melanocortin pathways are recruited by melanotan-II, depending on its route of delivery, to exert both inducer and facilitator activities on erection.
    PMID: 16360286 [PubMed - indexed for MEDLINE]
     
  6. joechip666

    joechip666 Titanium Member

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    Alleged L.S.D. producer William Leonard Pickard has expressed concern about the social ramifications of a chemical cousin of Melanotan II, Bremelanotide (PT-141).
    A WORD OF CAUTION ON BREMELANOTIDE (PT-141)
     
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  7. ~lostgurl~

    ~lostgurl~ Platinum Member & Advisor Donating Member

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  8. blinkKDX

    blinkKDX Newbie

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    I has used Melanotan II for its tanning properties and after a SQ injection swim notices random hard ons for a couple of hours.
     
  9. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    Did You experience an increase in lust?
     
  10. blinkKDX

    blinkKDX Newbie

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    there was some...

    there is another drug PT-141 that was produced from melanotan II that is specifically for sexual effects.

    swim beleives he saw a post from either You or someone else already around here on it.
     
  11. ~lostgurl~

    ~lostgurl~ Platinum Member & Advisor Donating Member

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    FDA Halts Sale Of Libido-Increasing Injectable Tanning Drug

    FDA Halts Sale Of Libido-Increasing Injectable Tanning Drug

    6 September, 2007
    The Consumerist, NY

    Melanotan.jpg

    The FDA has warned Melanocorp, Inc., of Tennessee to stop its online sales of Malanotan II, an injectable tanning product that the company claims is "effective in protecting against skin cancer and rosacea."

    According to the FDA, such claims cause it to be "classified as a drug under the Federal Food, Drug and Cosmetic Act, as well as a new drug because there is no evidence that it is generally recognized as safe and effective for its labeled uses."

    Melanotan II and its precursor, Melanotan, were developed by the University of Arizona in the 90s as a possible way to prevent sun cancer, by triggering the sort of protective tan that otherwise takes weeks of steady UV exposure to generate.

    Side effect include increased arousal—in one study, it caused erections in 80% of participants—and reduced appetite, which is why the media promptly dubbed it the "Barbie Pill."

    As of this afternoon, Melanocorp.com is serving up a blank page.

    http://consumerist.com/consumer/tan...increasing-injectable-tanning-drug-297222.php
     
  12. dutch-marshal

    dutch-marshal Palladium Member

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    tanning drugs...,
    people are so hollow... :(
     
  13. freekdl

    freekdl Newbie

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    ^^ You wouldn't say such things if he was skin type 1 and has been *white* all his life.. Being white all summer, going on vacation to great places and not even getting the slightest tan. Very cool to see the pictures afterwards..

    I ordered it from the UK last July and it still works for me! It's like I'm completely sun-proof now, I don't get burned anymore, even without protection..
    Even without sun (weather is really bad here at the moment) I'm not as white as I used to be and a little tan looks a lot healthier in my opinion.

    Bottomline, this stuff has made a big difference for me and I will use it again every summer.
     
  14. tinytom

    tinytom Newbie

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    Humm i have to disagree i know a few bodybuilders that use melotan coming up to a show.