Drug info - Metabolism of the recently encountered designer drug, methylone, in humans and rats

Discussion in 'Beta-Ketones' started by enquirewithin, Sep 26, 2006.

  1. enquirewithin

    enquirewithin Gold Member

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    Authors: Kamata, H. T.; Shima, N.; Zaitsu, K.; Kamata, T.; Miki, A.; Nishikawa, M.; Katagi, M.; Tsuchihashi, H.

    Source: Xenobiotica, Volume 36, Number 8, August 2006, pp. 709-723(15)
    Publisher: Taylor and Francis Ltd

    Abstract:
    The urinary metabolites of methylone in humans and rats were investigated by analysing urine specimens from its abuser and after administrating to rats with gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-electrospray ionization mass spectrometry (LC-ESI MS), using authentic standards. The time-course excretion profiles of methylone and its three metabolites in rats were further investigated after a single intraperitoneal dosing of 5mgkg −1 methylone hydrochloride. Two major metabolic pathways were revealed for both humans and rats as follows: (1) side-chain degradation by N -demethylation to the corresponding primary amine methylenedioxycathinone (MDC), partly conjugated; and (2) demethylenation followed by O -methylation of either a 3- or 4-OH group on the benzene ring to produce 4-hydroxy-3-methoxymethcathinone (HMMC) or 3-hydroxy-4-methoxymethcathinone (3-OH-4-MeO-MC), respectively, mostly conjugated. Of these metabolites, HMMC was the most abundant in humans and rats. The cumulative amount of urinary HMMC excreted within the first 48h in rats was approximately 26% of the dose, and the amount of the parent methylone was not more than 3%. These results demonstrate that the analysis of HMMC will be indispensable for proof of the use of methylone in forensic urinalysis.

    Document Type: Research article
    DOI: 10.1080/00498250600780191
    Affiliations: 1: Forensic Science Laboratory, Osaka Prefectural Police HQ, Osaka, Japan


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    Last edited by a moderator: Jan 13, 2010
    1. 5/5,
      great article
      Sep 28, 2006
    2. 5/5,
      good information
      Sep 26, 2006
  2. Cuberun

    Cuberun Gold Member

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    I wish I could understand what that means as it seems interesting :)
     
  3. Nagognog2

    Nagognog2 Iridium Member

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    1. It will give us an idea of how methylone does what it does in the body, and how it is broken down, and where, and excreted.

    2. It shows us the medical profession is taking an interest in this substance - which may have both positive and negative consequences.