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Drug info - Methamphetamine vs. Dextroamphetamine

Discussion in 'Amphetamine' started by Roads, Mar 25, 2010.

  1. Roads

    Roads

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    SWIM has tried searching for a thread that detailed a milligram-to-milligram comparison between the two, but couldn't really find one, Google didn't help much either, so his apologies if this is a re-post. w/e

    Similarly, heroin is often compared to morphine and is said to be 2-3 times "stronger", and there are charts on the internet that compare opiates using morphine or codeine as a base, so SWIM's questions are:

    How many times more potent is a dose of meth. vs the same dose of D-amphetamine? Also, is there any kind of chart or diagram somewhere on the net that you SWIMmers may know about that compares the various stimulants (nicotine, caffeine, ritalin etc) to each other?
     
    Last edited: Mar 25, 2010
  2. fizzle

    fizzle Silver Member

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    Swim does not know much about meth, but would assume that for the most part it is cut with something, so doing a mg to mg comparison would be very difficult. Perhaps a Desoxyn (prescription meth) compared to dextroamphetamine would be a more accurate comparison. Sorry Swim can't provide much else, but here is a thread that might help:

    http://www.drugs-forum.com/forum/showthread.php?t=21828
     
  3. 100mg Methylphenidate

    100mg Methylphenidate Silver Member

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    Im pretty sure methamphetamine is about twice as potent as dextroamphetamine dosage wise.
     
  4. allyourbase

    allyourbase Palladium Member

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    quite the opposite. recreational methamphetamine doses start around 20 mg; whereas one can feel as little as five mg of d-amphetamine. the primary difference is the onset and duration. methamphetamine has both a longer onset and a longer duration as it has to be processed metabolically. "peak" duration for dextroamphetamine vs racemic methamphetamine is at least an hour longer (in swims experience). methamphetamine seems to occupy a rather unique space as an analog of amphetamine, any longer of a chain at the nitrogen and it would lose both duration of action and further lose potency.
     
  5. Roads

    Roads

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    SWIM has seen surveys of how pleasurable normal activities are vs. how pleasurable meth is, and everyone rates meth at 10 and sex at a 2 or 3. SWIM has experienced D-amphetamine many times... but has never felt like it was really THAT amazing. So what is it that makes methamphetamine so pleasurable?
     
  6. Impure157

    Impure157 Silver Member

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    SWIM would have to disagree with those ratings but that might be because he has never smoked his meth. Even the highest quality product he's ever found was extremely fun, more euphoria, faster onset, longer duration, less harsh crash, than dextro-amphetamine but not better than sex or anything that drastic.
    An educated guess would have to be that when smoked/injected it is that massive near instantaneous release of dopamine that causes people to say it's better than sex, whereas if orally ingested or insufflated the release of dopamine takes longer so you don't get that rush of euphoria.
     
  7. onzero

    onzero Silver Member

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    as far as dopamine uptake is concerned, methamphetamine is about 1.2-1.5x as potent, but methamphetamine is also strongly serotonergic so it takes a higher dose to feel as "tweaked"

    methamphetamine is a "softer feeling" drug (mg for mg) because of the serotonergic action's softening/smoothing/balancing of the dopamine and norepinephrine release.

    a lot of people w/ADHD who get prescribed desoxyn after adderall or dexedrine are underwhelmed, find it rather "weak" in its motivational and focus enhancing effects. the serotonergic action of the drug regulates the dopaminergic action, but when you get into higher recreational dosages you get a large release of both which is very euphoric. desoxyn is great because it is relatively free of the obnoxious side effects of standard stimulants like insomnia, mood swings, irritability, dehydration, which makes it a good option for daily use and doesn't "force" focus, but allows the user to have better control over his natural focusing mechanisms, but if you want to pull an all nighter, you're better off with plain old dexamphetamine because of the more "unregulated" dopamine/norepinephrine release..

    this may seem like hocum, but i assure you it isn't, just consider most who take dexies or adderall are taking maybe 10-30mg at a time to get pretty ramped up (with newb tolerance) while that figure is probably much higher for methamphetamine depending on the purity of the sample, and why weak or shit methamphetamine is rather underwhelming as well, and may be better suited as a "mood enhancer" than a recreational drug.
     
  8. Demosthysias

    Demosthysias Newbie

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    Swim has never tried meth. and swim has ADHD. but swim has taken up to 60mg of adderall(orally) and 30mg (insufflated). and at that dose was just in a really good mood and didnt sleep or eat for a few days. Swim is very very curious as to how meth would affect him, knowing this. Will it take a lot more than most people to geek me out? As to swiys question, swim is useless due to my lack of experience with meth. swim is curious tho.
     
  9. Crystal_Queen

    Crystal_Queen Silver Member

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    Morphine, Heroin, Dextroamphetamine are all "salts" therefore they can easily be
    compared. Meth is unique being a "crystal" is probably weaker orally but much much,
    stronger if smoked or injected. Crystals are like ultra dense salts...like glass and sand...
    no cracks or air inside. if you extracted 10mg of desoxyn you would have a tiny little spec hiding in that pill
    lol...
     
  10. tulanthor

    tulanthor Silver Member

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    1.2-1.5x is a good estimate that I hear a lot. This is for 3 reasons, 1) methamphetamine is more difficult to be metabolized by your body, so your serum concentrations are higher for longer, 2) methamphetamine is (somewhat) metabolized into regular amphetamine which will prolong effects, and 3) meth has a smaller molecular weight (by about 45 g/mol) so you need less mg of meth to get the same number of moles.

    Crystals can be water soluble. Sugar and salt are both crystals. The oral bio availability of meth (according to wiki) is about 63%. Compare this to a 20-40% bio availability of morphine (which is typical of opiates). Relatively speaking, meth is great to be eaten. And technically speaking, morphine heroin, d-amph, and d-meth can be in salt or freebase form, while glass is an amorphous solid and sand (mainly quartz) is a water insoluble crystal. Meth is unique in that when it's a hydrocloride salt it crystallizes very nicely. However, it's still a salt and still soluble in water (thank god).
     
  11. Crooked_AMP_1993

    Crooked_AMP_1993 Newbie

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    I'm no pharmacologist but when SWIM tried desoxyn (Dextromethamphetamine) compared to the regular Dextroamphetamine (5mg IR) desoxyn had a shorter duration, more euphoria, no ability to focus, mild hallucinations,paranoia and was hyper as fuck, horrid comedown,to get high Desoxyn is awesome, to focus Dexedrine is better. As far as street meth goes quality and purity vary, so swim stayed far away from that.
    To chill out and stay up: Dexedrine (dextroamphetamine
    To party and go wild for 5-6 hours do methamphetamine.
    Besides where swim resides, meth is like blacklisted from any dealer in town (gangs run the drug industry, and oddly enough the biker gang that controls swims towns illegal drug market, proclaim constantly about the dangers of meth. And Since swim is Canadian, Desoxyn is not prescribed to anyone.
     
  12. dextro user

    dextro user Newbie

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    I know this thread is several years old, but I have to add my 2 cents worth.
    Firstly there is no such drug as "dextromethamphetamine". Hopefully that was just a typo on a previous post.
    There are dextroamphetamine and methamphetamine.
    The only thing they share is "amphetamine".
    Though both are addictive, Meth can deform and ultimately kill the user.
    Dextroamphetamine (generic dexadrine) is simply "speed". It's given in tablet and spansule (Extended Release) form.
    The usual penalty for an overdose of dextroamphetamine is hives. It rarely causes any lasting damage in an otherwise healthy person.

    Dextroamphetamine is to Meth what 6% beer is to Kentucky Bourbon.
    Both are amphetamines...both are alcohol.
    They share no other characteristics.

    My biggest gripe is the current scare over anything with amphetamine in its name.
    As a user of Dextroamphetamine for 15+ years for severe ADD I tire of being treated like a criminal.
     
  13. RatchetJaw420

    RatchetJaw420 Newbie

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    this isn't true...methamphetamine AND amphetamine both have left and right stereo isomers..dextromethamphetamine and levomethamphetamine
     
  14. Diverboone

    Diverboone Titanium Member Donating Member

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    15 years of Dextroamphetamine use and this is all the knowledge you have gained? Practically everything you stated is incorrect. Please take the time to learn about a subject before you make statements that castrate your intelligence.
     
  15. RatchetJaw420

    RatchetJaw420 Newbie

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    Exactly what I was thinking....I really hope that you're lying about having 15 years experience with dextroamphetamine. With that experience, an interest to learn about the chemicals you are using, and enjoyment of using psychoactive drugs....you should know how amphetamine and methamphetamine are related, and you should know that they both have 2 stereo isomers which are drastically different from one another in effects, despite the fact that they are both still amphetamine/methamphetamine. Dextroamphetamine and dextromethamphetamine is the "recreational" isomer because it is the one that produces all the euphoria, increase in libido and boosted self esteem/confidence. Now the other isomer, levoamphetamine/levomethamphetamine....causes more of the decongestant, central nervous system etc. unwanted effects. So think of this....you can get "fake" dope that's not TECHNICALLY fake, but it really is lol levomethamphetamine IS true methamphetamine that will come back positive on any road side test, lab analysis because it is actually real methamphetamine...it's just the shitty non recreational isomer of meth. Unfortunately the ingredients to produce levomethamphetamine are cheaper and easier to come by because it doesn't require pseudo ephedrine/ephedrine to make. Pure DEXTROMETHAMPHETAMINE is what you want to recreationally get spun out of your skull.