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TEK - Methylphenidate Purification TEK (Ritalin/Methylin Pills)

Discussion in 'Concerta & Ritalin' started by tjk13, Aug 1, 2010.

  1. tjk13

    tjk13 Silver Member

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    Hello SWIY's that share an enjoyment for the Up's-

    Purifying MPH

    1) Generic Ritalin is crushed into a fine powder.

    The pills (Small round white, "10" on one side, "M" on the other) SWIM used contained:

    -Methylphenidate (MPH, 10 mg. Soluble in EtOH and H2O)
    -Lactose Monohydrate (Not soluble in EtOH, soluble in H2O)
    -Magnesium Stearate (Not soluble in either EtOH or H2O)
    -Microcrystalline Cellulose (Not soluble in either EtOH or H2O)
    -Talc (Not soluble in EtOH or H2O).

    It is therefore obvious that warm EtOH should be our solvent of choice, and it confuses SWIM why so many TEKs online choose H2O as the solvent. Water would most likely dissolve some lactose monohydrate, which rules it out as a choice solvent.

    EtOH (as one should recognize as Ethyl Alcohol, or Ethanol) is obtained from high-proof (95% by volume, 5% water) drinking grade grain alcohol. Keep in mind that some US states do not allow the sale of ethanol for drinking purposes, such as brand-name Everclear.

    2) Place crushed pill material in a coffee filter. Place filter+powder in a large funnel.

    3) Using a hot plate, heat EtOH to a suitable temp, around 150 F should be OK for this, considering MPH is quite soluble in room temp EtOH.

    4) Pour EtOH over pill mass and collect the ethanol/MPH mixture in a glass baking dish.

    5) Evaporate using SWIY's favorite method of evap, but keep in mind that SWIY is evap'ing ethanol, so don't be a Fuck and use your stove or oven. Please use caution. A slow evap is not only safer, but it will retain more of the active goodies in the final product.

    Try using a grow-light (from a hardware store, $20) and a fan to speed up evaps.

    6) SWIY should be left with a white crystalline powder that crushes easily (once fully dried).

    This powder goes hand-in-hand with nasal administration because the water-insoluble crap has been filtered out, leaving only the HCl salt of MPH which is easily absorbed through your nose.

    Say goodbye to talc boogers and clogged sinuses :thumbsup:

    Theoretical yield from using 20 of the 10 mg instant release Methylin (R) brand pills is 200 mg. SWIM usually obtains 100-130 mg from the first filtration, 50 mg from the second, and a lesser amount from the third.

    Highly efficient method of purifying one's ADD pills for a more recreational (and healthy, if used nasally) effect. It also opens the door for the conversion to Ethylphenidate now that SWIY has a clean product...

    I will post the TEK soon ;)
     
  2. User-126494

    User-126494

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    SWIM's hamster uses ethanol for dissolving and then re-crystalizing his rock candy.

    He finds it especially handy to do the evaporative re-crystalization on some form of Teflon baking tray or pan. The crystals just slide right off with minimal effort.

    If SWIY wanted to they could remove the 4-5% water from the ethanol by using Magnesium Sulphate(MgSO4, Epsom Salts), as a drying agent. There are numerous TEK's on this and would encourage SWIY's hamster to UTFSE to look-up more information regarding water removal. That is, of course if the hamster is a perfectionist…

    Share knowledge, be safe, be well...
     
  3. tjk13

    tjk13 Silver Member

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    Good suggestion Wanderer, if you don't mind SWIM asking, does SWIY's hamster have a script, and if so, what are the inactive binders/fillers in SWIY's hamster's candy?

    SWIM will try this re-crystallization tonight.
     
  4. User-126494

    User-126494

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    SWIM remembers the hamster posting something like this. Mostly to remove mannitol from his candy. But it works with anything which is not ethanol soluble…
    SWIM's hamster is running the wheel right now, but hope this helps clean SWIY's hamster's candy.

    Be well...
     
    Last edited: Dec 11, 2010
  5. freedomf

    freedomf

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    swim have a question can swim do that with concerta ?
     
  6. Kiddycrack

    Kiddycrack Silver Member

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  7. silverh

    silverh

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    SWIM's least favorite keebler elf is going to have a chance to try this extraction in a few weeks. He tells me that he plans to refine the ETOH using MgSO4, and will use a glass separatory funnel and chemical filter to collect the goodies. It may be overkill, but this elf strives to use the finest toys available to reduce the risk of unwanted contaminants and rule out his clumsiness. :laugh:

    The little guy has done a few extractions in his time, but not on this substance. He tells me that he is going to hold a little of his supply back in case things go awry, and will commit the reminder if all goes well. He will post results and possibly a trip report when it's all said and done, and would appreciate any additional suggestions that those more thoroughly acquainted with this may have.
     
  8. silverh

    silverh

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    Mr. Keebler sent me a telegram recently saying that the extraction was successful. He went on to say that he took some liberties with this TEK in the interest of harm reduction, and he wanted to share those along with some other helpful suggestions on this process in general.

    He feels like the safest change he made to this TEK was using cold versus warm Ethanol. He likes working from his cozy little tree house whenever he can, and he didn't want to start a fire there in the process of heating alcohol. Instead, he pulled his fuel from straight out of the freezer and this seemed to work admirably. The yields and evap time do not appear to be effected, but that does not make the extraction totally safe by any means. Slightly colder or not, working with pure or near-pure alcohol is dangerous so he took careful precautions with it.

    For tools he says that he used a standard glass funnel instead of his trusty sep. It just wasn't going to be useful for this TEK, but his funnel stand did come in quite handy. He also tried using glass and teflon-coated trays for the final collection and drying. As SWIwanderer already mentioned, the goodies are notably easier to remove from the teflon trays. Glass trays are fine too, but some of the product will inevitably stick like herpes and a sharp scraper or razor blade will be needed to get it all removed. The Keeb tells me that he really doesn't like handling sharp tools, especially while upping, so he will be sticking to teflon, pun intended.

    He also used two filters in the funnel, and he tried a technique he has used in other extractions with great benefits. What he did was he made the bottom filter cone-shaped, and then he placed a flatter, more bowl-shaped filter about 2 inches above it. The crushed powder was placed in the "bowl" filter and spread around, and the EtOH was poured in and stirred occasionally with a rod as it drained through.The green man likes that it not only allows him to mix the product more thoroughly and maximize his extractions, but the lower cone filter always has some goodies left on it after it has dried for a bit. The more extractions that are done through the lower filter, the more goodies it will have for SWIU, so Bon Appétit! :thumbsup:

    Overall he couldn't be happier with the results, just be safe! :)
     
  9. bketros

    bketros Newbie

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    SWIM was wondering if anyone has a suggestion for obtaining suitable EtOH if Everclear is not sold where they live?
     
  10. Zainal

    Zainal Newbie

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    marine alcohol or any denatured ethyl

    95% ethyl alcahol
    5% methyl
    the methyl can be boiled out simply by getting the solution to a good boil for a couple minutes as the methyl has a lower boiling point

    or so someones dad told me was the secret for making moonshine smooth and non hangover producing

    almost pointless if you are evaporating in an oven at 215 deg F is it not?
     
  11. User-126494

    User-126494

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    The hamster would like to add that while it is true any sort of alcohol may be used, but please pay special attention to step 7 in Mr. Hamster's TEK post where he says to grind the crystals as finely as possible and allow them to "air out" for 24-48 hours. This will allow any alcohol or other volatiles to evaporate, especially if using methanol (MeOH), isopropyl (IPA), or denatured alcohol which might have been trapped in the crystal matrix as it formed.

    Be safe, be well...
     
  12. User-126494

    User-126494

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    Mr. Hamster decided to go back and re-write this with updated information based on the OP as well as some of the additional posts. The hamster has concluded the best form of methylphenidate extraction from Ritalin IR, Methylin, and other instant release formulas is this method. Thanks to SWItjk13 posting in the first place and asking Mr. Hamster if he could help out. The purpose is to remove several additives from the pills and demonstrate how easy evaporative recrystallization is. Typically these:


    • Methylphenidate (MPH, 10 mg. Soluble in EtOH and H2O)
    • Lactose Monohydrate (Not soluble in EtOH, soluble in H2O)
    • Magnesium Stearate (Not soluble in either EtOH or H2O)
    • Microcrystalline Cellulose (Not soluble in either EtOH or H2O)
    • Talc (Not soluble in EtOH or H2O)

    We'll use ethanol since none of the additives are soluble in ethanol and the methylphenidate is. Water is the worst choice here.

    Materials:

    • Coffee filters or filter paper.
    • Some methylphenidate tablets/capsules or others (assume 20 x 10mg tablets).
    • Some 95% Ethanol (Everclear if you are in a place which has it, or "Spiritus" Polish Vodka 96% ethanol, or reagent grade EtOH). NB: Other alcohols will do, they are just toxic and time must be allowed for the crystals to fully dry and let any other alcohols trapped in the crystal matrix to fully evaporate. The key here is as little water as possible. See here for more information regarding solubility and varying percentages of ethanol Solvent Solubility Worksheet originally created by Zeni. It's for cocaine solubility, but can assist with this as well.
    • Stirring implement - glass rod, spoon, knife, etc...
    • Glass measuring cup, beaker, or graduated cylinder.
    • Glass to hold filter paper in.
    • Top quality Teflon pan, wide is best.
    • Stove with inductive heating or electric heating elements. NO OPEN FLAME!
    • Working overhead ventilation fan.
    • Bendable plastic card.

    Procedure:

    1. Grind the 20 x 10mg tablets into as fine a powder as possible. Use some imagination here, but make sure no powder is lost. The finer the better with dissolving.
    2. Measure 100ml ethanol into the beaker or measuring cup. This assumes 5mg/10ml ratio.
    3. Warm the ethanol in the microwave for approximately 30 seconds on high. This will warm the ethanol making the methylphenidate easier to dissolve.
    4. Add the powder to the warm ethanol and stir. Make sure there are no small "pebbles" in the solution.
    5. Let sit for a few while preparing the filter paper.
    6. Fold the filter paper into a 4-square fold, and cut the filter making it as large and round as possible.
    7. Unfold and between two of the 1/4 folds, fold a 1/8th fold, then holding the two 1/4th folds together and the 1/8th outside, fold the 1/8th along the outside. This will give a large surface area (less clogging and ease draining). For more information on folding filter paper see here: Folding Filter Paper
    8. Place the filter paper in the receiving glass beaker, glass, etc.
    9. Pre-moisten the filter paper to prevent wicking of any active ingredients into the filter paper.
    10. Stir the solution again making sure there are no pebbles and everything is in solution or suspended in solution making it cloudy.
    11. Filter the solution using the filter set up in step 7-9.
    12. Wait until all the liquid has passed through the filter.
    13. Repeat steps 2-12 using any substance left in the original beaker, scrape and rinse the filter paper with ethanol into the it as well. (Just doing a second pass to get anything left behind.)
    14. Place the Teflon pan on the electric heating element.
    15. Turn on the exhaust fan. (EXTREMELY IMPORTANT)
    16. Fill the pan with the filtered liquid.
    17. turn the heat to "Low -> 1". Some experimentation is required, do not let the ethanol boil, just get it to the point just before boiling.
    18. Let the ethanol completely evaporate. Should be fairly quick, maybe 1-2 hours for 200ml.
    19. Admire the pretty crystals.
    20. Scrape the crystals off the pan using the bendable card and empty them onto an appropriate surface.
    21. Make sure they are ground as finely as possible to allow any liquid trapped in the crystal matrix to evaporate.
    22. The product is ready to use immediately since ethanol is non-toxic, but for best results allow to dry for 24-48 hours.
    23. When dosing be extra careful in weighing the dose and metering it out. This should be almost 100% active ingredients, so 10mg will be a lot less than a crushed 10mg tablet.
    24. The resulting dose(s) may be administered by a hamster or chinchilla's favorite ROA.
    Mr. Hamster hopes this has been educational and taught a few things about evaporative recrystallization. He just used the methylphenidate, but this same technique can be used to make rock candy using sugar put into solution with water.

    Be well...
     
    Last edited: Dec 19, 2012
  13. beccag

    beccag Newbie

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    switjk13, swim has not been able to find the TEK mentioned for conversion of MPH to ethylphenidate. If he could post this TEK, it would be greatly appreciated!
     
  14. tjk13

    tjk13 Silver Member

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    Wanderer's cleaned-up version of Mr. Hamster's TEK is the best tek for MPH purification I've found on the interwebs. Bravo and cheers!
    I feel the need to mention, however, that if SWIY chooses to microwave ethanol, BE VERY CAREFUL and do not leave the powered-and-running microwave unattended! Ethanol evaporates MUCH faster when heated, and alcohol vapors are (obviously) extremely flammable. SWIM knows jungle cats who have ruined/ignited kitchen appliances in similar fashions.

    Keep checking back in the PEA chem forums for the MPH to EPH TEk, its coming soon. I'm somewhat surprised nobody has posted one yet.
     
  15. beccag

    beccag Newbie

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    Swims' next door neighbor's, brother's, grandfather's cat uses anhydrous IPA for the MPH extraction, as he found it difficult to get Ethanol completely dry. With the dry IPA, and thick paper in the Buchner funnel, that cat gets within 10mg of ideal MPH on a 100mg (10x10mg tabs) pull. With the 95% ethanol, he was getting 20-30% higher weight than ideal and that was with room temp, and heavy filtering. He thinks heating will only allow more fillers into solute, and in fact, he found that with the ethanol it was better to chill in freezer before filtering.

    That cat said he was surprised that switjk13 had not already posted the MPH to EPH Tek as he saw a post indicating successful conversion. Cat said he played with ethanol and HCl in reflux to convert, but doesn't know the proper HCl quantity, so he is checking DF forum with tingling anticipation....
     
  16. User-126494

    User-126494

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    Mr. Hamster is very busy at the moment, but he wanted to caution anyone against using an open flame to evaporate methanol (or any other flammable substance for that matter).

    Ethanol, or any other alcohol will evaporate at room temperature. Adding a bit of heating in the form of an electric hotplate or such will speed the process. Also, alcohols are azeotropes, so a chinchilla or hamster should expect to have some water mixed in as well. The alcohol will evaporate quickly, but it may take a while for any water in the mix. Low heating will help this.

    Be very careful if using a heat source for evaporation and make sure there is plenty of ventilation and no open flames.

    The plenty of ventilation rule would sort of eliminate the microwave as an option. It is a small enclosed space where the alcohol vapors will accumulate, and this could be explosive. Additionally, microwaves typically have motors in them for fans, rotating table, etc. These motors could cause a spark which could ruin a gerbil's day, week, month or worse. Microwave oven evaporation of flammable liquids or solvents is highly dangerous and should be avoided or risk serious injury even death to one's self or occupants of the room or structure.

    DO NOT USE THE MICROWAVE FOR EVAPORATING FLAMMABLE LIQUIDS!


    Mr. Hamster just wants to make sure all the other hamsters, chinchillas, and gerbils stay safe.

    Also, ethylphenidate is not something hamster can just whip up in the kitchen. It is the product of transesterfication of the methylphenidate and ethanol in the body performed by the liver in a similar manner to cocaethylene. One should be careful of this and avoid mixing alcohol with methylphenidate (or cocaine for that matter) as it's much more stress on the cardiovascular system.

    Be well...
     
    Last edited: Feb 1, 2011
  17. ratatata

    ratatata Silver Member

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    mr hamster, perhaps you could help my cat, your hamster seem very knowledgable about mph and extractions

    my cat is sorry if this is a long post but he figured that as the end result is the problem, if it wasn't the presence of corn starch, which he can't find if it is soluble in alcohol, it must be some part of his process. help would be greatly, greatly appreciated!

    my cat has 10 mg focalins. he figured that the binders were very similar (the only one he can remember that is different is corn starch) and the active ingredient is half the same, so he tried the same tek but not maybe to the book

    he did small extractions, 20mg and 10mg, and found the same issue in the end both times

    he ground his pills fine, put them into a small metal shot glass, and added a bit of 72% isopropyl alcohol, all that was available. he stirred this with the bottom side of a plastic paintbrush, let it sit, re stirred, let it sit, for maybe 3-4 minutes. the did not have a realistic way of warming the ipa but he figured he could just do multiple pulls and saved the left over powder.

    he strained this liquid into a medicine bottle with a torn coffee filter kind of pushed into it a little bit but also wrapped around the sides as to not let any binders fall in. he let it drain as much as it would, and then after it started to slow/stop, would swirl the contents/binders which he figured was blocking any more ipa to drip. after doing this for a while, he would gingerly pick up the filter, as to not let anything spills, and squeeze it gently to force out the rest of the IPA

    he poured the clear liquid into a clean altoids tin, as he didn't have an appropriate glass or pyrex container, and let it dry. mostly just by it sitting there, but then later took a heating pad for my cats neck, turned it on high (it only goes to about 170 or something my cat thinks), and let the altoids tin rest on top of it. when touching it it only seemed to get warm but it did help speed up the evaporation

    after dry, he used an exacto knife to scrape hard to remove crystals and a plastic credit card to remove as many as he could

    here is the problem:
    he got a crystallin substance in the end, little shiny shards, but they were kind of brown. there is also some amount that is stuck to the edges that was/is difficult to remove. but mainly he is concerned as to why his end product is brown. he couldn't have burned it, he thinks, as he used such little heat.

    my cat realizes focalin is different from ritalin but as it is just pure d-mph as opposed to racemic mph he figured that meant that the crystals should look the same. could it be reacting with the altoid tins metal? the shot glass? could a binder have gotten through? my cat isn't sure, and is concerned because after using it, it did feel the same/came on stronger and faster than a simply crushed focalin, but figures if its something more than simply an extra binder being extracted, that could not be safe


    my cat would be EXTREMELY grateful for any ideas anyone has, he'd like to start purifying his focalin and putting it into a nasal spray container, but it concerned about the color of his results
     
  18. User-126494

    User-126494

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    Mr. Hamster would be interested to know if white or brown coffee filters were used. He's seems to think that the brown filters, while made to appear "eco-friendly" by not using bleaching agents to make them white, are actually colored brown. This could be a source of some of the coloration.

    Another source of concern the hamster has for the cat is that the cat is using an "altoids tin" to perform the recrystallization in, along with the high water content in his ethanol. He seems to think that some otherwise ethanol insolubles are getting through, which might include the cornstarch.

    Heating at a high enough temperature might cause some caramelization of any sugars, and possibly the cornstarch. These might have passed through due to the water content.

    Another potential source could be reactivity between the water and the altoids tin, which Mr. Hamster believes isn't really "tin" at all, but is either steel or some other iron alloy. There might be some formation of iron oxide where the water evaporates, this could also be assisted by the heat as well. He thinks this is highly likely.

    Hard to say exactly. Anything else would be a guess short of using GC/MS equipment to analyze the sample.

    The reason why Teflon is used in chemical environments for gasket seals and other items is due to its being inert and non-reactive. The same goes for glass. If one wants to make sure of the quality and purity of any chemical reaction, or process, they will strive to use containers which are completely non-reactive or inert.

    It doesn't pay to take short-cuts in the lab or in the kitchen. Using the right tools for the job will pay off at the end of the day. A hamster, chinchilla or a cat would be wise to use the best tools possible, and non-reactive containers for their experiments.

    Be well...
     
  19. ratatata

    ratatata Silver Member

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    thank you for the response, mr hamster

    my cat used white coffee filters. my cat does need to get higher quality isopropyl but he hasn't been able to get to a store in a week and his nose has been very clogged from all the binders from his focalin so he figured he'd try to just make do, its always difficult for him to find higher % ipa; they don't carry it most places around him, and nowhere in walking distance, unfortunately

    my cat didn't even consider the water content of the ipa he used, that definitely let some binders through. he doesn't think it ever got hot enough to caramelize any sugars but he supposes its possible.

    my cat realized after the second try at extraction that the metal in the altoids container could have reacted with the alcohol and feels like an idiot; he just figured it wouldn't react in any way at first, he didn't exactly think it through. he was in a bit of a rush, so to say

    he also realized afterwards that he probably even ended up shaving some metal off in the process of scraping the crystals; he had a small amount left, perhaps a bump, and he ran a magnet over it. sure enough, it started jiggling around and a few fragments attached to the magnet. ouch! my cat didn't notice anything but he hopes that the insufflation of…. tiny metal shards and anything possibly created by a reaction between his ipa and the metal isn't dangerous. aaah!

    my cat needs to get some glass, he knows, he just broke his glass pan a few weeks agoand hasn't been able to shop for a new one :(


    my cat very much appreciates the answer; he usually does adhere exactly to directions involving any type of extraction/anything vaguely related to drug chemistry; time was of the essence, he supposes, and he acted a bit hastily

    he'll look into getting some teflon or glass containers after he gets his car back in working order, and hopefully his end result will be better. my cat isn't usually one to "freestyle" anything relating to drug chemistry, but he kinda dropped the ball on this one


    thank you!
     
  20. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    To anyone who has tried this:

    Is there a noticeable difference in the level of euphoria due to faster and wider absorbtion?Would it be worth it do do effect-wise?

    Robo