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    PLEASE HELP

Most effective way of taking Adderall?

Discussion in 'Adderall' started by izzy31, Jan 2, 2007.

  1. izzy31

    izzy31 Newbie

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    In your opinion, what's the most effective way to take adderall? (STRICTLY adderall)


    which one gives the greatest, highest effects and an example of the duration?
     
  2. blinkKDX

    blinkKDX Newbie

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    through the nose...I has never done it so can not give info on duration.

    if swim were swiy,he would take 20-30mg up the nose, and then take whatever amount You wants to orally.

    that way You gets the quick high and prolongs it with what's in his stomach.



    there could be a better way?
     
  3. Bajeda

    Bajeda Super Moderator Platinum Member & Advisor Supporter

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    Rectally, of course, will give the highest absorption efficiency and work in short time. For many people this isn't an option however, for various reasons.

    Assuming you are talking about IR adderall, just popping it in your mouth and swallowing on a fairly empty stomach is probaby the most effective way you can find. Drop the pill in a glass of grapefruit juice and drink it, and you may find that works even better thanks to grapefruit's magic properties and the adderall being dissolved already.


    Snorting will hit you fast but won't be nearly as efficient as the other methods, plus it messes up your nose. I really wouldn't recommend this method.
     
  4. sweatloaf13

    sweatloaf13 Silver Member

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    Take a teaspoon or two of baking soda an hr before eating addies to potentiate effects and extend length of effects(<
     
  5. keev

    keev Newbie

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    hmmm... does that baking soda method really work?
     
  6. sweatloaf13

    sweatloaf13 Silver Member

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    Yes it does...look up amphetamines in yr Dr.s PDR or on the information slip that comes w/your script.
     
  7. soer

    soer Silver Member

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    rectal administration is mentioned above as a good way to administer adderall... how would one go about doing this? do they just shove the pill up one's butt? or do they hafta do something else?

    also, its recommended to eat 1-2 tsp baking soda 1 hr before eating the pills.. why does this work?

    thank you in advance for all thoughtful responses.
     
  8. peterarlei

    peterarlei Newbie

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    As for plugging ie. rectal administration yep just shove it up ya butt, peeling off plastic coating helps speed up absorbsion though :)

    As for baking soda:
    The absorption & effects of Amphetamines are also dependent on the ph of the stomach & the urine. An alkaline agent such as Baking Soda (dissolved in water) increases the absorption of amphetamines in the stomach, and baking soda in higher doses makes the urine alkaline, greatly slowing the elimination & thus prolonging the duration & effects of amphetamines (although taking baking soda for this effect is supposed to be pretty bad for your health- Your body constantly tries to find a ph equilibrium, in both the stomach & especially in the blood which is neutral in ph except with severe dehydration or serious health problems). Acidic agents/food/drinks such as certain fruit juices decrease the duration & effect of amphetamines (thus it is better to drink water with Adderall/Dexedrine instead of fruit juice or Colas
     
  9. bewilderment

    bewilderment Drug Geek Extraordinaire Platinum Member & Advisor

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    How would one ingest baking soda, wouldn't it be incredibly awful-tasting to just spoon it into one's mouth?
     
  10. Broshious

    Broshious Silver Member

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    Putting the baking soda in 16oz of water doesn't taste too terrible.
     
  11. sweatloaf13

    sweatloaf13 Silver Member

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    lots of burping will follow the baking soda/water drink
     
  12. GForce

    GForce Gold Member

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    I never heard of the baking soda thing, surprisingly. I'm definitely going to look into that because I could definitely use it. As far as insuffulating goes, I find it obviously hits very quickly, but he doesn't find it particularly strong or long lasting. If he insuffulates say 15mg, it would probably be stronger than ingesting 15mg, but it would lose its effect within an hour. If using adderall for its intended purpose (or for something non recreational like studying) I believe oral consumption is the best route because it was obviously dosed in an effective oral amount. If You is looking to conserve due to a lot of studying and not a lot of adderall, insuffulating is a good way to do a little (say 5mg) and stay alert and focused for around 2 hours.
     
  13. Forthesevenlakes

    Forthesevenlakes Platinum Member

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    The most efficient way to do this would probably be to grind the pill or pellets into a fine powder, and dissolve in water. Then squirt the resulting solution into the rectum with an oral syringe. Just shoving a pill up the butt would probably work too, but wouldn't be nearly as effective.
     
  14. MorganNY

    MorganNY Newbie

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    While not as imaginative as squirting it up one's butt, I've heard it said that crushing the XR pellets in a shot glass with the back of a screwdriver is very efficient. Taking said fine powder and placing it under one's tongue might be a reasonably fast means of introducing it into the bloodstream. (opinions?)
    Another question might be: what if one stirred the powder into some vodka? would it absorb under the tongue faster, more efficiently? Is the whole under the tongue thing a myth?
     
  15. Yoyoj

    Yoyoj Newbie

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    An great alternative to baking soda may be "Ume-Tablets". Sold in natural food stores they are an extract of Ume-Plums the most alkaline food on earth. For that matter wouldn't tums work as well?
     
  16. MorganNY

    MorganNY Newbie

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    Would one be wrong to think that any OTC acid reducer, Zantac, Tagamet etc. would have the same effect? Assuming reducing stomach acidity is the goal?
     
  17. oxalot

    oxalot Newbie

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    SWIM heard a speech by a Dr. recently explaining the use of antacids that may shed light on this matter. We think that taking antacids (same as baking soda) reduces acid in the stomach to relieve the pain of heartburn. While this assumption makes a lot sense the actual process isn the stomach is when we have heartburn we are suffering from a lack of the digestive acids needed for the amount of food ingested. A good test is when you have an onset of acid reflux, heartburn, etc. instead of taking an antacid you take a teaspoon or 2 of vinegar. This results in raisn=ing the acidity of the stomach and thus reduces or eliminates the pain completely. So what does this mean as far as antacids go. The antacid in dissolved into the stomach giving it an immediate rise in alkalinity. The natural response of the stomach is to do what the vinegar would do. Raise the acid level by flooding the stomach with a high dose of acid to aid in digestion. So essentialy when one takes an antacid it causes the body to raise the acidity to achieve the original goal of digestion through proper amounts of digestive acid. This is why drinking grapefriut juice and taking tagamet before taking certain chemicals can effectivly raise the effecacy of the drug. This has been discussed many times here trying to save money and product by raising bioavailability when things rae taken P.O. I don't know of any way of making a quantitative analysis of amounts of these precursor items needed to make the best "high" but I would think that 8oz. glass of Grapefruit juice and 200-400mg of tagamet taken 1/2 hour before might do the trick. Any help on that matter is quite welcome. Of course this is all conjecture on SWIM's part having heard the Dr. and assessing his knowledge with what little I know about chemical reactions and drugs. I hope this sheds a little light on this matter that comes up so often on this board though.
     
  18. Broshious

    Broshious Silver Member

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    Isn't grapefruit juice effective because it interferes with the cytochrome P-450 3A4 enzyme?
     
    Last edited by a moderator: Apr 30, 2017
  19. pharmer2011

    pharmer2011 Newbie

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    Actually grapefruit juice shouldn't have a synergistic effect on Adderall; Adderall is processed by the enzyme CYP2D6 (one of the CYP450s), and sodium bicarbonate is an inhibitor of these enzymes so the drug remains in the blood stream in its active form for a longer period of time, since less receptors are available to metabolize it to a form that is inactive and can be excreted via the urine.

    Grapefruit juice effects the enzyme CYP3A4 which is responsible for the metabolism of many drugs (Lipitor, simvastatin, etc.) but in this case since adderall is a weak acid, if you take it with something acidic, its going to increase its excretion (like dissolves like). By adding baking soda to the GI tract before taking Adderall orally, you're creating a more alkaline environment so the drug will be metabolized slower, and thus again will stick around active for a longer period of time.

    However oral doses will always have the problem of being metabolized greatly via the liver to inactive forms, thus is the least efficient delivery method if you're looking to get a high off the drug in my opinion. To insufflate nasallty does allow some drug to be absorbed by the nasal mucosa and avoid that liver metabolism, but as you know if you've done this much... that "drip" ends up in your stomach and is metabolized that way.

    Rectally probably is most effective but least desirable/feasible for most. In the past i've found that consuming a saturated sodium bicarbonate solution, then going to work crushing up some pills, bumping a couple little lines, then swallowing the crushed powder works very efficiently.

    Another final option is to crush tablets and place the powder under your tongue and allow it to absorb their. Alternatively, tablets can be placed between your gums and cheek, and will be absorbed bucally, which also avoids that annoying inactivation that the liver causes when the drug is taken orally, so the drug gets into the blood stream in an active form at a higher concentration.

    Speaking by a combo of education and experience, so partially opinion. I had always though nasal route was the best way to go, but recent research seems to be indicating that there is some inactivation similar to the liver going on when drugs are inhaled... :crazy

    pharmer2011 added 47 Minutes and 1 Seconds later...

    I would stick with the quick release, basic, chewable, chalky, Tums, Rolaids, type of acid reducers. Zantac takes longer to take effect on the pH of the stomach and its mechanism of action is different than normal antacids. As for Tagamet (cimetidine), although it doesn't have any listed interaction with amphetamines, it has a HUGE amount of interactions with other drugs (which do include regular antacids like Tums, Maalox) so I always recommend staying away from that if possible.

    If you take Zantac regularly already... then your stomach is probably all set up at a higher pH. But otherwise, I'd suggest saving your money and choking down the chalky tums-type antacids. Its your safest bet, cheapest, and they will work the quicker than the Zantac because you generally chew them and they dissolve rapidly in the stomach, changing the pH quicker, so you don't have to wait forever after taking them to take the adderall.

    Or just use baking soda.... I choke down seriously salty solutions since i don't like taking traditional antacids, and that seems to do the job, especially as far as duration of action, not as much so as for intensity.

    I'm still seeking out shorter duration, higher intensity methods that don't involve shoving solutions up my ass, but, have sadly yet to find anything. In the mean time, as I mentioned just before, I dissolve them in my mouth under the tongue or between the gum and cheek for the most part.... according to some data up to 85% of amphetamines are inactivated by the liver and GI wall following swallowing the drug, while absorption through the mucosa in the mouth via buccal administration, numbers range from 40-60% of the drug still active once absorbed.
     
    Last edited: Aug 9, 2009
  20. Muska

    Muska Newbie

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    grape juice is full of vitamin C which takes away from swiy

    Muska added 6 Minutes and 28 Seconds later...

    how does one edit? - Anyways I will either break up and just drop, or snort, I used to crush up xrs and take it with a shot of milk, swim loves milk and its great to drink as it keeps your stomach more base. ie less acidic.
     
    Last edited: Aug 28, 2009