Before I start, let me list some threads that seem to bear some relevance to this question: https://drugs-forum.com/threads/dru...-hypnosis-trance-induction.72054/#post-500779 https://drugs-forum.com/threads/met...-mind-that-are-not-drugs.196394/#post-1196454 https://drugs-forum.com/threads/replicating-heroin-high-with-hypnosis.138900/#post-1384589 https://drugs-forum.com/threads/hypnosis-to-get-high.35447/page-2#post-1345528 https://drugs-forum.com/threads/take-a-vote-pick-your-favourite-dissociative.290941/#post-1778558 https://drugs-forum.com/threads/the-power-of-suggestion.76149/#post-527900 https://drugs-forum.com/threads/scopolamine.72640/page-2#post-1806478 https://drugs-forum.com/threads/similarities-between-diphenhydramine-trips.329997/#post-1990380 My question is as much to do with my scepticism about the effects of narcotics as it is about the effects of hypnosis. I've read a bit about how the brain works, how memory is encoded and retrieved, what neurotransmitters do, and what effects different drugs are reported to have with respect to the above. Something I read about how the memory of dreams works intrigued me, because I had previously thought that acetylcholine was largely responsible for the encoding of memories from working memory to short-term memory to being consolidated into long-term memory; but apparently dopamine and aminergics play a role too. I'm not talking about how dopamine tunes long-term memory, but how the memory of dreams involves chemicals other than acetylcholine. So we read that anticholinergic antimuscarinics impair memory, but not entirely, which is probably why people are able to write reports of some parts of their experiences. So that prompts me to wonder whether some memory still works when acetylcholine is inhibited, because other "stuff" is involved in that memory-making, and perhaps it's certain criteria of memory that is not so impaired because acetylcholine is not involved in every type or aspect of memory. So, i'm not fully convinced about hypnosis, whilst there are published papers and loads of anecdotal reports, for it to be a real thing, there must be some specific mechanism going on. When people say "hypnosis", i suspect they usually mean the implanting of instructions or triggers. i wonder how post-hypnotic suggestions are encoded, and whether any drugs help with that because of how they work. One or two threads suggest possible candidates like LSD, cannabis, scopolamine etc.. but i'm not yet convinced whether someone on these would be hypnotisable and whether anny suggestions would stick. It's all very well being super-relaxed or super-suggestible, but if you can't remember anything, does is still work?! More to the point, why does it work (or not work)? Do particular things allow or inhibit suggestions to linger? When i read about how hypnotic induction isn't needed, and it's just about relaxation and imagination, i'm wondering whether drugs would either help or hinder retaining suggestions. I'm guessing there are ethical and legal (or insurance) reasons why scientific studies aren't done on this, so perhaps we'll only have anecdotal evidence to have any clues? This, of course assumes that real hypnosis is actually a thing, more than just deep relaxation and imagination or CBT. It might even be amusing to make a table of narcotics, and describe what might probably happen if a person on each of the drugs was hypnotised.