Naxolone is a µ-opioid antagonist used in the treatment of opiate overdoses. It also has the side effect of artificially inducing withdrawals(It can actually induce them in people who have never taken opiates, by antagonizing endorphins). So, my theory is relatively simple. Induce withdrawals in an opiate addict via treatment with naxolone and sedate them for a couple of days until the body becomes "re-adjusted" to the normalized mu-activity. Am I totally tripping right now or would this work wonders? EDIT: Heh, nvm. Looks like most prescription opiate addiction treatments are brand-name versions of naxolone/naltrexone. But still, the user shouldn't actually have to undergo the withdrawals. They could be sedated with benzos and the opiate sensitivity would still re-adjust just fine.