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Oral use - Need to increase Tramadol effect. Please help!

Discussion in 'Tramadol' started by Reskay, Sep 28, 2009.

  1. Reskay

    Reskay

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    SWIM cannot get the desired effect from tramadol, SWIM has 8 x 50mg left SWIM knows he cannot get the effect anymore. SWIM has tried Grape Juice to no avail.

    What can SWIM mix with to get the effect he used to?

    Tramadol + Ibruprofen?

    Tramadol + Co-dydramol?
     
  2. Herbal Healer 019

    Herbal Healer 019 Silver Member

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    It's not grape juice it's grapefruit juice my man:thumbsup:.

    Other than that, the above is true. Also note that there is a ceiling effect for tramadol & I'm pretty sure 400mg is in excess of that ceiling effect.
     
  3. Villan

    Villan Newbie

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    yop, dont take more than 400mg a day. tramadol sucks donkey dick.
     
  4. Sassy88

    Sassy88 Silver Member

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    My pet ferret thinks mixing 2 acetaminophen and 25-50 mg. of diphenhydramine with her usual tramadol dose seems to enhance the effect- though it's nothing earth-shattering. Just more pronounced. And there is nothing overly dangerous with mixing low dosages of tramadol with low dosages of the other 2 ( to her knowledge ).
     
  5. Ale

    Ale

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    Swim heard there was some positive synergy between Tramadol Hydrochloride and low doses of DXM.
     
  6. zaxthing

    zaxthing Newbie

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    Phenergan or vistaril might help--they potentiate conventional narcotics that work in the same receptors in the brain...
     
  7. veritas.socal

    veritas.socal Silver Member

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    sassy88 mentioned dyphenhydramine, which swim finds will potentiate most opiates and dxm(which is a super long distant cousin to morphine, swim heard, and swim knew a dude who failed urinalysis for opiates, 30hrs after large dxm dose{dxm only}) it will potentiate trams. swim finds 100mg to be a typical potentiation dose!
    swim also has found that gabapentin(neurontin) 600-1200mg taken w the trams will potentiate. cannabis? swim definitely has taken 3/4g(750mg,or 15 of the 50's) and been higher than 400 mg. but sicker to the point where more than two hits from a roll up cigarette would make swim puke
     
  8. dugg

    dugg Silver Member

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    Cyclizine is the only potentiator that swim found to work. Be aware swim found tramadol wd the worst , far nastier than morphine,codeine or fentanly wd.
     
  9. CCApollo

    CCApollo Silver Member

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    Taking DXM, even at the therapeutic dose, with Tramadol is a bad idea. This combination can cause Seretonin Syndrome due to Tramadol's effects of the level of Seretonin present. This is what makes is different from traditional opiates, as it has anti-depressant aspects. Some believe that this is also why the withdrawal is more severe, despite the fact that it is a weaker opiate in comparison to the more traditional perscriptions such as Hydrocodone, Oxycodone, ect... In summary, be very careful, as SWIY always should, when combining any sort of medication, OTC or not.

    SWIM has read recently that Saint John's Wort may be a suitable drug for potentiatint Tramadol, but SWIM does not have first hand evidence of this. This may not be safe either , as it also effects Seretonin levels, albeit at a much lower level than DXM. SWIM would suggest doing more research into this before trying it, in the interest of saftey.

    Be safe, and utilize the great resource that is Drugs Forum, as well as many other credible resources on the Internet. Check your sources, do the research, and stay safe!
     
  10. Jasim

    Jasim Gold Member

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    St. John's Wort affects serotonin levels to a much greater degree than dextromethorphan does. It's contradictory to say that DXM with tramadol may be unsafe, but to recommend St. John's Wort.

    Serotonin syndrome is actually not that easy to get to. When we discuss serotonin syndrome it typically involves potent serotonergic pharmaceuticals that are specifically geared towards increasing levels of serotonin or the monoamines.

    Combining pharmaceutical MAOI's with serotonergic agents is the number one cause of serotonin syndrome. Most herbal MAOI's are reversible and not potent enough to contribute to serotonin syndrome under normal circumstances (unless combined with a pharmaceutical SSRI or MAOI).

    Tramadol itself does not increase serotonin levels relatively that much. I think combining tramadol with DXM or St. John's Wort should not be a concern for serotonin syndrome. My pet turtle Clover has done both and has reported to ill-effects.

    What is of MUCH greater concern is the fact that tramadol lowers the seizure threshold.

    Seizures are a very real danger of tramadol use, especially when combined with any agents that increase neurotransmitter levels or that have excitatory CNS action. Tramadol should NOT be combined with other drugs that decrease seizure threshold or in subjects who have a history of seizures or have recently stopped taking a drug that raised seizure threshold (benzodiazepines, gabapentin, chronic alcohol use, etc.).

    To be clear, when I say "lowers or reduces seizure threshold" I mean they make it easier to have seizures and likewise to "raise or increase seizure threshold" makes it less likely to have seizures.
     
  11. antialias

    antialias Silver Member

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    IF anyone is planning on taking a very large dose of tramadol, combine it with a small dose of a muscle-relaxant/anti-epilepticum like clonazepam (but keep an eye on swiys breathing since clona is a benzo) to try to avoid cramps/seizures.

    To swim, tramadol is a typical drug that is not really fun when taken alone.. first, some freshly squeezed grapefrugit. Then it should be mixed with first and foremost cannabis (most important) and then a beer or two but not more and if swiy is not too buzzed slip a little clonazepam och valium in the mix but as said before..watch swiys breathing and take this mix with a friend who can watch you if possible.. mixing opioids and gaba's can be dangerous but if swiy don't overdo it will perobably fine. Just don't go to sleep until swiy feel most of the buzz has worn off..
     
  12. zaxthing

    zaxthing Newbie

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    My pet tiger has had some luck with Tramadol+Phenergan to increase effect.
     
  13. zerozerohero

    zerozerohero Titanium Member

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    If one's looking for pain-relieving effects, combining tramadolw ith Ibuprofene is very effective, especially if 600mg Ibuprofen doses are available (mostly soluble form otherwise get 400mg pills that can be cut in halves).
    For intense back pains, my blow-up-dick-nickson uses 50 mg tramadol + 600mg ibuprofen 4 times a day, ideally every 8 hours - instead of 50mg, 100mg may be used if really needed.

    It is strongly advised to:
    - ask the doctor for advice.
    - ask the doctor for a prescription of Omeprazole, since ibuprofen gets gastro-toxic at 2400mg/day and one might develop stomach problems.
    - keep each intake at least 6 hours apart.

    My blow-up-dick-nixon gets excellent results with this combo, even in cases of very severe tooth pain (aka failed root-canal...), where tramadol alone is pretty useless and ibuprofen does not do the trick by itself either. The main use of this combo is for back pains that nothing else relieves anymore (and BUDN does not want to step up to stronger opiates anymore) and results are quite impressive in that guy's case.
     
  14. icekrm

    icekrm

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    Since I crossed tramadol limitsat 400mg,Ive done before that for 2 month binge codein.
    Only crapppy "legal" local things to get passed through the time.
    Codeine withdrawal now

    PS: Since you could start a modafinil short treatment, You should see your tramdol tolerance imbalance.
     
  15. Boagie

    Boagie

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    Either go strung out m8 or try a stronger opiate
     
  16. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    Actually, Robo was just about to post a new thread on his findings on how to potentiate (or rather be able to take more) tramadol, and has had results equal to 300mg of codeine, if not even superior.

    Robo will put ti in a nutshell here before making a thread:

    The reason why tramadol cannot be taken in high doses is because of the risk of seizures.Now if you already have a seizure disorder, this is definitly something you should not do, and Robo is not recomending anyone to do it.It is simply the report of an experiment gone fantastically well.

    Basically, swim thought that since you couldn't take more than 400mg without risking a seizure, he should take a drug along with it that prevents seizures while potentiating it's effects, not only being able to take a much larger anmount of the drug, but also take away that speedines that Robo hates so much when taking tramadol.

    Anyway, basically swim has been experimenting with clonazepam as a way to prevent seizures when taking variying amounts of tramadol.He did this little by little, increasing the dosage each time and here's the latest result:

    Swim took:

    T-00 1mg clonazepam

    T-10min.1.3g of tramadol

    T-40min. 1mg clonazepam

    T1:45 2mg clonazepam

    It's been exactly 4 hours and 22 minutes since he took the inicial dose and has had no seizures or side effects of any kind so far.He is, however, enjoying an opiate high, IDENTICAL to that of 300mg-400mg of codeine (And swim has been using codeine for 3 years now, on a weekly basis).

    Notes of importance:

    -Robo chose clonazepam because it is a long-acting benzodiazepine, one of the longest-acting ones.

    -Robo already has a mild tolerance to clonazepam at this point, hence the large doses.

    -This should NOT be done by people with a history of seizures, or even tramadol-related seizures in the past.

    -The results of this experiment were very successful, but Robo in no way recommends this to anyone.If you do this, it's at your own risk.



    And lastly, everyone's body reacts differently to different drugs so:

    -Know your substance
    -Know your body
    -Know your source

    Robo

    RoboCodeine7610 added 4 Minutes and 30 Seconds later...

    Oh, and as a side note, before you guys ask:

    -Respiratory depression has not been an issue for Robo, at all.Clonazepam causes less respiratory depression than other benzodiazepines btw, so if anyone does this with a different benzo, beware of this risk.
     
    Last edited: Mar 1, 2011
  17. zerozerohero

    zerozerohero Titanium Member

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    My Blow-Up-Dick-Nixon-Doll (a.k.a. BUDND) wishes to provide the following advice regarding the above post by robo: what might work for robo with clonazepam, might not work for others, or might work with other benzos.
    BUDND has indeed mixed clonazepam with tramadol without further problems, but without pushing tramadol dosage that far.
    BUDND had a horrendous surprise mixing tramadol with another benzo called Librium (Chlordiazepoxide) : 200 mg Tramadol, with their usual effect, were very heavily potentiated by just 5mg librium. It wasn't really potentiation, as the pain-relieving effects of tramadol were not enhnced, but BUDND was just simply completely shot out of his underpants with this combo, whereas mixing the same amont of tramadol with even 2mg of clonazepam would never ever produce such an effect on him.
    BUDND wants to advise other users to be very cautious when mixing tramadol and benzos as they are both strong CNS depressants, and everyone should know by now that mixing CNS depresants has cost many lives and many rock-stars to the world already ;)
     
  18. Laudaphun

    Laudaphun Gold Member

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    That is quite interesting that 5mg chlordiazepoxide somehow caused such a strong effect when combined with 400mg tramadol, especially when the marmoset who ingested these drugs also experimented and compared the results with 2mg clonazepam.

    Firstly, clonazepam in and of itself is not the best substance to enhance the effects of tramadol, however it is a great safety precaution as it is used as an anti-seizure medication. Clonazepam is sometimes prescribed along with tramadol when first initiating a patient to tramadol treatment for the sole reason of the risk of seizures with tramadol use.

    SWIM is really irritated as she had a stash of chlordiazepoxide 25mg and 10mg buried in the back yard (not literally) for emergency last resort solution to benzo withdrawl should that ever occur. However they seem to have disappearred and now there is no reason for SWIM to be able to obtain chlordiazepoxide again. SWIM's marmoset would have really liked to experiment with SWIYs results.

    Diazepam is very closely related to chlordiazepoxide and many other benzos that have active metabolites are more or less similar in that the majority seem to be metabolized to nordiazepam. This holds true for quite a few of the 1,4-benzodiazepines and their similar active metabolites. The triazolo-benzodiazepines such as alprazolam, midazolam, ect typically do not have active metabolites. So it may be worth "very carefully given the previous posters experience" investigating other 1,4-benzodiazepines that are closely related to diazepam. While chlordiazepoxide obviously is a bit of an oddball with its atypical structure, its active metabolites are nordazepam (desmethyldiazepam), temazepam, oxazepam, and some others... So while it is significantly different structurally than diazepam, it shares most of the same active metabolites as diazepam is metabolized via hydroxylation to temazepam which is metabolized to oxazepaam via N-demethylation. Diazepam is also metabolized into nordazepam (desmethyldiazepam) via N-demethylation. So the question SWIM is wondering is if it is the active metabolites which are responsible for such a pronounced effect at such a low dose or the chlordiazepoxide which is active for around 24 hours before it is metabolized to the above mentioned metabolites. Just a word of caution, SWIM would not recommend these combinations but inevitably people will, SWIM would recommend a sitter until sure why such a seemingly tiny dose of chlordiazepoxide (5mg) would have such an effect. It may be something totally different, some other compound in your body... lots of variables.

    clonazepam is not metabolized into any active metabolites that SWIM's marmoset is aware of.

    DXM is not a potentiator in the true sense as it is actually an NMDA inhibitor which interferes with the cell memory process, which in turn causes prevents tolerance from occuring when taken concurrently with most addictive substances (morphine was the particular drug SWIM is most familiar with as it was used in the study where SWIM first learned of this). It not only prevents tolerance (not completely, but significantly), it also reduces opiod tolerance when take by itself. Now since tramadol is not exactly a traditional opiate SWIM does not know for sure if it will act similarly to tramadol as with morphine.

    So far, the most useful combination SWIM has discovered is tramadol's ability to effectively kill pain while buprenorphine is in the system which blocks traditional opiods.

    SWIM has heard of people having good success with tramadol + carisprodol (this is supposedly similar albiet weaker than the more well known hydrocodone/carisprodol combo which can be quite dangerous)

    Also, for pain relief SWIM's marmost routinely uses 50-100mg tramadol + 400-800mg ibuprofen... But you really need to watch the intake of both substances as the max recommended dose of ibuprofen is 3200mg/day so if necessary and no other options, 100mg tramadol + 800mg ibuprofen could be taken 4 times per day. That is something you really need to discuss with your doctor though before reaching that thresholds.

    Everything SWIM has said is just theoretical and SWIM does not recommend trying any of these combinations without consulting your doctor first. Please BE SAFE!!!
     
  19. wrek1

    wrek1 Silver Member

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    Thats low, what an insult to the question which is asked? people ask for help here and you are just giving them shit.... stick a pole up ur ass and get some common sense to help others or dont answer the question at all
     
  20. Snipez

    Snipez Newbie

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    Would one feel more analgesic effect from taking all of their tramadol dose at once or taking half of it first and half of it an hour later? I've read some places that already having tramadol in one's system increases the bioavailability of any more tramadol added but have never seen any citations of clinical studies or anything to prove that so maybe it's just a rumor that started from people's placebo effect. Does anyone have any ideas about that or could cite any reliable sources?