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Experiences - **NEW** F-Phenibut Experience

Discussion in 'Nootropics' started by Bro Smurf66, Mar 18, 2016.

  1. Bro Smurf66

    Bro Smurf66 Silver Member

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    I ordered some F-Phenibut the first day it came out (from the company I usually order from). It is said to be around 5-10x more potent than Phenibut HCL. I tested a 200mg dose of F-Phenibut, and it felt like 2-3 grams of Phenibut HCL. The onset started to come on at the 1 hour mark, and gradually 'built up' until it peaked at 3-4 hours after dosing. The total duration was about 8-9 hours. It seemed like it was less stimulating and more sedating than Phenibut HCL, but I'm 95% sure it was due to the potency: 200mg F-Phenibut felt like 2-3 grams Phenibut HCL, while I usually take 1.2 grams Phenibut HCL, so this was probably the reason why I was more sedated.

    Today (2nd time testing) I tried 130 mg F-Phenibut. It felt like my normal 1.2 gram dose of Phenibut HCL, although it didn't hit me as fast as the HCL, which usually gives me an energy boost and makes me super talkative. It sort of reminds me of a cross between Phenibut HCL and F.A.A. in terms of duration and intensity.

    Not many people have tested this compound yet, so I thought I'd let our DF family know about it! Feel free to ask any questions. It might take me a few days to respond, so please be patient. Thanks!
     
  2. Adas

    Adas Silver Member

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    Fluorinated phenibut? That would look similar to Baclofen. Baclofen is a GABA-B agonist, Phenibut is mostly Ca2+ channel blocker. This could explain the difference.
     
  3. Jonathan James Jones

    Jonathan James Jones Newbie

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    I don't know man, I'd say phenibut's got a whole of GABA agonism going on. It sure does feel like it. I know when my GABA system's going - the effects are unmistakable. At least for the first 2 or 3 hours phenibut feels very benzo-ish....at Hour 4 though it shifts course and feels like I'm surging with adrenaline.
     
  4. Bro Smurf66

    Bro Smurf66 Silver Member

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    Yeah Phenibut is definitely a GABA-B agonist, and is also a potent VGCC (Voltage-Gated Calcium Channel) Blocker, similar to Gabapentin and Pregabalin (and Baclofen to some extent).

    Just because Phenibut is a weaker Gaba-B agonist than Baclofen by weight doesn't necessarily mean it's mostly a Ca2+ channel blocker.

    Baclofen is "β-(4-chlorophenyl)-γ-aminobutyric acid", while Phenibut is β-(phenyl)-γ-aminobutyric acid. The only difference in the molecular structure of Baclofen and Phenibut is that Baclofen has a Chlorine tacked on the end of the Phenibut structure.

    F-Phenibut is 'Fluorinated' Phenibut, while Baclofen is like 'Chlorinated' Phenibut.

    @jonjones (nice name haha)-- I wonder if your body realizes that there's above normal levels of GABA in your system after the 4 hour mark and your body releases norepinephrine to counteract it while the GABA wears off, leaving you more stimulated? Just a theory. The human body is always trying to reach homeostasis!
     
  5. Adas

    Adas Silver Member

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    "Subsequent research has found that phenibut also binds to and potently blocks α2δ subunit-containing voltage-gated calcium channels (VGCCs), similarly to gabapentin and pregabalin. Both enantiomers of phenibut show this action with similar efficacy. Moreover, the R-enantiomer possesses five-fold greater affinity for this site relative to the GABAB receptor, while the S-enantiomer does not bind to the GABAB receptor at all. As such, phenibut is likely to have much greater effect on α2δ subunit-containing VGCCs than on the GABAB receptor." - Wikipedia

    Here you have it. The Wikipedia article had been expanded a lot lately.