Please post any information regarding Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester). Noopept is a Piracetam analogue with vastly increased potency (1000x, Ostrovskaya et al., 2002). As with piracetam, it acts as an allosteric AMPAR agonist, while also suppressing Ca2+-gated K+ channels as well as voltage-gated Ca2+ and K+ currents (Solnsteva et al., 1997). It has been shown to have significant neuroprotective properties, as well as memory-enhancement in a number of animals models (Ostrovskaya et al., 1999, 2007, 2008; Pelsman et al., 2003). It also enhances activity of the immune system in both healthy and immune-compromised animals (Kovalenko et al., 2007). It is prescribed in Russia and certain other eastern-european countries, though not in America. It also readily crosse the blood-brain-barrier following oral administration in modest doses, though some people claim it has higher bioavailabilty sublingually and is ineffective orally (I can find no evidence for this, aside from anecdotal reports).