Drug info - Nor-LSD and others what is this?

Discussion in 'LSD' started by nikonikad, Aug 13, 2004.

  1. nikonikad

    nikonikad Gold Member

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    I found of a pharma company this products, are they interesting or not?

    6-Nor-d-lysergic acid N,N-diethylamide (norLSD) (CAS #35779-43-2)

    6-Nor-6-allyl-d-lysergic acid N,N-diethylamide d-tartrate (DALL) [mod edit: better known as AL-LAD]

    6-Nor-6-cyclopropyl-d-lysergic acid N,N-diethylamide d-tartrate (CPL)

    6-Nor-6-ethyl-d-lysergic acid N,N-diethylamide d-tartrate (DETH) [mod edit: better known as ETH-LAD]

    6-Nor-6-propyl-d-lysergic acid N,N-diethylamide d-tartrate [mod edit: better known as PRO-LAD]
     
    Last edited by a moderator: Jul 25, 2012
  2. Pinkavvy

    Pinkavvy Platinum Member & Advisor

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    hmmm.... very interesting. does anybody know about the above chems? are they anything like acid? is it available through research companies? (if so, please post it in the sources forum.)


    especially curious about norLSD ... what's it like?
     
  3. nikonikad

    nikonikad Gold Member

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    Nobody knows something about it, come on guys, it is realy interessting
     
  4. Kemikaru_Tenshu

    Kemikaru_Tenshu Platinum Member

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    Nor-LSD which could also be considered 9,10-didehydro-N,N-diethylergoline-8b-carboxamide (someone correct me if I'm wrong as this is off the top of my head), which would mean that the indole nitrogen is unsubstituted (has an H atom bonded to it instead of the methyl group of LSD).


    6-Nor-6-ethyl-d-lysergic acid N,N-diethylamide is also called ETH-LAD or N-ethyl-nor-LSD which means that the indole nitrogen is substituted with an ethyl group (one more carbon and 2 more hydrogens than the methyl of LSD-25). This compound would be an easy preparation away from Nor-LSD.


    6-Nor-6-allyl-d-lysergic acid N,N-diethylamide d-tartrate (DALL),
    6-Nor-6-cyclopropyl-d-lysergic acid N,N-diethylamide d-tartrate (CPL), and
    6-Nor-6-propyl-d-lysergic acid N,N-diethylamide d-tartarate are all tartaric acid salts of compounds of Nor-LSD substituted in a similar manner to ETH-LAD with allyl, cyclopropyl, and propyl groups respectively.





    ~KT
     
  5. Kemikaru_Tenshu

    Kemikaru_Tenshu Platinum Member

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    I meant the nitrogen at the 6 position is substituted not the indole nitrogen. The indole nitrogen remains unsubstituted as it is in LSD.

    ~KT
     
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  6. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    ETH-LAD from PIHKAL:


    DOSAGE : 40 to 150 micrograms, orally


    DURATION : 8 - 12 hrs


    QUALITATIVE COMMENTS : (with 20 µgs, orally) "This has a very real effect at this level, whereas I have no response at all from LSD at 20 mikes."


    (with 50 µgs, orally) "This is already coming on in fifteen minutes, and is completely developed in another hour. Very few visual changes or distortions but easy eyes-closed imagery. Pretty much out after ten hours; it was a good, repeatable experiment."


    (with 60 µgs, orally) "In about an hour or so, gentle movements of the house plants were noted. The walkway of the painting above the fireplace changed as if the sunny spots were moving ahead. The visual aspects became more LSD-like after a couple more hours, though in a very gentle way. The spider windowpane looked three-dimensional: at first I thought the windows were double-paned, but they were not. Stones, rocks and glass had a magical look to them, but tree bark looked like tree bark. Occasionally, a dark streak (spot) would go through the visual field and a page of a book would move sharply without effort. These aspects were very pleasant to me."


    (with 75 µgs, orally) "I am up to a ++ within the hour and am feeling lazy. It is very diuretic and certainly not anorexic. Have been dieting strenuously for the past 4 days, but could definitely be interested in food. Also a decongestant. Body feels balanced. Thinking easy. Concepts easy to follow through. Mind and feelings together as should be. Definitely a plus two, no further. I wonder if it would be possible, at any level, to attain that blurring of boundaries that is the plus three at its best? My mind was at all times capable of realistic and down-to-earth thought, this is not a material that will allow you to float two inches off of the floor."


    (with 100 µgs, orally) "It sort of sneaks up on you. Certainly not the push of LSD and, sadly, not the sparkle either. Possible time slowing. Easy sleep and no price to pay the next day."


    (with 150 µgs, orally) "Extraordinary experience, none of the demands of LSD, just a completely together trip. There were hints of tummy discomfort and some chills early in the trial, but they were trivial and quickly passed. Fine music, and fine sex."


    EXTENSIONS AND COMMENTARY : What a remarkable compound. It is a little more potent than LSD, but much less aggressive in the nature of its action. There appears to be little if any of the push, the taking control nature, of LSD and a greatly modified degree of visual distortion. The warmth and humor appears to be there, but all seems more allowing rather than demanding.


    I suspect that this material is rather unstable in solution, even as the tartrate in dilute saline, although I cannot guess why that should be. A few months in the dark, at zero degrees and in the absence of air, led to a very real drop in potency, measured by a control assay of a freshly made solution of the same nominal concentration.


    What a difference a single atom makes, an ethyl rather than a methyl group at the ring-D nitrogen atom. The absence of any group there (a hydrogen atom rather than the methyl group of LSD or the ethyl group of ETH-LAD) is nor-LSD, the synthetic intermediate mentioned in the preparation recipe above. It has no activity at all even at a half a milligram. The allyl group at this location gives AL-LAD and the propyl group is PRO-LAD, and both of these are active and have their own individual entries.
     
  7. Kemikaru_Tenshu

    Kemikaru_Tenshu Platinum Member

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    <BLOCKQUOTE> Originally posted by Alfa on 03 September 2004
    <HR>
    The allyl group at this location gives AL-LAD and the propyl group is PRO-LAD, and both of these are active and have their own individual entries.
    <HR>
    </BLOCKQUOTE>


    So two of the others on the list are also active. Shulgin says about the series in Tihkal:


    "Most of them [the LAD series] proved to be less potent than LSD, and considerably less dramatic."


    But I gather from the reports that they would be worth one's time to investigate.





    ~KT
     
  8. Kemikaru_Tenshu

    Kemikaru_Tenshu Platinum Member

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    <BLOCKQUOTE> Originally posted by Alfa on 03 September 2004
    <HR>



    The absence of any group there (a hydrogen atom rather than the methyl group of LSD or the ethyl group of ETH-LAD) is nor-LSD, the synthetic intermediate mentioned in the preparation recipe above. It has no activity at all even at a half a milligram.
    <HR>
    </BLOCKQUOTE>


    So nor-LSD has no activity. This is very interesting from a pharmacological standpoint.





    ~KT