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Dose - Oxycodone LD50

Discussion in 'Oxycodone' started by jWilson3585, Jan 26, 2011.

  1. jWilson3585

    jWilson3585 Silver Member

    Reputation Points:
    Nov 3, 2010
    Male from U.S.A.
    My dog can't seem to find the LD50 for oxycodone anywhere, he looked at the Wiki on this site and also on erowid.org, google seems to be useless too. Please help him out.
  2. Piglet

    Piglet Titanium Member

    Reputation Points:
    May 28, 2005
    46 y/o Male from U.K.
    LD50 is something used for testing in lab animals - it's the TI (thereputic index) that is used for prescribed drugs. It's not the fatal dose, but when it becomes toxic in some way. Maybe you could post a list with the TI of all the opioids?

  3. PsychoActivist

    PsychoActivist Palladium Member

    Reputation Points:
    Oct 28, 2008
    36 y/o Male from U.S.A.
    Interesting... It's not published anywhere. I just looked in both - my PDA & Merck Index - and neither one had an LD50 for it. Let me see if I can't gather some statistics on deaths that have occured from toxic doses both with & without alcohol or other CNS depressants and I'll post back.
  4. LostControl

    LostControl Silver Member

    Reputation Points:
    Mar 10, 2010
    Female from Canada
    As people become more tolerant to opiates the more they take, long term users can take very large doses of drugs and have very little effect, whereas the same dosage would cause death in an opioid-naive patient. For example, a kitty I know takes over 1000 mg of oxycontin daily. That would knock out - and possibly kill - the average kitty. For that reason, TIs and LD50s are likely not available. LD50s are not only used for lab animals - they are discussed as well when talking about people - for example, you'll often read in reports that there is only a very narrow window between the LD50 and TI for acetaminophen (which, in non-technical speak means that there is a very small window between the dosage of acetaminophen that gives pain relief (the therapeutic index - TI) and the dosage that kills 50% of people (the lethal dose for 50% of people = LD50). That's why there are so many warnings about Tylenol (acetaminophen) - because you can take 2 extra strength tablets 4x daily for pain relief, but double that and you're risking liver failure.
  5. Synaps

    Synaps Silver Member

    Reputation Points:
    Jul 27, 2010
    Male from norway
    It would be unsafe to inform about the LD50 of frequently abused opioids because ill-informed people would use the LD50 to dose themselves, and therefore overdose because they did not really know what LD50 was.

    Tolerance and current pain level (in other words, individual body chemistry) also plays a huge part in it.