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Combinations - Oxycodone with Codeine?

Discussion in 'Oxycodone' started by Davidazors, Mar 12, 2012.

  1. Davidazors

    Davidazors Newbie

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    Hey all!

    SWIM has little experience with opiates and no experience with combining them. SWIM has only ever taken a 35mg dose in the form of 5/325 oxy pills 3 separate times and has found the experience to be quite enjoyable, but nothing spectacular. Tonight he only has access to 25mg of oxy and is worried it will not be nearly as enjoyable. SWIM only comes across this stuff occasionally so he wants to make the most out of the experience! SWIM also happens to have two T3's on hand and is wondering if 25mg of oxy and 60mg codeine would be enjoyable and safe? SWIM knows that 25mg is pushing it for an opiate naive person, but SWIM is a big boy (215lbs) and can clearly handle it from his previous experience. He also knows codeine is a very week opiate, but would 60mg of it on top of the 25mg oxy be enough to push him into a dangerous place? He knows the strength and appropriate dose of each but has no Idea how they will work when combined.

    Also is 2000mg apap dangerous in one dose? SWIM has done it before without falling into acute kidney failure luckily, but was thinking of doing a CWE to give his kidneys a break. If he did a CWE would that make the drugs more potent/dangerous due to the fact they may enter the blood stream faster?

    Any help from the more knowledgeable would be much appreciated!

    Thanks
     
  2. baZING

    baZING

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    First of all, taking any dose of APAP over 1000mg is unwise. 2,000mg might not send you into acute liver failure (large doses of APAP are more of a concern for your liver than kidneys), but it's really a toxic substance when taken in that amount. Therefore, any time the APAP in your dose amounts to more than 1000mg, you should be performing a CWE. It's really that simple. Doing a CWE on those pills won't really make them any more potent or reach your blood stream any faster. With the oxycodone dissolved in liquid it may kick in a few minutes sooner than still in pill form, but really not that much.

    The obligatory warning here is that mixing CNS depressants is never safe. In all reality, you're better (safer) off taking the 25mg of oxy after performing a CWE and enjoying a lesser buzz.

    If you are determined to mix them, though, I would either not take both of those T3s or not take the full 25mgs of oxycodone. Even though 60mg of codeine is equivalent to only about 6mgs of oxy (when taken orally), given the fact you've never combined these two before, it's probably not wise to take everything you have. The overall effects of codeine and oxycodone are very similar to one another when taken at equivalent doses. In the amounts you're talking about, based on your experiences, adding the codeine would probably just boost whatever oxy you take to feel like a slightly higher dose. That being said, I still recommend against it because you never know how you'll react to a new drug and combining it with another as potent as oxycodone is not necessarily the smartest idea. Just my two cents.
     
  3. Marvolo

    Marvolo Mercury Member

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    The codeine is likely not noticeable. On its own 60mg codeine converts to 6mg oxycodone. When taken in combination it will likely be less.

    To the previous post, however, 2g paracetamol in a single dose, having not taken paracetamol at all that day, is not really dangerous. Combining opioids both acting on the same opioid receptor do not have a synergistic effect. In fact it is possible one will slightly displace the other (as seen with buprenorphine) and lower the effect. Combining different types of CNS depressant is where the problem lies (such as opioids and benzos).
     
  4. baZING

    baZING

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    I'm sorry, but it is never excusable to be taking anything more than 1000mg of APAP for one's own safety. APAP toxicity is the number one cause of acute liver failure in the United States. CWE is not rocket science, and 2g of APAP taken enough times will have its eventual impact. There's simply no reason to jeopardize one's health for the minor convenience of not performing a CWE. APAP does little to potentiate the opiate high, though it does potentiate analgesia-- so if you're still determined to take the APAP as well, take 1000mg or less and perform a CWE on the rest of the dose. It's not really an arguable point. One method is simply safer than the other, at least in terms of negative effects to the liver.