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Combinations - Oxycontin and Tramadol?

Discussion in 'Opiates & Opioids' started by Parliament, Mar 26, 2010.

  1. Parliament

    Parliament Newbie

    Reputation Points:
    Mar 26, 2010
    from U.S.A.
    I want to know if he can mix Oxycontin and Tramadol?? He is using Oxycontin 80's and he is snorting 40-60mg per day, he wants to know what would happen if he took a couple of tramadol while using Oxycontin. He is also drinking 6-8 beers per day.
  2. 5HT-Receptor

    5HT-Receptor Silver Member

    Reputation Points:
    May 9, 2009
    from U.K.
    Interactions between:

    Oxycodone <-> Tramadol

    MAJOR interaction

    GENERALLY AVOID: Concomitant use of tramadol increases the seizure risk in patients taking other opioids. These agents are often individually epileptogenic and may have additive effects on seizure threshold during coadministration. CNS- and respiratory-depressant effects may also be additive. In patients who have been previously dependent on or chronically using opioids, tramadol can also reinitiate physical dependence or precipitate withdrawal symptoms.

    MANAGEMENT: Concomitant use of tramadol and other opioids should be avoided in general. Tramadol should not be used in opioid-dependent patients, and use in patients who are chronically on opioids is also not recommended. Tramadol is contraindicated in patients with acute opioid intoxication. Tramadol dosage should be reduced if it must be used in patients receiving opioids. Patients should be monitored for development of seizures and CNS and respiratory depression.
    Last edited: May 17, 2011
  3. fiveleggedrat

    fiveleggedrat Palladium Member

    Reputation Points:
    Nov 28, 2007
    from U.S.A.

    1) Yes, respiritory depression combined is additive yes, but a MAJOR interaction? No.

    2) Major seizure risk from tramadol + opioids? What? First time swim EVER heard this.

    Swim extensively used and researched BOTH tramadol and oxycodone over the past few years. The dangers here are overplayed.

    Mixing downers is a bad idea in general.

    Tramadol's seizure issues come from the SSRI SNRI components it has, and not the opioid.

    OP: If You is eating that much oxy daily, the tramadol would do next to nothing. Swim compares 300mg tramadol (the ceiling of it!) to about 15-20mg oxycodone, MAX, in terms of general potency. And it won't stack more euphoric opioid effects with the oxy.

    Oxy + tram + beer = big suffocation party.

    Above poster, PLEASE do NOT repost generic, Drug industry sanctioned "info" from drugs.com. We might as well ask Dr. Sanjay Gupta and NIDA to provide info.
  4. Helene

    Helene Gold Member

    Reputation Points:
    Jul 27, 2009
    from U.K.
    I can't find any info that tells me for sure if this applies to oxycodone or not, but I know for a fact that taking tramadol with methadone actually reduces the efficacy of methadone. Going by this information, it seems that tramadol interferes with the levels of other opiates in ones body, and can send an opiate-dependent person into withdrawal by lessening the effect of the opiate they are dependent on.

  5. Master_Khan

    Master_Khan Silver Member

    Reputation Points:
    Apr 12, 2009
    from vanuatu
    So You is mixing alcohol and oxycodone and wants to know if throwing a couple of tramadol on the bonfire would be OK?

    Not a very good first post. This is a harm reduction site, You shold not expect anyone here to encourage this. Snorting oxy increases the potential for dependance and addiction. Using oxy in conjunction with alcohol increases the chance of dangerous respiratory depression. Risk of seizures from Tramadol are higher for those with a history of alcohol abuse.

    Not a great idea.
  6. The.KK

    The.KK Silver Member

    Reputation Points:
    Dec 20, 2006
    from afghanistan
    I don't know too much about this. However, he's thinking if a synergy or potentiation could be possible. Tramadol affects the mu receptors in a certain way and many other neural systems as well. Oxycodone also affects the opioid system in its unique way and other systems too. A combination could be a nice high. Even if due to tolerance the effects will not be felt strongly the high will be felt differently due to activations that might help one another.

    This is considered disregarding the possible dangers that might exist.