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Drug info - PB-22 (1H-indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester) Drug Info

Discussion in 'Cannabinoids' started by Basoodler, Dec 8, 2012.

  1. Basoodler

    Basoodler Titanium Member

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    Can anyone add information about PB-22 - Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate

    • names / synonyms
    • molecule i
    • dose
    • duration
    • side effects
    • legal status
    • have there been any reported incidents with this compound?
    • since when has this Research Chemical been available?
    • stability of the molecule / compound


    [​IMG](best I could find atm)


    IUPAC: Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate / 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (not sure which is best)

    CAS number: 1400742-17-7

    Formula: C23H22N2O2

    *the IUPAC and CAS do not turn up any hits aside from RC vendors

    There is also a 5f-pb-22 which is being directed toward the Russian market

    Please post any information about PB-22 in this thread

    All experiences are to be put in the experience thread: If you are the first person with an experience to post please follow the format for an experience thread: I will link it here.



    INFO I found researching:

    I saw pb-22 which is.... Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate.

    I researched a bit and found a ton of references to Quinoline based cannabinoids in recent publications.. But the ones I found were about use as selective cb2 agonists.. I kind of left it at that.

    Then today I see a damn analog called 5f-pb22.. Sold as a replacement for 5f-akb48.

    Now I am a bit confused..I guess any substitution can change receptor binding.. Or are cb2 agonists just as psychoactive?

    Studies:

     

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  2. mrlegalizeweed

    mrlegalizeweed Newbie

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    I will be reviewing this soon, Source tells me it's the next big cannabinoid, extremely new. Almost nobody has it but in a month, it'll probably be available for research...
     
  3. Docta

    Docta Idiot Savant

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Quinolin-8-yl 1-pentyl-1H-indole-3-carboxylate is correct for the image you have posted.

    [​IMG]

    [​IMG]
     

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  4. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Thanks! At the time I only had the made up name and iupac.. I found the little molecule pic trolling the web.

    I assume this one would not fall under the analogue act because I've never seen Quinolin in any of these.. is that correct?

    There is also a 5f-pb-22 but I didn't get the iupac on it.
     
  5. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Just came across this blurb on a legal website http://incenselaw.com/front-page-featured/florida-takes-a-firm-stance-on-incense-its-illegal/ <-- linked to the blog

    they are a legal team that represents and aids cannabinoid vendors through testing of the product to make sure it complies with the new laws.. they do not sound very optimistic

    full blog entry on DF http://www.drugs-forum.com/forum/showthread.php?p=1233469#post1233469

    that is in regard to Florida.. just thought I would point that out though..
     
  6. mrlegalizeweed

    mrlegalizeweed Newbie

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    This cannabinoid will change the market slightly. You will need a basic knowledge of chemistry to research this chemical, more so than with other cannabinoids of the past. This is meant to be a legal solution for us researchers. We need to keep this in the hands of licensed researchers (like me) and away from these incense weirdos.
    I will be reviewing how the drug affects my bonsai tree's growth.
     
  7. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    You can't give an ominous reply like that :p.

    Please give some detail into what the differences are. I'm sure everyone would appreciate it :)


    The one person that I've spoke to briefly said it was very close to the natural .. But he is a stoner .. So I took it with a grain of salt :p
     
  8. stryder09

    stryder09 Silver Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    It contains an indole core structure with modifications to certain part of the molecule. This is the only thing the DEA is using in regards to prosecuting analog cases (see the UR-144/XLR-11 cases in the other forums). IF the substance is used and a manufacturer/retailer is caught selling it, I would fully expect the DEA to charge them with posessing a controlled substance analog. Also keep in mind that the other part of the analog enforcement act is pharmacological effects. Well, with the above stated literature citations, it is shown to be a CB1/CB2 agonist. Ultimately, the analog determination is a court decision and not a strict definition of the DEA.

    Now, do other independent (non-DEA) scientists agree with the structural similarity assessment? Some will...some won't. I'm in the camp that it is not structurally similar "enough" to JWH-018 or any other controlled synthetic cannabinoid.

    Just be careful, people. That's all I can say.

    Stryder09
     
  9. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    I think that is what the quote is telling people who think they can get by with it. If you hit the link below the quote I linked their website which is rich with archives of legal advice. Before log jam that firm was dictating what chemicals to use to skirt laws and testing the noids before they were put on substrate .

    Now they are telling people not to fuck with it.. I think its very telling

    Edit they have changed the site to an open letter warning now

    http://incenselaw.com/

    There you have it
     
    Last edited: Jan 6, 2013
  10. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    All that tells me is that they were charging no doubt extortionate fees to give people bad legal advice. If this firm was dictating which chemicals they considered to "skirt the law" then they were not doing their job, because even someone with a basic understanding of US drug law knows that that reach of analogue legislation only becomes apparent in the courtroom. Nothing has changed as a result of Log Jam other than enforcement, and anyone involved in the industry should've been well aware for a number of years that enforcement was a very realistic possibility given the nature of the market. Now it seems this firm are setting themselves up as self-professed expert consultants on all things Log Jam so that they can continue to coin it in. Seems to me their track record shows incompetence that is not fitting with that role.

    Of course readers of this site have been getting legal status warnings for at least 2 or 3 years. And we don't even charge a fee!
     
  11. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    lol I understand that ^ .. I just mean they have REALLY changed their story in the last 3-5 days.. its gone from "Fight the Power" to "oh shit give up" on that web page very quickly :)

    I am honestly shocked it has lasted as long as it has

    You know those lawyers were the real winners in the whole thing... they basically legally obtained a shit ton of drug money.. it doesn't matter if they win or lose.. they got paid
     
    Last edited: Jan 6, 2013
  12. mrlegalizeweed

    mrlegalizeweed Newbie

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    I'm sorry, I realize I sound like an elitist. That's NOT where I'm coming from, and I want to help because I understand your perspective. I promised to not even write about this, because believe me law enforcement is reading my post (you disgust me) If you seem trustworthy and have a presence here, pm me for info on this. I'm not saying keep quiet, but don't post about it openly or your literally stopping me from helping you. Review either tomorrow afternoon or the next afternoon.

    Even just this gives me anxiety. I could lose my licenses. But I'm putting my ip address out there because I want to help with harm reduction. (And valid research, but this post on this particular forum is for harm reduction. I am a realist after all) As a medical professional, a humans safety is really important to me. I want you all to know that I genuinely value your safety, but it's time for a slight change in this market. What's going on right now is a lose-lose for us and the government, except a handful of guys who have gold logs jammed up their asshole.
     
  13. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Unless you're willing to verify your medical credentials please make no such assertions. More often than not when a member professes such expertise rather than letting the quality of their posts speak for itself, their expertise is in reality non-existent.
     
  14. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    ^ is paranoia a strong side effect of pb22.

    If you can't say for whatever reason that's fine.. Myself I don't even mess with these anymore. This forum is just an information hub that can provide knowledge to others which will hopefully be used to keep them safe. At least that's why I am here.

    So its cool if your not comfortable.
     
  15. wicked2010

    wicked2010 Silver Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    you are a "medical professional" and have "licenses", and you are only 22???
     
  16. DrBD

    DrBD Silver Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    PB22 would definitely fall under the less conservative interpretation of a structural analogue of many already illegal synthetic cannabinoids. I also highly doubt it is drastically different from any of the myriad of previously reported indole cannabinoids. That aryl ester looks ripe for in vivo hydrolysis. Short half-life is my guess.

    ...Just my $0.02. I'm not a "medical professional", but I always seem to know more about drugs than the people prescribing them. I don't think being a doctor makes your information (opinion) particularly insightful, unless it derives from clinical evidence. If you have info that aids harm reduction then please share.
     
  17. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Barring some miracle legal breakthrough on the part of the synthetic drug defense (which doesn't have a snowballs chance) I don't see this market remaining much longer..

    Two of the biggest cases from operation log jam ended with no fight what so ever.. Just guilty pleas.. Over the next few months as these guys start dropping like dominoes and increasing prison population. There won't be a retailer left with the stones or ridiculously stupid to make or sell it outside of the black market.

    Any hopes that any of these will be widespread hits in the USA were dashed last July.. All right , nothing to see here , move a long home.

    We are all left with a cool memory of buying strong drugs at gas stations like twinkies .. And maybe some worry about having ingested so many random drugs in a 5 year world wide fuck all party that historians are going to struggle to describe correctly :)

    And boy did the party go to shit in the end

    Basoodler added 0 Minutes and 16 Seconds later...

    Barring some miracle legal breakthrough on the part of the synthetic drug defense (which doesn't have a snowballs chance) I don't see this market remaining much longer..

    Two of the biggest cases from operation log jam ended with no fight what so ever.. Just guilty pleas.. Over the next few months as these guys start dropping like dominoes and increasing prison population. There won't be a retailer left with the stones or ridiculously stupid to make or sell it outside of the black market.

    Any hopes that any of these will be widespread hits in the USA were dashed last July.. All right , nothing to see here , move a long home.

    We are all left with a cool memory of buying strong drugs at gas stations like twinkies .. And maybe some worry about having ingested so many random drugs in a 5 year world wide fuck all party that historians are going to struggle to describe correctly :)

    And boy did the party go to shit in the end
     
    Last edited: Jan 8, 2013
  18. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Pb-22 is sold as a knock off brand of blueing. There are no specific instructions on how to make crystals.

    I am pretty sure its packaged as dye as well.. If I'm not mistaken almost all of the quinolen dyes like yellow #17 ect.. Are very closely related.. Which makes it difficult to test for..I think NNE1 is based on dye as well.

    Drdb knew what I was talking about. I've not seen a single trip report on this one other that comparisons of pb22 and 5fpb22 in a trip report for 5fpb22. Which said pb22 did not cause as much anxiety or nausea.
     

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  19. bravedog

    bravedog Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    In another thread DrBD says "Both PB-22 and BB-22 [and 5f-PB-22] (probably) produce a common metabolite in vivo: 8-hydroxyquinoline...There are multiple reports of its antifungal/antimicrobial activity, but also some evidence that it causes diabetes in some animals. Seems like it is definitely pharmacologically active and with diverse properties. Take care... " Comments?

    Another of the new batch, NNE1, is supposedly quite possibly carcinogenic.


    While little is known about many of these chemicals, I wonder if the new ones appear actually less safe than previously available 'noids, or if I've missed info on specific dangers for older specific chemicals? If the latter links to info would be helpful. Thanks
     
    Last edited: Jan 19, 2013
  20. Basoodler

    Basoodler Titanium Member

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    Re: pb-22: 1H-Indole-3-carboxylic acid, 1-pentyl-, 8-quinolinyl ester (on the market

    Safer / less safe is hard to decipher because there is no data. This Bach of new ones looks to be designed to evade laws.. I wouldn't smoke anything after the 2nd wave.. Just because the third wave seemed to be hitting more than cb1 or cb2 with those weird ass side effects