Drug info - pFPP (Flipiperazine, para-fluorophenylpiperazine) Drug Info

Discussion in 'Research Chemicals' started by Alfa, Feb 16, 2006.

  1. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    PFPP. (p-Fluorophenylpiperazine. Aka Flipiperazine).

    Works mainly on the serotonine system and creates changes in sensory perceptions. Effective dose is 20 mg and effects last for around 3 hours. A significant portion of users experience migraines and naussea. Especially when taking over the reccomended dose.

    The research done on this compound seems to be very limited:

    Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001.

    [SIZE=+1]Molecular pharmacology of niaprazine.

    Institut de Biologie Physico-Chimique, Paris, France.

    1. The pharmacological profile of niaprazine was investigated using in vitro ligand binding techniques. 2. Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, alpha 2, beta, H1 and muscarinic cholinergic receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for alpha 1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites (Ki sigma mciroM). In contrast, p-fluoro-phenylpiperazine, a major metabolite of niaprazine, exhibits a higher affinity for the 5-HT1 subclasses than for the 5HT2 class. 3. These results suggest that the pharmacological properties of niaprazine reflect both its non-reserpinic catecholamine depletor effect and its action on alpha 1 and 5-HT2 receptors. A role of p-fluoro-phenylpiperazine via 5-HT1 sites cannot be excluded.
    Neuropharmacology. 1982 Feb;21(2):163-9.

    [SIZE=+1]The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain.

    Niaprazine (60 mg/kg i.p.) increased rat brain 5-hydroxyindole acetic acid (5-HIAA) concentrations 30 min after treatment, and reduced them at 3-8 hr after treatment. Rat brain 5-hydroxytryptamine (5-HT) levels were unchanged. Niaprazine also produced a short-lasting depletion of rat brain noradrenaline (NA) and dopamine (DA). Pretreatment with alpha-phenyl-alpha-propyl-benzeneacetic acid, 2-(diethylamino) ethyl ester hydrochloride (SKF 525A) (75 mg/kg i.p.) potentiated the increase in 5-HIAA and depletion of catecholamines produced 1 hr after niaprazine, but abolished the reduction in 5-HIAA produced 8 hr after the drug. This suggested that a metabolite might be responsible for the delayed reduction in 5-HIAA levels. A potential metabolite, p-fluoro-phenylpiperazine (FPP) (5-40 mg/kg i.p.) reduced rat brain 5-HIAA and 3,4-dihydroxyphenyl acetic acid (DOPAC), and inhibited 5-HT and NA uptake in vitro. Unlike niaprazine, FPP produced no behavioural sedation, but in large doses produced a behavioural syndrome indicative of serotonergic stimulation. Studies of the metabolism of 14C-niaprazine in rats indicated the presence of a urinary metabolite with the same chromatographic characteristics as FPP. These results suggest that niaprazine itself depletes brain catecholamines and increases 5-HT turnover, while a metabolite, FPP, subsequently reduces the turnover of 5-HT and DA.
     
    Last edited: Sep 10, 2017
  2. Cuberun

    Cuberun Gold Member

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    Do you know which sort of "brand mixes" contain flipiperazine (that sounds so gimmicky).
     
  3. Thirdedge

    Thirdedge Gold Member

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    Flipiperazine

    MASH. 37.5mg per capsule. Its a mildly psychedelic downer, kinda like taking a Benzo and a 2 shrooms at the same time.

    Flipiperazine was first synthesised in New Zealand. I didn,t experience a migraine from 2 capsules / 75mg of Mash, but did notice mild nausea, similar to that of approx 50mg of TFMPP.
     
    Last edited: Feb 12, 2010
  4. Forthesevenlakes

    Forthesevenlakes Platinum Member

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    seems odd to SWIM that piperazines can bind so many types of receptors and have a wide range of subjective effects. SWIM always just assumed every piperazine was somewhat like amphetamine, but maybe thats just BZP. and by odd, i mean interesting. I will definitely have to read up on their pharmacology, even if he has no interest in ever trying any of them.
     
  5. JewishNazi

    JewishNazi Gold Member Newbie

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    Why dont you think of amphetamien as an atypical PEA?
     
  6. darrinotago

    darrinotago Newbie

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    fliperazine

    Any one used this on its own or mixed with anything any comments welcomed thanx:cool:
     
  7. Thirdedge

    Thirdedge Gold Member

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    Re: fliperazine

    Swim used it once, probably wouldn,t bother again. Similar to TFMPP but with toxic side effects from even a mild dose. Many of these other Piperazines (other than bzp / viagra etc) are pretty crappy really, they give a buzz similar to the nausea stage of a Hawaiian Baby Woodrose trip.
     
  8. Nagognog2

    Nagognog2 Iridium Member

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    Re: fliperazine

    This crap is poison and is used to kill intestinal worms in farm animals. Yummy - Yum - Yum!!

    Re-Opened by GOD
     
    Last edited: Oct 23, 2006
  9. stjbm06

    stjbm06 Newbie

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    Re: PFPP (Flipiperazine).

    OK, SWIM just got 6 grams of this shit FREE and needs some advice OTHER than "this crap is poison"... I have full intention of trying this first at a very safe dose, then increasing, but wants to know whether he is being the first guinea pig out there and at what dose one could see some actual effects and what to expect so he doesn't freak out.

    peace
     
  10. Thirdedge

    Thirdedge Gold Member

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    Re: PFPP (Flipiperazine).

    No, You is not beeing the first guinea pig for this chemical - it is widely available in a commercial product as mentioned above.
    Said product contains 37.5mg per capsule, this is what swim tried.
    I recomend You get some good scales and measure out 20mg for a mild dosage or 40mg for a strong dosage. Higher dosages than 40mg are likely to involve side effects such as nausea and headache.
    It is worth noting that in NZ where these sorts of things are widely available, most prefer bzp or bzp with tfmpp. Most try these more novel substances once or twice as an experiment and then move on.
     
  11. starboy

    starboy Silver Member

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    Re: PFPP (Flipiperazine).

    This chemical, like BZP was a metabolite of a medicine which would have gone through trials before being marketed, so you are not going to be the first person to consume it.

    The pleasant margin is in the "up to 20mg" dose range, some marketers apply marketing formula to this dosage and produce higher dosage products for a better price hoping to boost sales without realising that the nausea and headaches negate any advantage that may have been gained by the price comparison, and then providing 5HTP pills with them as though 5HTP is a magic bullet for comedowns makes matters worse, in some cases increasing unpleasant side effects.

    Less is more.

    Headaches respond well to ibuprofen.
     
  12. bushman

    bushman Silver Member

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    Re: PFPP (Flipiperazine) basics

    Any information on effects when not mixed with other things? Is it worth using as a stand alone substance? I have heard that:

    "pFPP has little stimulant effects, with its subjective effects derived mainly from its action as a 5HT1A agonist. Its effects have been described as similar to a cross between Fluoxetine and a very small dose of LSD, both of which have significant actions as 5HT1A agonists in addition to their primary mechanism of action."

    SWIM wonders wether pFPP really has mild hallucinogenic qualities?
     
  13. Blue carbon

    Blue carbon Newbie

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    Re: PFPP (Flipiperazine) basics

    I took about 30mg of pFPP(full stomach) and thinks that this substance has potential. SWIM know about piperazines bad opinion but thinks that this one is worth-trying. It is incredibly cheap(in powder form, not in pills) and for I am empathogen/euforant. Its psychedelic values are not interesting(in compare to 2c-e). There are no noticeable side effects like nausea or something. Pulse is normal, about 65. I did'nt measure the blood pressure but thinks its normal. SWIM know that the dose he have took is not too big, but I like it in that dose.
     
  14. US_BLUES

    US_BLUES Newbie

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    Re: PFPP (Flipiperazine) basics

    I have heard about this Research Chemical lately. Reports seem to indicate it does not have most of the negative aspects of other piperazines. Under 50mg doses do not seem to cause the same intestinal problems with BZP, or other piperazines.
     
  15. chemman

    chemman Silver Member

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    Re: PFPP (Flipiperazine) basics

    This is a very good substance. I was with her a few experiments. Recalls MDMA + LSD in small doses. The average dose is 40-60mg (for the dichloride). Effects persist about 5h.
    Substance produces:
    - Relax
    - Poor visual with open eyes
    - Pretty good CEV
    - Mild euphoria and empathy
    - Shivering and feeling cold
    - And sometimes can cause headache

    Is very good to combine with other substances. MeOPP + pFPP gives almost the same effect as MDMA. I feltthe same as the first XTC.

    pFPP also prolongs the action 4-MMC. Mephedrone then takes about 3 hours. Should be proud to go in a slightly larger dose than usual.
     
    Last edited by a moderator: Mar 29, 2010
  16. FriendlyToker

    FriendlyToker Newbie

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    Some say MeOPP + pFPP gives GREAT feelings, and some say it's the worst combo ever. Somebody've got a brownish 3:1 MeOPP+pFPP mix, is it snortable? Someone was thinking of snorting 15-20mg pFPP (so ~20pFPP and 60MeOPP that would be). Someone doesn't care about the noseburn, the question is whether they are more potent when snorted or not, and if this is a good first time dosage.