Pharmacology - Pharmacological workings of Psilocin and Psilocybin

Discussion in 'Magic Mushrooms (Psilocybe & Amanita)' started by pharmapsyche, Nov 20, 2005.

  1. pharmapsyche

    pharmapsyche AKA Miss Methylene Titanium Member

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    Oct 17, 2005
    Pharmacological workings of Psilocin and Psilocybin

    Psilocin and Psilocybin are the two main psychoactive compounds found in "magic mushrooms". When chemically speaking Psilocin is an alkaloid and a tryptamine. Psilocin is the pharmacologically active agent in the human body after ingestion of Psilocybin, but still both Psilcoin and Psilocybin have the same pharmacological properties. Psilocybin, also known as 4-phosphoryloxy-N, N-dimethyltryptammine, is known most commonly as a psychedelic alkaloid. Psilocybin is contained in fungi.

    Psilocin, which is the active metabolite of Psilocybin, mimicks the action of the neurotransmitter receptor ‘serotonin’, also known as 5-HT. Psilocin has interaction with neurotransmitter receptors on nerve cells within the brain, which is how it begins to act like serotonin. Psilocin is more chemically stable than Psilocybin, because it has a greater molecular weight and also because Psilocybin is far less potent than Psilocin. Psilocin is a post-synaptic serotonin-2a receptor agonist. Hallucinogens such as LSD and mescaline work the same way.

    LSD and Psilocybin show a definite cross-tolerance of one another, when taking either one of these substances. The brain promptly develops a tolerance to the drug, which means if taking another dose soon, it will be essential to take a higher quantity of the drug than before to achieve the desired effects.

    An active dose for psilocybin ranges from 3 to 30mg’s. Duration for the drug is commonly reported anywhere from 4 to 7 hours. Edited by: pharmapsyche
  2. fatmanstan

    fatmanstan Titanium Member

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    Jan 29, 2006
    from The Netherlands
    I was always under the impression that psilocybin was more stable, and psilocin oxidized easily. I also thought that psilocybin was metabolized to psilocin in the body.

    Could be wrong though.
  3. radiometer

    radiometer bananadine addict Platinum Member & Advisor

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    Apr 13, 2005
    from U.S.A.
    It's been suspected for a while now that baeocystin and nor-baeocystin also are active constituents of psilocybe mushrooms. I'd be interested to read more about that subject.

    FMS, although it's never been proven, the theory that psilocybin is rapidly converted to psilocin in vivo is well-accepted and generally agreed-upon.