Other - phenethylamines related to phenelylanines?

Discussion in 'Phenethylamines' started by pillz, Apr 27, 2007.

  1. pillz

    pillz Newbie

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    I was recently doing research on phenethylamines and MDMA was in the phenethylamines category. however swim knows someone who is currently taking phenelylanines for migraines and this medication is also involved with seretonin. swim knows that migraine attacks are involved with low levels of seretonin. swim also ran across something on a reputible site that says something that phenethylamines can be synthesized from phenethylanines. basically swims question is: are the two categorys of drugs related in some way on some level( even though phenethylamines are generally illicit drugs) because of serotonin distribution?
     
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  2. Nagognog2

    Nagognog2 Iridium Member

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    To fully understand how phenethylamine-based psychedelics are related to serotonin requires an understanding of organic molecular chemistry. Then if one were to draw out the molecules and study them, the answer would be obvious. Other than advising you to study chemistry, suffice to say that they are related.
     
  3. pillz

    pillz Newbie

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    I has not personally searched into phenethylamines yet so swim just thought that he would ask if someone knew. but I will def. do more research and the next post about phenethylamines will possibly be informative, as opossed to asking
     
  4. fastandbulbous

    fastandbulbous Titanium Member

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    Do you mean phenylalanines (substituted variants on the amino acid phenylalanine)?

    Yon can overlay the molecules of phenethylamine hallucinogens and serotonin so that the parts involved with binding to the receptor are pretty much in the same place. That's what's required to produce a psychedelic effect (technically agonism at the 5HT2a receptor). If you look at the LSD molecule, it contains both a phenethylamine & a tryptamine skeleton within it's structure (there's a variation on the word search sort of puzzles!) - LSD being an example of one of the most potent 5HT2a agonists known (so a good place to start)