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Combinations - Possible conflict subutex and morphine

Discussion in 'Opiates & Opioids' started by scored, Apr 30, 2009.

  1. scored

    scored Silver Member

    Reputation Points:
    Dec 5, 2008
    from U.K.
    Your input is greatly appreciated here. I am a long term subutex user, recently addmitted to hospital with various serious health complications. Due to severe chest pains was put on morphine on top of her subutex. Eventually a dugs worker at the hospital pointed out that subutex is a partial blocker. She was taken off subutex and her morphine upped to 250 ml. On discharge from hospital her 8mg subutex script is back and she is on 100ml oral morphine.

    Can someone explain how much of the morphine could be blocked. She is complaining of symptoms which sound like withdrawl and still in considerable pain.

    She has a GP appointment tomorrow (friday) and would like to attend armed with some knowlege to educate her GP.

    My unprofessional diagnosis would be to remove the subutex, but then what do I know? I havent been to med school.
  2. Solinari

    Solinari Titanium Member

    Reputation Points:
    Oct 23, 2007
    from U.K.
    a LOT of morphine will be blocked because subutex (buprenorphine) has an extremely high affinity for the mu opioid receptor which can't even be kicked out by an antagonist such as naloxone which also has very high affinity.

    This is just a guess on my part but i imagine more buprenorphine would be more effective than morphine, the partial agonist/antagonist effects of buprenorphine much also be a consideration. I tyhink there is another thread about this going around.