1. Dear Drugs-Forum readers: We are a small non-profit that runs one of the most read drug information & addiction help websites in the world. We serve over 4 million readers per month, and have costs like all popular websites: servers, hosting, licenses and software. To protect our independence we do not run ads. We take no government funds. We run on donations which average $25. If everyone reading this would donate $5 then this fund raiser would be done in an hour. If Drugs-Forum is useful to you, take one minute to keep it online another year by donating whatever you can today. Donations are currently not sufficient to pay our bills and keep the site up. Your help is most welcome. Thank you.
    PLEASE HELP
    Dismiss Notice

Drug info - Possible to get a buzz/high from 5-HTP?

Discussion in 'Nootropics' started by Lettish, Dec 14, 2007.

  1. Lettish

    Lettish Titanium Member

    Reputation Points:
    202
    Joined:
    Nov 2, 2007
    Messages:
    350
    Male from U.K.
    My friend's looking into 5-HTP recently, he's very fascinated by it. He can't seem to find any information about the above question though.

    As far as he is aware, 5-HTP produces serotonin but does not necessarily release it (like MDMA does). His question is, if enough 5-HTP was consumed to produce enough serotonin, would the body try to release it? And if so, would that release give him a buzz/high?

    Secondly, if he consumes 5-HTP to produce serotonin, and then consumes MDMA, would he experience a better/stronger/higher trip?
     
  2. sterling77

    sterling77 Iridium Member

    Reputation Points:
    233
    Joined:
    Apr 21, 2005
    Messages:
    661
    Male from denmark
    The mechanism of serotonin production is under repressible control- meaning it prevents excess amounts of accumulated serotonin by slowing down production, aka feedback inhibition. That being said, swim has felt a pleasurable "high" a handful of times but it is hit or miss. It usually just consists of a drowsy type of feeling. For the question about mdma UTFSE.
     
  3. Lettish

    Lettish Titanium Member

    Reputation Points:
    202
    Joined:
    Nov 2, 2007
    Messages:
    350
    Male from U.K.
    My friend says it's hard to search for the answer to a question like that, without sifting through pages of threads. Keywords? MDMA, 5-htp, trip. Extremely common in this forum. Isn't it just easier for someone to give the answer again?
     
  4. chrisn

    chrisn Gold Member

    Reputation Points:
    544
    Joined:
    May 29, 2007
    Messages:
    346
    Male from U.S.A.
    Hydroxy, check out this Erowid report: http://www.erowid.org/experiences/exp.php?ID=42885

    It certainly seems to indicate the possibility of the combination being amazing, however I do wonder about the safety of such a high amount of 5-htp and whether serotonin syndrome would be a risk. Can anyone comment on the safety of what the person in this erowid report did?
     
  5. fnord

    fnord Newbie

    Reputation Points:
    2,475
    Joined:
    Dec 8, 2003
    Messages:
    4,434
    Male
    a friend of mine and another user of this forum hempy666 has a friend who has injected 5-htp cant remember what his friends results were.(pm him with a link to this thread if you want to know)

    grandma loves 5-htp she finds it increases the effects of pot and dxm greatly even thought many claim mixing it with dxm is risky,she has yet to find/see any evidence confirming that anyone has had problems mixing these two.
     
  6. Lettish

    Lettish Titanium Member

    Reputation Points:
    202
    Joined:
    Nov 2, 2007
    Messages:
    350
    Male from U.K.
    My friend says thanks for the responses - he found an old thread after sifting through this forum. He notices much talk of piracetam and 5-HTP. Some people say 5-HTP hasn't enhanced the roll at all, in fact in some cases it weakens it. Others say it makes their roll better. Strange how it varys. My friend guesses there's only one way to find out how it affects him... He is just unsure how much to take.
     
  7. meep

    meep Newbie

    Reputation Points:
    92
    Joined:
    Oct 19, 2006
    Messages:
    253
    Male from U.K.
    Swim finds 5-HTP will give him a mild mood lift in the form of patience but once that wears off, swim will feel sleepy (which is almost never when hes stright)


    Swim always preloads and doesn't notice an different on the roll, the preload is all about the day after. Swim finds preloading 100mg of 5-HTP each night, 5 nights before the roll and 100mg the morning of his roll then 300mg the morning after his roll bring his head round quicker and has yet to suffer the crippling blues he once had without 5-HTP.


    L-tyrosine give a caffeine type buzz and gives the initial come up a speedy buzzy feel that fades into the roll nicely though.

    If swiy's not planning to preload that week, take around 400mg. Some say it can make you feel sick but swim never does - this has not affected swims roll he doesn't think.
     
    Last edited by a moderator: Apr 30, 2017
  8. fnord

    fnord Newbie

    Reputation Points:
    2,475
    Joined:
    Dec 8, 2003
    Messages:
    4,434
    Male
    many say that comining 5-htp with serotonegic drugs can cause serotonin syndrome grandma has taken massive doses of 5-htp along side pot and heroic dxm doses in the distant past without a single problem besides once her brain farted for a day.

    http://www.drugs-forum.com/forum/showthread.php?t=29660&highlight=5-htp
     
  9. meep

    meep Newbie

    Reputation Points:
    92
    Joined:
    Oct 19, 2006
    Messages:
    253
    Male from U.K.
    Swims packet of 5-HTP is sold in the form of sleep aids (which it also does, very well) and 2 before bed are advised. Each pill is 100mg.



    It might well have been this granny that turned swim onto the idea of 5-HTP with pot and it certainly goes well.
     
  10. Jacco

    Jacco Newbie

    Reputation Points:
    42
    Joined:
    Jul 28, 2007
    Messages:
    126
    Male
    Swim wonders about combining 5-HTP with 5-HTP->5-HT enzymes or drugs that encourage production of serotonin. Do such exist?
     
  11. Paracelsus

    Paracelsus Platinum Member & Advisor

    Reputation Points:
    3,120
    Joined:
    Aug 31, 2006
    Messages:
    2,514
    Male from U.S.A.
    Jacco: 5-HTP is converted to serotonin by l-aromatic amino acid decarboxylase, which is present in large amounts just about anywhere in the body. Consuming more of the enzyme would not do much except if taken in heroic doses.
     
    Last edited by a moderator: Dec 16, 2007
  12. Micklemouse

    Micklemouse Platinum Member & Advisor

    Reputation Points:
    4,681
    Joined:
    Feb 18, 2004
    Messages:
    3,322
    Male from U.K.
    Or if clinically deficient in it...

    From The National Dysautonomia Research Foundation (NDRF)

    http://en.wikipedia.org/wiki/Aromatic_L-amino_acid_decarboxylase

    Cannot find any info on effects of excess of AAAD, but I'll keep looking. Meanwhile, if not clinically diagnosed, by a professional, with a deficiency there should, as Paracelsus states, be no reason to supplement.
     
  13. Lettish

    Lettish Titanium Member

    Reputation Points:
    202
    Joined:
    Nov 2, 2007
    Messages:
    350
    Male from U.K.
    My friend is doing a little experiment. He is going to consume MDMA on 5-Jan-08. On 17-Dec-07 he got some 5-HTP and has been taking 3 x 100mg daily. He will continue this dosage until 5-Jan-08 and see what happens.

    What he has discovered so far, even after just six days of dosing, his mood has generally been a lot happier and he is sleeping so much better. Is this normal or is this just placebo?

    He will post his findings here after the 5-Jan-08 event.
     
  14. meep

    meep Newbie

    Reputation Points:
    92
    Joined:
    Oct 19, 2006
    Messages:
    253
    Male from U.K.
    Totally normal. Cant recomend 5-HTP enough.
     
  15. Jucifer

    Jucifer Newbie

    Reputation Points:
    0
    Joined:
    Jul 25, 2007
    Messages:
    16
    Male from U.S.A.
    SWIM once took 200mg of 5-HTP for 3 days and noticed that he felt happier, and in a better mood than normal. SWIM also said that during this time period his HPPD was more noticable.
     
  16. Euphoric

    Euphoric Newbie

    Reputation Points:
    2,654
    Joined:
    Aug 21, 2006
    Messages:
    1,381
    Male from Canada
    What was his HPPD a result of? Any theories on why extra serotonin may increase symptoms of HPPD?
     
  17. lago

    lago Newbie

    Reputation Points:
    0
    Joined:
    Jan 13, 2008
    Messages:
    4
    Male
    SWIM discovered the combination of 5htp and piracetam consistently resulted in a calm mild euphoria not unlike hydrocodone. It also made the smallest amount of alcohol give him a horrible headache. He also found that slightly larger amounts of 5htp gave him horrible flatulence and caused the opposite of euphoria in his roommate.
     
  18. Zaprenz

    Zaprenz Newbie

    Reputation Points:
    1,002
    Joined:
    Jan 28, 2007
    Messages:
    401
    Male
    It actually makes more pharmacological sense to give 5-HTP with peripheral INHIBITORS of aromatic-L-amino-acid decarboxylase. [Very similar to how L-Dopa is given in parkinson's patients] - Well in theory anyway.

    Why?

    5-HT (Serotonin) does not pass the BBB (Blood Brain Barrier) so any 5-HTP converted in to 5-HT(serotonin) in the blood (by peripheral aromatic-L-amino-acid decarboxylase enzymes) will not get in to the brain and will cause numerous peripheral side effects.

    So the logic:

    E.g Carbidopa (peripherally acting aromatic-L-amino-acid decarboxylase inhibitor, not active inside brain)

    • Decreased 5-HTP -> 5-HT (Serotonin) in blood. (less peripheral 5-HT - good, more remains as 5-HTP )
    • More 5-HTP available & enters via BBB (more 5-HTP converted in to 5-HT(serotonin) inside brain)
    Well that's the theory!

    It works very well for L-Dopa in treating parkinsons disease. However very little evidence of benefit with 5-HTP & possibly more side effects (could be from inhibitors themselves). Essentially not much evidence either way when dealing with 5-HTP & inhibitors.

    The combination may also have more interactions with other medication.

    PMID:16023217

    SWIMS opinion:

    SWIM is not disputing the potential benefit of reasonable doses of 5-HTP but there is probably a upper limit to any "buzz" or pleasant effects one can get from 5-HTP before side effects emerge. It's a bit like L-Dopa, everyone knows dopamine plays a crucial role in the pleasant effects of many drugs but crudely increasing the precursor can lead to quite unpleasant side effects.
     
    Last edited: Jan 13, 2008