potentiation

Discussion in 'Opiates & Opioids' started by intrepid, Apr 15, 2005.

  1. intrepid

    intrepid Newbie

    Reputation Points:
    1
    Messages:
    34
    Joined:
    Feb 11, 2005
    hey, i've been experimenting with opiates for awhile, and have become
    aware of a couple ways to potentiate opiates, but my knowledge is
    limited to benadryl and dxm. does anyone out there know various
    opiate potentiators i can use to help enhance the experience? thanks.
     
  2. Phungushead

    Phungushead Twisted Depiction Staff Member Administrator

    Reputation Points:
    18,173
    Messages:
    3,932
    Joined:
    Jan 21, 2005
    from United States
    <center>C. Boosting Opiates with Cytochrome P450 Inhibitors And Other
    Metabolism Issues
    </font></center>

    1. A dose of Tagamet an hour before a
    hydrocodone/oxycodone session will make the drug last longer and have a better
    effect. Antacids should be taken at least 45 minutes after the Tagamet otherwise
    absorption of the Tagamet will be impaired. Grapefruit juice also has the same
    type of impact on liver enzymes; use a Maalox chaser to neutralise any systemic
    acidification effect from the grapefruit juice. Tagamet should not be taken with
    codeine because it impairs the metabolism into morphine necessary for it to have
    any real effect.
    </font>


    2. Quinine and quinidine accentuate the buzz of opiates but only directly
    help with codeine metabolism by boosting the amount changed into morphine.
    Tagamet and grapefruit juice will weaken codeine substantially. The prescription
    antihistamine promethazine (Phenergan) helps out codeine even more, and is found
    with codeine in the Schedule V cough syrup Phenergan VC With Codeine. Quinine
    will tend to have its effect without impairing hydrocodone but does seem to burn
    off the buzz more quickly and may flatten the dose-to-response curve.
    </font>


    3. With all this liver magic going on and the acetaminophen content of a
    number of the drugs in question, the concurrent use of any alcohol at all with
    any of these mixtures should be thoroughly researched ahead of time. For
    example, washing down 5 Percocets with a vodka gimlet is not a good idea even if
    you have a massive tolerance to the narcotic. Also in many people moderate to
    large amounts of alcohol can change the subjective nature of the high for the
    worse and bring on sleep before the user intends. Anything more than 20 ml pure
    alcohol equivalent is likely to create trouble.

    </font>


    http://opioids.com/opiates/

    </font>
     
  3. bogumil

    bogumil Gold Member

    Reputation Points:
    153
    Messages:
    395
    Joined:
    Feb 12, 2005
    Vitamin E, Gingko, Erythromezin all bind the same as most opies ... Edited by: bogumil
     
  4. sunyata

    sunyata Gold Member

    Reputation Points:
    575
    Messages:
    518
    Joined:
    Dec 16, 2004
    from norway
    Atropine potentiates the effect of opiates, but be carefull, it can kill you in too large amounts.
     
  5. sands of time

    sands of time Gold Member

    Reputation Points:
    361
    Messages:
    1,281
    Joined:
    Nov 4, 2003
    Being that kratom effects the opiate receptors, would these combos work with it as well? I would think that kratom would boost the effects of opiates quite a bit.Edited by: sands of time
     
  6. intrepid

    intrepid Newbie

    Reputation Points:
    1
    Messages:
    34
    Joined:
    Feb 11, 2005
    where exactly can i find tagament? and in what product can i find vitamin E, ginkgo, and erythromezin?
     
  7. Phungushead

    Phungushead Twisted Depiction Staff Member Administrator

    Reputation Points:
    18,173
    Messages:
    3,932
    Joined:
    Jan 21, 2005
    from United States
    Tagamet: OTC pharmacy, same area as antacids and crap like that.

    Vitaman E and ginkgo are both avaliable as dietary supplements.

    Erythromezin? If you mean erythromycin, its an antibiotic that has to be prescribed.
     
  8. bogumil

    bogumil Gold Member

    Reputation Points:
    153
    Messages:
    395
    Joined:
    Feb 12, 2005
    Yeah, like PH said:


    Erythromizin is an antibiotic. (with this one i would be careful because if youre allergic it can become uncomfortable)


    Vitamin E you get in any supermarket or drugstore.


    The same with gingko: Drugstore, Pharmacy, Supermarket, Asia ShopsEdited by: bogumil
     
  9. intrepid

    intrepid Newbie

    Reputation Points:
    1
    Messages:
    34
    Joined:
    Feb 11, 2005
    thanks much, gotta go do some shopping before my trip this weekend.
     
  10. JewishNazi

    JewishNazi Gold Member Newbie

    Reputation Points:
    42
    Messages:
    590
    Joined:
    Feb 8, 2005
    how did your trip go?



    (sorry if its early, its what i get for being 10 hours ahead)
     
  11. Fantasian

    Fantasian Gold Member

    Reputation Points:
    1,024
    Messages:
    1,139
    Joined:
    Sep 28, 2005
    31 y/o from U.K.
    "The prescription
    antihistamine promethazine (Phenergan) helps out codeine even more"

    Does this mean all piperzine drugs or similar structures can potentiate codeine.

    For example would Cyclizine potentiate codeine?
     
  12. unico_walker

    unico_walker Newbie

    Reputation Points:
    44
    Messages:
    500
    Joined:
    Jan 25, 2005
    I would not reccomend taking an antibiotic for opiate potentiation, you'll wipe out your intestinal flora for nothing and will probably get gas and diarrhea.
     
  13. Richard_smoker

    Richard_smoker Gold Member

    Reputation Points:
    2,873
    Messages:
    1,203
    Joined:
    Sep 19, 2005
    from U.S.A.
    Bogumil said:
    Very curious... what do you mean by this statement? That all these bind to opiate receptors?? Surely that's not what you meant, is it? I've never heard of any of these being used for fun...

    Maybe they tie up liver enzymes that break down the opiates???

    I'm sensing that they will all supposedly increase an opiate experience. Is this correct? I'm very curious--anything anyone can tell me will be greatly appreciated. I've never heard of any of these being opiate potentiators. (and I have several disgruntled lab gerbils who have recently cut down their daily opiates)

    If anyone has experience with any of these, will you please post any dosages/timing and maybe the opiate that was boosted. Thanks. (and "thanks" said my gerbils in shaky, sweaty gerbil-american sign language)
     
  14. intrepid

    intrepid Newbie

    Reputation Points:
    1
    Messages:
    34
    Joined:
    Feb 11, 2005
    Been some time since SWIM last posted on this thread, but he's still interested in everyone's responses. Looking back a year ago, his experience and use of opiates has increased exponentially, and maybe even taken a turn for the worse (Nothing bad's happened yet though, hope it stays that way). But as SWIM continues to play around with opiates, and I use the term play lightly, I will continue to try and make the most with what he's got heh. SWIM's had wonderful successes with the Tagamet, and continued success with Diphenhydramine (Benadryl) and on occasion Dextromethorphan. He's yet to try out Vitamin E and Gingko, but what the hell, there's always tomorrow.

    I'll be sure to post a report for you guys when he's done. Lookin forward to the results!
     
  15. jbnugget

    jbnugget Newbie

    Reputation Points:
    0
    Messages:
    4
    Joined:
    Dec 16, 2008
    SWIM lost a colon from erythromycin Rx'd for an abscessed tooth. I had taken it many times before but, for reasons unknown, this time a reaction called psuedomembraneous colitis developed. E-mycin can cause an over-bloom of 'bad' colonic flora which gets so thick that it looks like a second membrane covering the inside of the colon. Hence, the moniker 'psuedomembraneous'.

    Thinking it was just a belly ache (E-mycin often irritates the stomach) - but THE most UNBELIEVABLE tummy ache ever - it was ignored when (after a couple hrs of sweating, shaking & puking) it went away over about a 15 minute period. BAAAD move. Tummy felt better cuz colon perforated. So full of shit, I was. For almost a day. (SWIM's usually full o' shit all the times.)

    Anyways, to shorten it for limited spans of consciousness, SWIM almost died. Permanent explosive diarrhea:eek:, surgical scars:cry: and poor nutrient absorption is E-mycin's legacy:thumbsdown:. Stick to grapefruit juice &/or Tagamet (cimetidine) as they seem to work the best - IMHO. :thumbsup: