Effects - Psilocybin-Induced Autonomic, Perceptual, and Behavioral Change (1968)

Psilocybin-induced Autonomic, Perceptual, and Behavioral Change (1968)

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    Pharmacopsychiatry, 1968, Vol.1(04), pp.291-302

    R. Fischer and Diana Warshay

    Autonomic, perceptual, and behavioral changes induced by 160 μg/kg psilocybin were studied in a homogenous sample of 15 self-selected college educated male and female volunteers. The subjects were rank ordered as to the extent of drug-induced psychopathology using their Minnesota Multiphasic Personality Inventory pre-drug to drug peak differences scores. Extent of variability on simple perceptual tasks - in gustation and vision - is significantly related to extent of drug-induced psychopathology, whereas drug-induced pupil-size increase - a reliable autonomic variable - is unrelated to drug-induced psychopathology, which, in our terminology, is equated with a subject's symbolic interpretation of his own central nervous system activity.

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