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Pharmacology - Research chemicals as cocaine substitutes (dopamine stimulants)

Discussion in 'Research Chemicals' started by Alfa, Aug 24, 2008.

  1. Alfa

    Alfa Productive Insomniac Staff Member

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    There are more and more research chemicals with a dopaminergic (affects dopamine system) effect. This type of research chemical is particularly worrisome because of the level of craving and health risks accompanied by their effect.

    At the same time they are very interesting to cocaine users.

    Please list research chemicals that affect the dopamine system, and can therefore be seen as cocaine substitutes.

    Here are some cocaine substitutes:
    Fluorotropacocaine
    Desoxypipradrol
    3-pseudotropyl,4-fluorobenzoate
    Diphenyl-2-Pyrrolidinyl-Methanol (diphenylprolinol)
    Naphthylisopropylamine
    Rti-55

    To a lesser degree the following stimulants may be interesting as well:
    Mdpv
    Methylone (mostly an ecstasy type stimulant, but does give dopamine type rewarding feeling)
     
    Last edited: Aug 24, 2008
  2. jungle

    jungle

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    what about propylhexedrine? :)

    it is not really a research chemical, but it's a dopamine stimulant too, i guess.
    as far as i know propylhexedrine is basically legal in the us.
     
  3. Alfa

    Alfa Productive Insomniac Staff Member

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    propylhexedrine is an adrenergic stimulant, not a dopaminergic stimulant. It would serve as an amphetamine substitute, not a cocaine substitute.
     
  4. AbbaZaba

    AbbaZaba Newbie

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    Methylenedioxypyrovalerone (MDPV)

    Case closed. :laugh:

    AbbaZaba added 2 Minutes and 56 Seconds later...

    Aw, swiy already listed it :(
    Eureka for a split sec at least...
     
    Last edited: Sep 1, 2008
  5. bhmoab1

    bhmoab1

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    swim would also say mdpv is pretty damn close, but not quite the rush/euphoria as cocaine. Swim would also consider it more addicting, and a drug where you want to keep doing more even moreso than coke. Although the comedown will sure make you wish you didnt keep partaking.

    Swim has found it easy to go through 100mg or more in a good run on mdpv. NOT ADVISED
     
  6. AbbaZaba

    AbbaZaba Newbie

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    Alfa:
    Since swiy hasn't gotten any new ideas yet- how about mitragynine?
    9-methoxy-corynantheidine- Its use(chewed in leaf form) was common among Thai laborers because of its stimulating quality and narcotic-like buzz. Now 15x extracts are floating around... Swiz is a bit curious about kratom himself.

    Found in a plant called Kratom as you most likely already know. One swimmer could obtain a leaf extract and perform an alcohol extraction to get mitragynine and some other alkaloids into a more potent and manageable mass. Is this possible?
     
  7. allyourbase

    allyourbase Palladium Member

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    swim can say as an occasional user of morphine meconate (natural salt) that it has stimulant properties. swim has also tried kratom, and finds this to be a commonality, including the crash afterward, though morphine's is much harder. swim thinks this has more to do with certain endorphins released by proper mu agonism than it does with dopamine, as he has also tried individually a number of k agonists and other dopamine agonists and reuptake inhibitors, and is familiar with their feeling.

    also the "crash" is entirely different. with the mu agonists its like instasleep, whereas with dopanergic compounds it is a fading "geek".
     
  8. vantranist

    vantranist Silver Member

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  9. konshuss

    konshuss Silver Member

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    Very interesting thread -- anyone have any more info?

    My cat has not tried any of the above listed RC's except MDPV, which she enjoys orally at low doses.
     
  10. NeuroChi

    NeuroChi is not his mind Staff Member

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    SWIM got a taste of a very cocaine like research chemical, but he doesn't know which one it was. The onset was faster, the rush was a little more powerful, but the euphoric effects were slightly less than cocaine. It had a psychedelic edge to it, looking at the brick sidewalk pattern in bright sunlight made it seem as though everything was vibrant and vivid.

    All from approximately 60 mg of this crystalline white powder, which looked exactly like ketamine.
     
  11. DarkDead

    DarkDead Silver Member

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    Dimethocaine seems to be one of the closest substitutes. According to Wikipedia it has both stimulant and local anesthetic proprieties in the same dose range as cocaine. Although in the Dimethocaine experiences thread SWItyranny4u reports it "feels like Cocaine light".

    Wikipedia also has an extensive list of cocaine analogues worth checking out.
     
    Last edited: Aug 7, 2009
  12. NeuroChi

    NeuroChi is not his mind Staff Member

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    I forgot to mention that the person who isn't me who tried such a substance said that it had no anesthetic properties. It must have been something else.
     
  13. DarkDead

    DarkDead Silver Member

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    As asked, here is the list of cocaine analogues (it's quite extensive):
    Source: Wikipedia
     
  14. Gradient

    Gradient Chem|EB|DMT Staff Member

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    A study utilizing WF-23 has been uploaded, entitled:

    Effects of long-term biogenic amine transporter blockade on receptor/G-protein coupling in rat brain

    A relevant passage from the discussion:

    And a few from the Results:

     
    Last edited by a moderator: Sep 10, 2010