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serotonin

Discussion in 'Magic Mushrooms (Psilocybe & Amanita)' started by markosheehan, Feb 21, 2017.

  1. markosheehan

    markosheehan Silver Member

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    is psilocin a serotonin releaser? can someone showme a source on this? im seeing conflicting reports
     
  2. Dreambird

    Dreambird Silver Member

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    What conflicting reports are you referring to? There is quite some information on this topic online (Wikipedia, NCBI...), what is it exactly that you consider inconsistent?

    On Wikipedia you'll find the following paragraph (under "psilocybin")


    Based on this, I would say no, neither psilocybin nor psilocin is a serotonin releaser. They just act similar to serotonin and bind to some of the same receptors. If you're aware of sources that say otherwise, you're welcome to share them so we can have a look at them and keep on discussing.
     
  3. markosheehan

    markosheehan Silver Member

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    It just says it mimics it. It does not say anything about increasing or decreasing serotonin levels. Are you just assuming this
     
  4. markosheehan

    markosheehan Silver Member

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  5. Dreambird

    Dreambird Silver Member

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    Yes, I am assuming it. As well as I'm assuming that psilocin doesn't cause fingernails to grow and eyes to pop out. The effect you are referring to isn't mentioned in the sources I checked, so I assume it doesn't exist.

    Plus, there is a list of monoamine releasing agents (MRAs) on Wikipedia (under "Monoamine_releasing_agent"). Monoamines are neurotransmitters, they include serotonin. Psilocin is not among the MRAs:



    If you are still in doubt and refer to "conflicting reports", please name them.
     
  6. markosheehan

    markosheehan Silver Member

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    It says in what I linked extracellular 5ht levels slightly increased in the medial prefrontal cortex.

    Also psilocin has affinity for SERT even though it is small
     
  7. Dreambird

    Dreambird Silver Member

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    Okay, I see what you're saying.

    The study you're quoting basically found, that the administration of a relatively high dose of psilocin increases the serotonin level in the brains of rats.

    That's nice and all, and it might lead to the hypothesis that psilocin does the same in humans.
    But so far, that's all it is, a hypothesis. I'm not aware of clinical evidence that supports this idea. However I'd agree if you proposed further investigation.

    Serotonin affects different creatures in different ways. Some plants use it as a poison, in monkeys it controls dominance behavior, in other animals it's associated with hunger (source: Wikipedia, "Serotonin"). So I'd be cautious to presume that psilocin has the same effect on the serotonin levels in humans as it has in rats. Especially as no pharmacological description I could find mentioned such an effect.
     
  8. markosheehan

    markosheehan Silver Member

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  9. Dreambird

    Dreambird Silver Member

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    The study shows, that psilocin has an affinity for SERT, agreed.

    SERT stands for serotonin transporter. It's a protein that is relevant for the (re)uptake of serotonin. (source: Wikipedia, "Serotonin_transporter")

    If a substance has an affinity for this protein, it means that this substance will bind to it with a certain strength. The higher the affinity, the less of the substance you need to occupy the binding sites. (source: Wikipedia, "Ligand_(biochemistry)")

    But could you please explain why serotonin release should be affected if a substance binds to the SERT protein? After all, that's what the question was initially about.
    It seems feasible that psilocin might have an effect on the serotonin uptake and subsequently perhaps on the serotonin level. It's still a hypothesis, but it could be possible. Yet, I don't see how serotonin release is influenced by this.