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Snorting methadone

Discussion in 'Methadone' started by Ellis D., Jan 30, 2007.

  1. Ellis D.

    Ellis D. Newbie

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    SWIM was wondering if methadone is effective when snorted?

    -thanks
     
  2. CrookedEye

    CrookedEye Palladium Member

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    Not any more so than when eaten. Methadone doesn't provide a rush, at all, so no point in snorting it..
     
  3. Forthesevenlakes

    Forthesevenlakes

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    Methadone is only "moderately" soluble in water according to its MSDS, and its oral bioavailability is up to 80%, so it probably wouldnt be much more effective if snorted. 80% bioavailability is pretty darn good for a drug taken orally. SWIM would say that methadone has so much chalky material in the wafers anyway that it would be quite unpleasant to insufflate. Like crookedeye says, its probably best to take it as directed...down the hatch and into the stomach.
     
  4. ZepDoorsFloyd41

    ZepDoorsFloyd41

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    Methadone seems to have a bunch of fillers and waxes and what not, and when SWIM snorted it, it really stuffed up his nose times 10. It wasn't too fun. SWIY should chew it, or parachute it. Parachuting is where SWIY breaks it up into a fine powder, wraps a thin peice of tissue around it into a small ball, and just swallows that. The thin paper will break open very quickly since its so thin, and then the powder will hit SWIY faster. Same thing as basically chewing it, just less gross. :cool:
     
  5. Benzeneringz

    Benzeneringz Titanium Member

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    SWIM snorted 10 mg's of methadone one time and it burnt like meth. Effects were just not present. He ended up eating 20 milligrams and felt a significant effect. Snorting methadone doesn't do anything and is a waste of such a bioavailable and wonderous drug.
     
  6. Ellis D.

    Ellis D. Newbie

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    Thanks mucho gusto for the informacion. You all know your sh**. SWIM is farmiliar with the methadone burn, and snorting arpox. 7.5mg noticed something but of placebo? hard to say... SWIM wanted to get some other opinions so thanks for the in-put.

    SWIM and I ( iused to have a script) both happen to agree that that methadeon is just as effective if not much more when taken orally rather than insulfated.

    SWIM and I actually notice/d a decent amount of "wellbeing" from methadone, nothing significant to H but still something opiod. Like it's cousins it for swim still has it's blanket of opioid warmth for swim to look forwards too.

    Hope everyone is chillin smoothly

    -Peace
     
  7. Benzeneringz

    Benzeneringz Titanium Member

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    I don't think the 7.5 mgs SWIY insufflated was placebo. I mean, snorting methadone is a waste but that doesn't mean nothing gets absorbed into the bloodstream. It's just that swallowing them will put more into your veins.
     
  8. Gaius315

    Gaius315 Silver Member

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    SWIM snorts methadone frequently because snorting is part of SWIMs addiction (like holding a cigarette for smokers.) SWIM can't tell a difference between taking and snorting, and snorting burns like hell.
     
  9. Orchid_Suspiria

    Orchid_Suspiria

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    Methadone can definitely be snorted and it will have about the same effects as ingesting it orally,however as people have said it will burn and probably make you sneeze thus you will lose alot of the methadone in the process.
     
  10. Griffin

    Griffin Newbie

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    SWiM thought this was interesting, especially as SWiM thought SWiM was ingesting LESS instead of MORE. Now SWiM is up to 45 mg. and is getting scared as it's been 2 months. SWiM wonders if detoxing will be difficult. SWiM was changed from oxycontin to Methadone for chronic pain and methadone works TOO good in SWiM's opinion and SWiM is scared of it, but the doctor prefers rxing Methadone to other opiates for pain even though the half-life is longer. SWiM told SWim's doctor that Methadone is scary because SWiM is hoping that the injections will work and SWiM will not have to take opiates anymore, but SWiM thinks that once on methadone the brain will need opiates forever or be very depressed. What does SWiY think?

    SWiM is new on this forum.

    Griffin added 0 Minutes and 36 Seconds later...

    Here is the abstract SWiM was mentioning above:

    OBJECTIVE: Nasal administration of many opioids demonstrates rapid uptake and fast onset of action. Nasal administration may be an alternative to intravenous and oral administration of methadone and was therefore studied in human volunteers. METHODS: The study was approved by the Institutional Review Board of the University of Washington, Seattle. Eight healthy volunteers (6 men and 2 women) aged 19 to 33 years were enrolled after informed written consent was obtained. Subjects received 10 mg methadone hydrochloride nasally, orally, or intravenously on 3 separate occasions in a crossover design. Nasal methadone (50 mg/mL in aqueous solution) was given as a 100-microL spray in each nostril (Pfeiffer BiDose sprayer). Blood samples for liquid chromatography-mass spectrometry analyses of methadone and the metabolite 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolinium were drawn for up to 96 hours. The methadone effect was measured by noninvasive infrared pupilometry coincident with blood sampling. RESULTS: Nasal uptake of methadone was rapid, with maximum plasma concentrations occurring within 7 minutes. The maximum effects of intravenous, nasal, and oral methadone, on the basis of dark-adapted pupil diameter, were reached in about 15 minutes, 30 minutes, and 2 hours, respectively. The respective durations were 24, 10, and 8 hours. Both nasal and oral bioavailabilities were 0.85. Subjects reported that nasal methadone caused a burning sensation. CONCLUSIONS: Nasal administration of methadone results in rapid absorption and onset of effect and high bioavailability, which was greater than that reported for other nasal opioids, with a similar duration of effect. Nasal administration may be an alternative route of methadone administration; however, improved formulations are desirable to reduce nasal irritation.
     
    Last edited: Mar 30, 2009
  11. orballa22

    orballa22 Newbie

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    do not snort it, swim has done it before and it feels like pop rocks in the nose. not fun and makes swim sneeze like 30 times in a row..:(
     
  12. EyesOfTheWorld

    EyesOfTheWorld R.I.P.

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    Snorting methadone is horrifically painful and SWIY will either puke or sneeze it all out or both. Take it from a guy who has abused every opiate on the fucking planet in almost every possible way. Oh, and there's no increase in high, should swiy manage to keep it down.
     
  13. electros[h]ock_patient

    electros[h]ock_patient Silver Member

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    Sorry, but swim has direct personal experience that challenges the old "methadone doesn't provide a rush, at all" notion (in respect to intravenous use anyway).

    Swim understands its good practice to tell people to avoid diversion of methadone for their own safety and what not...especially in the case of insufflation here. It just so happens that Eye has gone one further. Swim would consider drug intake a science with rigid laws, then again, does the metabolic system allow for variation in "different" people, because swim just don't understand the common "misconception".

    Any bright people with qualifications, or even those with dubious but distinguished informal backgrounds care to weigh in?
     
  14. Nil by Mouth

    Nil by Mouth Silver Member

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    Can SWIM add that a Friend of a friend smoked (chased) some pure methadone powder and almost over-dosed on it(the ambulance was not called but nearly!)
    SWIM may add that while she was a heroin user she was at the early stages of addiction and was still 'dabbling' quite a bit.
     
  15. fro069

    fro069 Newbie

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    when swim snorted a done once it was worse than any meth or anything ever swims eyeball felt like it was gonna pop out n swims nose n throat burned like swim snorted salt
     
  16. LegalizeSpiritualDiscovry

    LegalizeSpiritualDiscovry Newbie

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    Snorting it burns because, as far as I recall, methadone is mixed with pure sand so that you a can't shoot it (at least not the crushed up pills) and snorting it burns and can cause nosebleeds. I've never gotten nosebleeds on it, but I've only snorted up to 15mg at a time. I would usually get my shower running, snort it, and then run in the shower and drink from a glass of water and gargle shower water until it stopped burning, which only took about 5 minutes. Hits you while it's still burning. By the time the burning's gone, you already feel really good.

    Back then, I used to do that and then do my thang in the shower, and when you bust a nut, you feel like twice as high afterward.
     
  17. Helene

    Helene Gold Member

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    Some methadone tablets do contain silicon dioxide, which I assume is what you mean by "pure sand". This seems to be more the case in the US, rather than in the UK - unsure of the situation in the rest of the world.

    Some ingredients lists -

    Generic Methadone HCl tablets:
    Active ingredient: methadone hydrochloride USP
    Inactive ingredients: lactose monohydrate, magnesium stearate, microcrystalline cellulose and
    silicon dioxide.

    Physeptone® Methadone tablets:
    Active ingredient: methadone hydrochloride
    Inactive ingredients: gelatin, glycerol, lactose, maize starch and magnesium stearate.

    Dolophine® Methadone tablets:
    Active ingredient: methadone hydrochloride
    Inactive ingredients: magnesium stearate, microcrystalline cellulose, and starch.

    Diskets® Dispersable Methadone Tablets for Oral Suspension ("wafers"):
    Active ingredient: methadone hydrochloride
    Inactive ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, orange lake color, orange-pineapple flavor, potassium phosphate monobasic, pregelatinized starch, and stearic acid.

    Methadose® Dispersible Tablets for Oral Suspension ("wafers"):
    Active ingredient: methadone hydrochloride
    Inactive ingredients: dibasic calcium phosphate, microcrystalline cellulose, magnesium stearate, colloidal silicon dioxide, pregelatinized starch, stearic acid.

    Generic Methadone Dispersible Tablets for Oral Suspension - orange flavoured ("wafers"):
    Active ingedient: methadone hydrochloride
    Inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, magnesium stearate, microcrystalline cellulose, pregelatinized starch, stearic acid, orange blend: FD&C yellow #6, FD&C yellow #6 lake, and FD&C yellow #5 lake, orange flavor.

    H
     
  18. Los_Daddy_Dollas

    Los_Daddy_Dollas Newbie

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    Snorting the tablets works just as good as eating but quicker, but it feels like u snorted ammonia!! If your taking just 1 7.5 thats why you didn't feel much cuz, up the dosage and keep the swag on!
     
  19. Helene

    Helene Gold Member

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    This is extremely dangerous advice. As little as 20mg of methadone can kill a non-tolerant adult. And there are many reported cases of this happening.

    H
     
  20. ebrownieboy

    ebrownieboy Newbie

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    I need help. I used (snorted) meth for the first time three days ago with a co worker believe or not. I will never do that stuff again. But strange things are happening to my body. First off I feel very very tired; so tired that I just want to go to sleep within minutes or even seconds. I sleep all day and still be sleepy. My equilibrium is off; I think my brain is like fried or something. I'm a analyst and still can do work but I can only focus for so long before I get sleepy and start going dumb. I get dizzy and everyone can see how tired and stressed I look in my face. Someone please help me to understand what is happening to me and will I recover soon? I hope I'm not dying or brain dumb. I will never do that stuff again.