In the rare instance that anyone happens to be on/starting SNRIs (Antidepressants) and using AM-2201, I advise monitoring your physical health carefully! A friend of mine recently started taking SNRI and has found that the two in combination can absolutely destroy your appetite. He was eating no more than one meal per day for three days because his stomach wouldn't accept any food. He would go out to eat, feeling strong hunger pains, but when he put food in his mouth his stomach would turn to rock. These effects appear to have petered off after a full 24 hours of abstaining from AM-2201, but I will report back to see if it happens again to him. His usage was a total of about 60-100mg of blend per day and occasionally mixes in 3-6mg of the pure chemical ordered from a trusted vendor. The dosage of SNRI is 37.5mg of Effexor (Venlafaxine) per day. The Effexor is taken at the start of the day and my friend typically doesn't consume AM-2201 until the late evening. I figured I'd drop this message here.