I takes 20mg Percocet/oxy three times a day for pain. SWIM noticed from the first day that oxy was working oddly and gave little help to pain and no buzz. After months of use SWIM tapered off an SNRI, and exactly 24hrs after last SNRI dose oxy effect went up so high at usual dose of 20mg that SWIM almost freaked out! Then same exact story with a tricyclic! Is this possible? It doesn't say anywhere that antidepressants and opiods interact (maybe only Tramadol as it is an SSRI partly, but not oxy!