I have been taking zoloft for a long time.. cant even remember how long. The only drugs that can really fuck swim up are weed and liquor. I am switching his SSRI to an SNRI, effexor. Before, there were many drugs I could not touch, such as DXM and kanna, as well as a number of drugs that would have NO effect on him, no matter the dose, including xanax, oxycodone, hydrocodone, codeine, and ambien to name a few. I will be going from a relatively high dose in terms of SSRI's to a low dose in terms of SNRI's (150 mg sertraline to 75 mg effexor). Does anybody have any information on the effects of mixing SNRI's with things such as dxm (especially), amphetamines (dextro-amphetamine), and other fun little pills? Should these pills such as d-amphetamine, percocet, and ambien be stronger now with a lower dose and on SNRI? and also, would SWIM be safe taking a seretonin affecting drug such as tramadol or dxm on his new SNRI?