During opiate withdrawal I loose all my energy. I have no power and it is hard to stand up and go for a walk or do something else. Drinking a cup of coffee did not help me last time. But at that time was used to lots of coffee. Because I drank so much coffee at this time, one cup of coffee did not help me with tiredness anymore. So it was not surprising that I one or two cups of coffee gave me not more energy during withdrawal. Now it's a long time ago since I last drank coffee. I nearly drank no coffee for more than two years. When I now would drink a cup, I probably will feel more awake. I thought that I maybe could help with tiredness/fatigue when I will start drinking coffee during withdrawal again. But I read that stimulants would make everthing worse during withdrawal. So I started my reasearch. In the follwing clinical study some addicts took some non-opioid drugs and should rate how it helped during opiate withdrawal or if it made symptoms worse. Most of that stuff did not help. Cocaine didn't help, amphetamines not and caffeine either not. No reduction of opioid withdrawal. A worsening of opioid withdrawal was reported by 62% of the patients for cocaine, 62% for amphetamine, 50% for caffeine. Derik Hermann, Eckard Klages, Helga Welzel, Karl Mann, Bernhard Croissant. Low efficacy of non-opioid drugs in opioid withdrawal symptoms. Addiction Biology Volume 10, Issue 2, pages 165–169, June 2005 But then - otherwise - I read in some internet forums that use of amphetamine, methamphetamine, ritalin, adderall, ... helped some people during withdrawal. I also read that it helped some people to get through the PAWS but that's another story... There are Traditional Chinese Medicine capsules for opiate detox. It's a herbal formula and it seems really to have positive effect on withdrawal. That stuff helped some people to kick opiates. I never took those capsules but I followed some internet forum discussions. One of the herbal ingredients is Ephedra sinica. There are only 5% of this herb in the capsules. So it is not much. The capsules seem to help but maybe it's the other ingredients and it is just too less ephedra to to anything... I don't want to imagine the comedown from a cocaine injection or XTC pills or methamphetamine while being on opiate withdrawal. This surely won't be funny. But maybe some cups of coffee or a cup of ephedra tea (or some ephedra pills) or some guarana capsules could give a little more energy. There will probably be no problems with coming down. But the other thing is, that most stimulants increase neurotransmitter levels in the brain (serotonin, dopamine, norepinephrine). As I have read, dopamine agonists (e.g. L-Dopa plus decarboxylase inhibitor or apomorphine) shall help with opiate withdrawal. Serotonin supplements also are said to help. I wasn't able to find clinical/medical/scientific studies whether ephedrine helps or worsens opiate withdrawal symptoms. Same case with (meth)amphetamines, MDMA or something similar. Because of the legal status of those chemicals/drugs it is not surprisingly that I cannot find any studies about that. But what about ephedra (which is in most countries just a usual prescription drug) or caffeine? Everything I found was a little ... strange ... Some people told it would help, while other texts say: don't use during withdrawal. Any experiences? Or better any medical knowledge? Links to clinical studies?