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Opinions - Strongest ADHD medication? (Desoxyn not included)

Discussion in 'Amphetamine' started by Gimpy, Jul 2, 2013.

  1. Gimpy

    Gimpy Silver Member

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    For those who have been through lots of ADHD medication, which of these do you think is the strongest- meaning most focus, euphoria, and energy? Lets say 10mg each.

    Adderall
    Ritalin
    Focalin
    Vyvance
    Dexedrine
    Strattera
    Vivalan

    Obviously Desoxyn (dextromethamphetamine) would be the strongest, so I'm leaving it out.

    Thanks for your opinions.

    Gimpy added 3 Minutes and 1 Seconds later...

    Edit: If you're able to put them in order from weakest to strongest, that would be nice.
     
    Last edited: Jul 2, 2013
  2. synx

    synx Newbie

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    1. *smack!* "shut up and study!"
     
    Last edited by a moderator: Sep 10, 2017
  3. baselined

    baselined Titanium Member

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    Any particular reason that it has to be 10mgs of each?

    For instance, I think Vyvanse rocks, but 10 mgs of vyvanse would produce little if any noticeable effects. If I remember correctly I think vyvanse is about half a potent as adderall. But given 10 mgs of adderall versus an equivalent dose of vyvanse at 20mgs, I think I would take the vyvanse (feels less jittery to me).

    Out of all of those though, I think focalin is my favorite. It gave me a long lasting, intensely euphoric high, comparable to cocaine. Although I didn't experience as much jaw tension as I would cocaine.

    My top three (in order) are: Focalin, Dexedrine, Vyvanse
     
  4. Booty love

    Booty love Silver Member

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    To get a proper opinion on these meds, even with desoxyn in the mix, you can't limit it to 10mg. You maybe can split the extended release and instant release meds into separate catagories and do 10mg.

    As you have it right now, i would say 10mg of dexidrine wins the race. Dexidrine only comes in 5mg and 10mg ir's and have half lifes of 10-12 hrs and an oral bio of 75%

    Focalin and ritalin also come in 5 /10mg ir's but both have half lifes of 4 hours.
    Oral bio 11-52%
    Statterra isnt a narcotic so i dont think it should be in the running and vivalan is for depression.

    Desoxyn only comes in 5mg pills and has a half life of 9-12 hrs oral bio 62%

    Adderall which i think is your overall best bet for strongest, only because it comes in 30mg ir's and i think i 30mg adderall ir is stronger than a 10mg dexi and a 5mg desoxyn. Adderall also has a 9-12hr half life. Something around 30% bioavailabilty oral.

    Per mg i would say 1- dexi 2- focalin 3- adderall 4- ritalin. In my opinion i don't like XR pills but i would rate them the same.
     
    Last edited: Jan 15, 2014
  5. JTC3889

    JTC3889 Silver Member

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    Of that list Dexedrine is the most potent and definitely the strongest. Omitting Desoxyn that is.
     
  6. DiabolicScheme

    DiabolicScheme Titanium Member

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    The strongest medication doesnt mean the best for ADHD if that is what you are looking for.

    Stimulants cant over stimulate and cause a bigger distraction by causing anxiety/panic attacks; depending on your metabolism and sensitivity to these drugs.

    Adderall is probably the 'strongest' as it is a mixed form of amphetamine salts were Dexedrine is just dextroamphetamine, but the again some respond to certain medications better.

    So stronger to me may be weaker for you. I too would like to know what the 10 mg limit is for? If this accounted for then I would believe dexedrine to be the strongest since the clinical doses are less than the others.
     
  7. JTC3889

    JTC3889 Silver Member

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    Dexedrine is more potent as dextroamphetamine is more potent than mixed salts because levophetamine is in adderall which has a lower potency and has negligable effect on the CNS. It is only 3/4 dextroamphetamine while Dexedrine is 100% dextroamphetamine.
     
  8. triplexm

    triplexm Silver Member

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    If you're looking at which med provides the most focus, the most euphoria and the most energy, I don't think there really is one answer (or one drug that wins on all counts). And like others have already said, 10mg is not an equivalent dose across the board and you'd have to take that into account.

    Although Dexedrine definitely beats the rest hands down in terms of euphoria, I think it loses on both the focus and energy counts. Personally, I think Vyvanse is best for providing intense focus and ability to concentrate. And thanks to the otherwise totally unhelpful levophetamine in it, Adderall definitely has the strongest kick. Pure dextroamphetamine just doesn't give you that same rush of energy (...or the accompanying jitteriness). I think Adderall is probably the 'strongest' ADHD med after Dexoyn, taking into account all the factors you mentioned and assuming they're all of equal importance.

    Anyway, it goes without saying that everyone has their own set of preferences about what they want a medication to provide and what factors are most important to them.
     
    Last edited: Jul 4, 2013
  9. baselined

    baselined Titanium Member

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    I would agree with you there. I probably actually do like adderall just as much as dexedrine (my number 2), but sometimes the jitters can be over powering if you start lacking something to burn all the energy on.

    Although a BILLION times more useless than levoamphetamine is levomethylphenidate. If I am not mistaken, your liver favors the levo isomer versus the dextro, in terms of drugs like ritalin.

    Regular methylphenidate (ritalin) is by far my least favorite stimulant. The levo isomer just gives my body crazy side-effects without an equally potent and accompanying euphoria. Dexmethylphenidate, however, is pretty awesome; great euphoria. Although it has been some time since I have had the pleasure of indulging in that ;)
     
  10. Jealsi

    Jealsi Newbie

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    I've been on all of these for at least 3 months each, except Vivalan, and for euphoria I'd order them as:
    • Dexedrine
    • Adderall IR
    • Focalin IR
    • Ritalin
    • Strattera/Vyvanse
    As far as attention and energy boost, I'd order them as:
    • Adderall IR
    • Focalin IR
    • Dexedrine
    • Ritalin
    • Strattera/Vyvanse
    Of course this is subjective and varies considerably between different people. Strattera and Vyvanse both do absolutely nothing for me, so they're tied for last place. Considering all three factors, I'd say Adderall IR is best overall for me, few side effects compared to Ritalin. To me, Adderall IR is the go to, but if I am looking for a euphoric experience, I'll go with Dexedrine.
     
  11. SwampFox56

    SwampFox56 Newbie

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    I'll be honest. I found Desoxyn (Methamphetamine) be rather disappointing in terms of stimulation. It was definitely the most euphoric of all the prescription stimulants, but I expected it to be MUCH stronger than the other prescription stimulants.

    I found that a 5MG's dose of Adderall (for instance) was much more stimulating than 5MG's of Desoxyn.

    Just so you know, Strattera and Vyvanse are two different drugs. Strattera is Atomoxetine; which is a Norepinephrine reuptake inhibitor. Vyvanse is an actual Amphetamine (Lisdexamphetamine) and is actually metabolized in vivo into Dextroamphetamine.
     
  12. Jealsi

    Jealsi Newbie

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    I'm aware, I've been on both, I should have put it a different way. What I meant was, those two are on the same "level" and provided absolutely no benefit to me at all. Wasn't surprising with the Strattera, but I was a bit surprised Vyvanse didn't do a thing for me considering my favorite for euphoria is Dexedrine. Thanks for pointing it out though, I guess I didn't explain well enough.
     
  13. Smeegal

    Smeegal Newbie

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    Haven't seen a few of them in my travels so I'll go with what I have seen.

    1.Vyvanse (wicked intense)
    2. Ritalin
    3. Adderall
    4..Focalin

    All are pretty similar, vyvanse to me hit u harder and longer
     
  14. SwampFox56

    SwampFox56 Newbie

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    ...Vyvanse wicked intense? I think it probably wasn't Vyvanse lol. Dexedrine maybe? As for the rest, Adderall is most everyone's go to amp. Adderall gives HUGE stimulation, while also providing a love for music that is rarely matched by other drugs.

    As for Ritalin and Focalin - I've taken 30MG Ritalin before and thought it was subpar. Not even close to Adderall in terms of euphoric effeccts. Focalin was a bit better, and maybe even matched the lesser amps (Vyvanse, and Dextrostat) but it still has it's own issues. It lasted for literally 30 minutes, then was over.
     
  15. triplexm

    triplexm Silver Member

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    At higher doses (80mg+ I'd say), Vyvanse can definitely provide a very, very intense high. It may take longer to kick in than Adderall, but once it starts to hit you, it hits you hard. The first time I took it - at perhaps the rather excessive dose of 180mg - I remember how all at once it just smacked me in the face. In no way was I prepared for the high - I've tweaked harder on Vyvanse than I ever have on crystal meth. The duration of the high too is pretty insane. Adderall is definitely stronger mg to mg (I think to get an equivalent dose of Vyvanse, it's basically double) but Vyvanse isn't what I'd call a 'lesser' amphetamine.
     
  16. Gimpy

    Gimpy Silver Member

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    Thanks for the replies DF'ers! I hadn't checked this thread in a while so I decided to come back to it. For my ADHD, my doctor prescribed Vyvanse 50mg. I like the long-lasting and smooth up and down, a couple of you mentioned it and I believe it was the right choice. So thanks again :)
     
  17. staples

    staples Gold Member

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    Please use (or at least include) generic names as this is an international forum and the brand names differ from country to country or may not even be available in all countries. Vivalan appears to be Viloxazine, which doesn't appear to be marketed in the United States, nor does it appear to be approved for the treatment of AD(H)D and that doesn't even appear to be an off-label use... Not sure where that one came from??

    Also, I thought Desoxyn is racemic methamphetamine... isn't it? I suppose it woulnd't matter since the levorotary enantiomer has limited physiological effects besides vasoconstriction, so it is sold over-the-counter as a decongestant, anyway. But for the sake of information accuracy, could anyone confirm that the formulation desoxyn is racemic methamphetamine or just the dextrorotary enantiomer?

    I have to agree with others that the fixed dose doesn't make a lot of sense

    Euphoria and general energy should not be factors when looking to treat ADHD. Relative strength is fair, but probably of little relevance to one's individual therapy.

    I've tried all the ones approved for ADHD treatment listed in the OP except atomoxetine (Straterra). While I was seeing an ADHD specialist, I did ask about atomoxetine, wondering why it would work given what (admittedly little) I understood about it. To my curiosity I received a quick reply: "It doesn't" which made me laugh. Of course she was being brief, certainly some people do find it effective, but in general, it's not a great option.

    Within the therapeutic range, 'strongest' is subjective, but this is how I'd rank them:
    • Dextroamphetamine (Dexedrine)
    • Lisdexamfetamine (Vyvanse)
    • Mixed Amphetamine Salts (Adderall)
    • Dexmethylphenidate (Focalin)
    • Methylphenidate (Ritalin)

    When comparing a fixed dose, the lisdexamfetamine, unfairly weighted by the levolysine component, would have to drop at least bellow M. Amphetamine Salts, maybe (and this is a big maybe if you ask me) even bellow Dexmethylphenidate.

    Interesting... Because of the prodrug design, the bioactivation process, and the fact that lisdexamfetamine does not accumulate in the body, the abuse-liability studies for lisdexamfetamine have shown that the effects are attenuated at around 150mg--taking more is a waste, and the subject would pee out a considerable amount of unactiveated lisdexamfetamine... Not sure why your experience was so different, perhaps other factors can prevent elimintation of LDX?
     
  18. Gimpy

    Gimpy Silver Member

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    Sorry staples, you're right. I was a newbie when I first started this thread. I didn't know if the generic names needed to be included when I joined DF.
     
  19. scartissue_68

    scartissue_68 Palladium Member

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    I'm sure you meant the "euphoric high" felt like Cocaine, but we all know, even good Coke wears off in 20-30 minutes or so and the best euphoria might last only 10 minutes. Also, all these numbers are for relatively Coke naive users. The longer you use, the quicker your back on the mirror.

    Sorry to be so specific, but I hate Cocaine. I don't want some Newbie thinking Coke lasts a long time.

    My point might be slightly off-topic, but then duration of euphoria would seem to be part of the the answer to OP's question.
     
  20. Gimpy

    Gimpy Silver Member

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    Yes the duration of euphoria was kind of what I wanted to know, so thank you for that. I do know that cocaine lasts for a very short period of time. It would be understandable though that not the duration, but that the "high" itself from Focalin (dexmethylphenidate) is comparable to coke. I've heard that Ritalin (methylphenidate) is VERY comparable to coke when it's abused, even when it comes to the duration. Since Focalin is a chemical variant of Ritalin; what he's saying kind of makes sense.