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STUDY: monoamine transmission effects of various chemicals

Discussion in 'Research Chemicals' started by radiometer, Dec 20, 2006.

  1. radiometer

    radiometer bananadine addict Platinum Member & Advisor

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    I found this posted elsewhere today. This will be published in the European Journal of Pharmacology. It would be fantastic if comeone could come up with the full text of this study:

    The person who originally posted this apparently had access to the full article, and included the researchers' conclusion:

     
    Last edited: Dec 20, 2006
  2. Nagognog2

    Nagognog2 Newbie

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    Excellent find. This backs many of my findings perfectly. Please post the full article - anyone - if you can find it.
     
    Last edited: Dec 21, 2006
  3. Alfa

    Alfa Productive Insomniac Staff Member

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    That article is hard to find, but would be very nice to have.
     
  4. nanobrain

    nanobrain Platinum Member

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    as if there was any doubt, eh gang?
     
  5. Rush

    Rush Titanium Member

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    yeah, finally i see some pharmachology research about 5-meo-amt!

    how to find old articles that are not online? is there some way? at least abstract because there isnt even that!

    i'm interested in
    Synthesis and some pharmacological properties of alpha-methyltryptamine and its 5-methoxy derivative.

    TERZIAN AG
    SAFRASBEKIAN RR
    SUKASIAN RS
    TATEVOSIAN GT

    and also very important to me:
    Kantor RE, Dudlettes SD, Shulgin AT.

    5-methoxy-alpha-methyltryptamine (alphs, o-dimethylserotonin), a hallucinogenic homolog of serotonin.
    Biol Psychiatry. 1980 Apr;15(2):349-52. No abstract available.
    PMID: 7417623 [PubMed - indexed for MEDLINE]

    thank you for every help!
     
  6. Alfa

    Alfa Productive Insomniac Staff Member

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  7. London_Bloke

    London_Bloke Gold Member

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    Good find - I'd really like to see the whole thing...
     
  8. NeonCortex

    NeonCortex Newbie

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    It's uploaded under "Research Chemicals".
     
  9. radiometer

    radiometer bananadine addict Platinum Member & Advisor

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    You've got me excited! But I'm a dolt and can't find it - can you please link to it? Thanks.
     
  10. Alfa

    Alfa Productive Insomniac Staff Member

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  11. El Calico Loco

    El Calico Loco Newbie

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    Pardon my amateurness, but I want to make sure I understand:

    The 2C's are mild dopamine, serotonin, and norepinephrine releasers and reuptake imhibitors, while 5-MeO-DMT is a weak releaser but a somewhat stronger reuptake inhibitor?

    Do MAOIs work the same way? I thought (for whatever reason) that the action of MAOIs took place in the GI tract rather than the brain, preventing things from getting digested properly (or causing other things to get digested the way you want them to).

    I suppose this says something about the use of tobacco and DXM with these RC's...tobacco smoke inhibits the reputake of dopamine, IIRC. DXM supposedly inhibits both dopamine and serotonin.


    ECL
     
  12. Alfa

    Alfa Productive Insomniac Staff Member

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    MAOI's are something different but related. MAOI's inhibit the oxidating of the mono amines mentioned above(dopamine, serotonin, and norepinephrine). In other words: MAOI's potentiate mono amines.
    And yes, mono amines are present in the GI tract. But mono amines are not limited to the Brain.
     
  13. pankreeas

    pankreeas Gold Member

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    so by potentiating do you mean maoi's aid in getting mono amines across the blood/brain barrier at a faster rate? and this is a negative thing?
     
  14. Alfa

    Alfa Productive Insomniac Staff Member

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    I mean that where part of the available mono amines would normally be oxidated, with the activity of MAOI's less mono amines get oxidated and thus more mono amines can affect the body.
     
  15. El Calico Loco

    El Calico Loco Newbie

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    So...5-MeO-AMT strongly inhibits reuptake while encouraging release at the same time. Could this be why some people have such an adverse reaction to it? Self-induced serotonin syndrome, perhaps? While others who have too little serotonin to begin with (naturally, or because they've been using too many drugs lately) have no such reaction?


    ECL