Over the past three weeks I have been taking 10 mg of memantine daily. Since I have started doing this, all my Kratom has more of a stimulant edge. There is not a ton of added jitteriness or anxiety, but rather the get and go effects of each strain are more prominent. Used to when I took 2.5 grams of a slow strain I would feel really chill and mellow. Now when I take this dose, I have the urge to physically get up and get my body moving and exercise, do yard work, etc. When I decide to go up 5 grams for more sedating effects, the effects are even stronger than they use to be. I get a lot more sedation than I used to, but my legs get weak feeling, I get sleepy, I get nauseous, and I start itching a lot. If you want stronger effects from your kratom, or you need to reduce your tolerance, I recommend memantine.