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Experiences - Tapentadol

Discussion in 'Opiates & Opioids' started by honourableone, Aug 3, 2009.

  1. honourableone

    honourableone R.I.P. Gold Member

    Reputation Points:
    May 29, 2008
    Please add your experiences with Tapentadol. Please add dosage, route and duration to the top of your post like this:

    When posting a experience, please describe:

    • body weight & gender
    • dose taken
    • route of administration
    • Setting: in what environment it was taken.
    • duration of main effects
    • main effects
    • side effects
    • after effects
    • rating of the experience
    • addictive qualities / abuse potential
    • any other valuable information
    Info about this drug (other than experiences) should be discussed here: Tapentadol Drug Info
  2. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    New Drug Nucynta(Tapentadol)

    Swim says:

    Anyone have any reports on this drug yet? Scouring the web i see alot of mixed reviews. Alot of people are being switched over by their pain doctors to this new opiate. Its apparently a unique molecular structure. I have a script of 90 mg pills from my pain doctor. I have to come off percoset because I was getting addicted to them and I'm suffering some nasty withdrawals now. Hopefully over in a few days.

    Once my withdrawal is over and I am at baseline again I am going to try it. My brother might try it tonight so hopefully I can post some info tomorrow.

    It seems most people coming from percosets or other narcotics arent liking it that much and complaining their pain is bad. My opinion on that is they are most likely withdrawing from their narcotics as they stop taking them when switching to nucynta. Some of the people who seem fairly new to opiates say its a strong drug but energizing and it takes away alot of pain including nerve pain. Its a schedule II drug so in theory its got high abuse potential and also the ceiling is VERY high in doses...I believe it says the max recommended is 600 mg. In trials that ive read, they compared 100 mg nucynta to 10 mg oxy and 60 mg Morphine sulfate and said analgesic effect was similar. No reports on eurphoric effects.

    So hopefully this won't be as addicting for me as the friggin oxy's.

    Please post experiences here and I will be sure to post mine.

    Last edited by a moderator: Jan 22, 2010
  3. 3dfunk

    3dfunk Mercury Member

    Reputation Points:
    Nov 26, 2008
    Male from U.S.A.
    Re: New Drug Nucynta(Tapentadol)

    My friend, Chuck was prescribed mucynta 50mg. yesterday after several months of taking Perc 10/325. He said they were similar to Percs in that they are for fast-acting situations. He also prescribe another drug called Avinza 30mg...those are the long lasting kind, morphine in there somewhere.

    Chuck took 2 Mucynta's about 1pm. At 9:30pm, I was still in a lot of pain and doubled the dose taking four, or 200mg.

    Within minutes, Chuck said that he felt awful! Very dizzy, very lightheaded but most of all, a very vivid sence of not being in the room. Chuck would do something and 2 seconds later, Chuck said he was questioning if he'd done it in the first place. Couldn't remember some of the things he had said and would come out of conversations feeling completely out of the loop.

    NOT a pleasent experience. Chuch has had problems with lots of the codeine alternatives. Soboxine made him throw up for the first time in 30 years. The fentanil patch was a bit over the top...never could find an happy medium. Ultimately ended up taking Methadone for the past three weeks. Again, no pain relief but Chuck's been walking around like a zombie.

    I'll have Chuck check back in when he has had a bit more experience with the two.
  4. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)

    whoops, someone just realized the self incrimination aspect of these forums. someone usually posts on forums as a certain style and this will be a slight adjustment.

    someones brother took 50 mg nucynta last night to review the drug for someone. he has taken oxycontins in the past in the amount of 5-15 mg and has a very very low tolerance. he hasn't taken any opiates in 6 months+. Nucynta did NOTHING! he reported it was akin to a sugar pill. perhaps if the doseages are increased...but still you would expect to feel somewhat different? also had some muscle soreness from the gym which was not alleviated.

    So the verdict on nucynta = fail.
  5. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)

    swim has done nucynta now after being off pain meds for a few weeks. Swims pain is now back at full force. swims brother confessed that he only took half the pill. no wonder it was not effective...

    swim has taken 100 mg and can certainly see why its a schedule II. This is a fairly strong drug. Swim would say its stronger than hydrocone, and about 100 mg feels similar to 7.5-10 mg of oxy. works well for the pain, you definatly get loopy, and you do get a pretty decent euphoria. its more sedative than ultram. much stronger than ultram. fairly typical opiate high...but not exactly. hard to describe. you can think a bit more clearly on this than oxy, but not as clearly as u do on ultram. on empty stomach takes about 20-45 minutes to kick in and then you get that warm feeling in your stomach.

    swim thinks that other people who are complaining about this drug are ones who are on other opiates already and have a higher tolerace...and since this drug isnt a true opiate, its not cross tolerant and therefore people are experiencing withdrawl from their original opiate and confusing it with the effects of nucynta.

    swim is also taking paxilCR 50mg, and trazodone 75mg per night and hasn't noted any seratonin like syndrome effects.

    Swim retracts his statement above and gives it his 100% approval.

  6. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)

    This drug only just came out in June/July Swim believes. Swim thinks for alot of people who have been on pain management for a while, it wouldnt prevent withdrawals of other opiates. however for newer users to pain management, Swim believes it would be fairly effective as the analgesic quality is about 10mg nucynta = 1 mg oxy. 50-100 is what swim has done in one shot and it works very well for swims pain and also produces euphoria, relaxation, and seems to last about 5-6 hours. Swim can see abuse potential with this drug, but so far Swim feels no cravings for it and Swim does have an addictive personality when it comes to opiates(but no other drugs, not even smoking!). Swim has a high pain level with lyme disease, babesia(malarial like co-infection with lyme) and chrons disease. Swim will update this thread as he learns more about being on this drug, potentiating, withdrawals, hangovers, etc


    vin1382 added 1 Minutes and 27 Seconds later...

    PS, swim just popped another 50 pill, and the pain is melting, u can feel that opiate like feel in ur stomach, and swim is feeling good. swim likes
    Last edited: Aug 26, 2009
  7. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)


    So far swim has not had any tolerance build. drug is great for pain and a good feeling drug. not as euphoric as oxy, but you still feel some euphoria, feel very good, and you get the opiate warmth in your legs and body. swim plugged a 50 mg tablet with a percoset 5mg, and both of them potentiate eachother significantly. felt like swim took 30 oxy. took 50 mg nucynta last night, and took 15 mg of percoset and swim was fucking DONE!

    highly recommend trying.

  8. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)

    Another update. Snorting burns like hell!! Quite nasty. But it hits you pretty hard and quickly. Not worth it IMO. So far a mix of a small amount of oxy(5-15mg), and about 75-100 mg of nucynta is AWESOME(tolerant depedent of course.

    Swim brother tried 75 mg and was impressed also.

    Please add experiences to this thread as you get them. swim will add more experiences as he gets them.

  9. dark12

    dark12 Silver Member

    Reputation Points:
    Jan 29, 2008
    Male from U.S.A.
    Re: New Drug Nucynta(Tapentadol)

    Yes, SWIM's pharmacy got this drug in a couple months ago.
    It is a schedule 2 drug which of course means it has a very high potential for abuse.
    Something SWIM found interesting as he was reading the documentation on it was that it is also a reuptake inhibitor of neurepenephrine, which is a quality shared by some anti-depressants. We have had to consult with some patients because of the possibility of a drug interaction if they happened to be taking Nucynta with something like Wellbutrin.
    So far SWIM has only noticed a few scripts for the stuff. It is quite inexpensive considering how new it is. SWIM has noticed the average prescription calls for multiple times per day dosing and usually we dispense over 100 at a time.
  10. onzero

    onzero Silver Member

    Reputation Points:
    Feb 17, 2009
    Male from earth
    Re: New Drug Nucynta(Tapentadol)

    wrong. tapentadol agonizes (activates) mu opioid receptors just like any other opiate. it has additional norepinephrinergic effects however which increase analgesia independent of but synergistic w/ its opiate effects.
  11. vin1382

    vin1382 Silver Member

    Reputation Points:
    Jan 8, 2008
    36 y/o Male
    Re: New Drug Nucynta(Tapentadol)

    swim dont claim to be an expert so you may very well be right. however from what swim read it only antagozies the mu opiod recepters 1/16 of morphine, which seems pretty low. now swim dont know if that is gram by gram, or 50 mg = 1/16 of morphine, etc.

    however in swim experience, and swim have practical experience, swim noted no such cross-over. swim took tapentadol at the same time swim took oxycodone(up to 80 mg , upwards of 6 tapentadol (50 mg each) at a time and varies points of the day. swim recently stopped oxy because swim knew swim was loosing control and went through an incredibly violent withdrawal which had me almost begging god to take swim. one of the worst days of swims life which includes much hardship. swim took 8-9 tapentadol and it did NOTHING at all to ease swim symptoms. if there is cross tolerance, then it is absolutely nothing compared to 80-100 mg a day of oxy, even when taking 8-9(50) gram pills. swim not sure what the conversion is as explained above, but swim know u can substitue other opiates(codeines, hydocodons, hydromorphones, and oxys) and relieve withdrawal symptoms even at lower doses that what you withdrew from. it wont stop some withdrawal, but u can tell theres a difference. This is in swim own experience. swim not preaching, and swim love to hear a scientific answer because there really isnt much on tapentadol yet other than the 1/16 of morphine.

  12. RxSurf

    RxSurf Newbie

    Reputation Points:
    May 5, 2009
    Male from U.S.A.
    Here's some information I found using some drug info software (Micromedex - from Thomsonhc.com). Hope this helps. I can post some more in depth stuff if anyone wants.

    TAPENTADOL (Oral route) - ta-PEN-ta-dol

    Brand Names/Available Dosage Forms
    Some commonly used brand names are:

    In the U.S.A.—

    • Nucynta

    Not commercially available in Canada.

    Therapeutic Class:

    • Analgesic
    Chemical Class:

    • Opioid

    Uses for This Medicine
    Tapentadol is a narcotic analgesic that acts in the central nervous system to relieve moderate or severe pain. If tapentadol is used for a long time, it may become habit-forming (causing mental or physical dependence). Physical dependence may lead to side effects when you stop taking the medicine. Since this medicine is only used for short-term relief of pain, physical dependence will probably not occur.

    This medicine is available only with your doctor's prescription.

    Before Using This Medicine
    In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

    Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

    Appropriate studies have not been performed on the relationship of age to the effects of tapentadol in the pediatric population. Safety and efficacy have not been established.

    Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tapentadol in the elderly. However, elderly patients are more likely to have age-related liver or kidney problems, which may require an adjustment in the dose for patients receiving tapentadol.


    Pregnancy CategoryExplanationAll TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.Lactation—
    There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

    Interactions with Medicines—
    Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

    • Brofaromine
    • Clorgyline
    • Furazolidone
    • Iproniazid
    • Isocarboxazid
    • Lazabemide
    • Linezolid
    • Moclobemide
    • Nialamide
    • Pargyline
    • Phenelzine
    • Procarbazine
    • Rasagiline
    • Selegiline
    • Toloxatone
    • Tranylcypromine
    Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

    • Alfentanil
    • Almotriptan
    • Alprazolam
    • Amitriptyline
    • Amoxapine
    • Anileridine
    • Buprenorphine
    • Buspirone
    • Butabarbital
    • Butorphanol
    • Chlordiazepoxide
    • Chlorpromazine
    • Citalopram
    • Clomipramine
    • Clonazepam
    • Clorazepate
    • Codeine
    • Desipramine
    • Desvenlafaxine
    • Dexmedetomidine
    • Dezocine
    • Diazepam
    • Difenoxin
    • Dihydrocodeine
    • Diphenhydramine
    • Diphenoxylate
    • Dothiepin
    • Doxepin
    • Doxylamine
    • Duloxetine
    • Eletriptan
    • Escitalopram
    • Estazolam
    • Eszopiclone
    • Ethchlorvynol
    • Fentanyl
    • Flumazenil
    • Fluoxetine
    • Fluphenazine
    • Flurazepam
    • Fluvoxamine
    • Frovatriptan
    • Halazepam
    • Hydrocodone
    • Hydromorphone
    • Hydroxyzine
    • Imipramine
    • Levomethadyl
    • Levorphanol
    • Lofepramine
    • Lorazepam
    • Meperidine
    • Meprobamate
    • Methadone
    • Midazolam
    • Milnacipran
    • Morphine
    • Morphine Sulfate Liposome
    • Nalbuphine
    • Naratriptan
    • Nefazodone
    • Nortriptyline
    • Oxazepam
    • Oxycodone
    • Oxymorphone
    • Paroxetine
    • Pentazocine
    • Pentobarbital
    • Perphenazine
    • Phenobarbital
    • Prazepam
    • Prochlorperazine
    • Promethazine
    • Propofol
    • Propoxyphene
    • Protriptyline
    • Quazepam
    • Ramelteon
    • Remifentanil
    • Rizatriptan
    • Secobarbital
    • Sertraline
    • Sufentanil
    • Sumatriptan
    • Temazepam
    • Thioridazine
    • Tramadol
    • Triazolam
    • Trifluoperazine
    • Trimipramine
    • Venlafaxine
    • Zaleplon
    • Zolmitriptan
    • Zolpidem
    Interactions with Food/Tobacco/Alcohol—
    Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

    Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

    • Ethanol
    Other Medical Problems—
    The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

    • Alcohol abuse, history of or
    • Drug abuse or dependence, history of—Physical dependence on tapentadol may be more likely to develop.

    • Bowel blockage (e.g., paralytic ileus) or
    • Kidney disease, severe or
    • Liver disease, severe or
    • Lung disease (e.g., asthma or hypercapnia), severe—Should not be used in patients with these conditions.

    • Brain tumor or head injury, history of or
    • Breathing or other lung problems (e.g., chronic obstructive pulmonary disease [COPD], hypoxia, or sleep apnea) or
    • Depression, history of or
    • Gallbladder problems or
    • Kyphoscoliosis (severe curvature of the spine that can cause breathing problems) or
    • Pancreatitis (inflammation of the pancreas) or
    • Seizures or epilepsy, history of or
    • Underactive thyroid—Use with caution. May make these conditions worse.

    • Liver disease—Use with caution. The effects may be increased because of slower removal from the body.

    Proper Use of This Medicine
    Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects and the chances of abuse.

    This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

    You may take this medicine with or without food.

    • For oral dosage form (tablets):
      • For pain:
        • Adults—50 to 100 milligrams (mg) every 4 to 6 hours. Your doctor may adjust your dose if needed.
        • Children—Use and dose must be determined by your doctor.

    Missed Dose—
    If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

    Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

    Keep out of the reach of children.

    Do not keep outdated medicine or medicine no longer needed.

    Ask your healthcare professional how you should dispose of any medicine you do not use.

    Precautions While Using This Medicine
    It is very important that your doctor check your progress at regular visits to make sure the medicine is working properly and to check for any unwanted effects.

    You should not use this medicine if you have used an MAO inhibitor (MAOI) such as isocarboxazid, phenelzine, selegiline, tranylcypromine, Eldepryl®, Marplan®, Nardil®, or Parnate® within the past 14 days.

    This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants. CNS depressants are medicines that slow down the nervous system and may cause drowsiness. Some examples of CNS depressants are antihistamines or medicines for hay fever or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicines including other narcotics; barbiturates; medicines for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using tapentadol.

    This medicine may cause some people to become dizzy, lightheaded, faint, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Getting up slowly from a lying or sitting position may also help.

    Make sure your doctor knows about all the other medicines you are using. This medicine may cause a serious condition called serotonin syndrome. This is more likely to occur when it is taken with certain medicines for depression (e.g., amitriptyline, doxepin, fluoxetine, nortriptyline, paroxetine, Celexa®, Effexor®, Elavil®, Lexapro™, Pamelor®, Paxil®, Sinequan®, or Zoloft®), pain (e.g., tramadol [e.g., Ultram®]), or migraine headaches (sumatriptan [e.g., Imitrex®], zolmitriptan [e.g., Zomig®], or rizatriptan [e.g., Maxalt®]). Check with your doctor first before taking any other medicines.

    Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as anxiety, diarrhea, headache, nausea, shivering, sweating, tremors, or trouble with sleeping.

    Side Effects of This Medicine
    Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur:

    • Less common
      • Bladder pain; bloody or cloudy urine; body aches or pain; chills; cough; difficult, burning, or painful urination; difficulty in breathing; ear congestion; fever; frequent urge to urinate; headache; loss of voice; lower back or side pain; muscle aches; nasal congestion; runny nose; sneezing; sore throat; stuffy or runny nose; unusual tiredness or weakness

    • Rare
      • Anxiety; being forgetful; burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings; changes in patterns and rhythms of speech; clumsiness or unsteadiness; confusion; confusion about identity, place, and time; convulsions; delusions; dementia; drowsiness; dry mouth; fainting; false or unusual sense of well-being; fast heartbeat; feeling drunk; hives; hoarseness; hyperventilation; irregular heartbeats; irregular, fast, slow, or shallow breathing; irritability; itching; joint pain, stiffness, or swelling; nervousness; pale or blue lips, fingernails, or skin; rash; redness of the skin; relaxed and calm; restlessness; sensation of heaviness; shakiness and unsteady walk; shortness of breath; sleepiness; slurred speech; swelling; swelling of the eyelids, face, lips, hands, or feet; tightness in the chest; trouble in speaking; trouble with sleeping; troubled breathing or swallowing; unsteadiness, trembling, or other problems with muscle control or coordination; wheezing

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    • More common
      • Constipation; dizziness; nausea; sleepiness or unusual drowsiness; vomiting

    • Less common
      • Abnormal dreams; acid or sour stomach; belching; decreased appetite; difficulty in moving; feeling hot; feeling of warmth; heartburn; increased sweating; indigestion; muscle pain or stiffness; rash; redness of the face, neck, arms, and occasionally, upper chest; sleeplessness; stomach discomfort, upset, or pain; sudden sweating; unable to sleep; unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

    • Rare
      • Blurred or loss of vision; disturbed color perception; double vision; halos around lights; night blindness; overbright appearance of lights; tunnel vision

    Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

    Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

    Portions of this document were updated on 10/16/06

    RxSurf added 29 Minutes and 59 Seconds later...

    How come I cannot post the rest of the information? I removed all the links from this one...
    Last edited: Dec 19, 2009
  13. ForcedZen

    ForcedZen Silver Member

    Reputation Points:
    Dec 14, 2009
    34 y/o Male from U.S.A.
    SWIM was not impressed with tapentadol, but he was limited to a dose of only 50mg. Some pain relief and mood lift were noticeable, but no more than maybe 2.5mg of hydrocodone. SWIM would like to try it again, with a dosage of perhaps 150mg.
  14. dusman81

    dusman81 Newbie

    Reputation Points:
    Feb 19, 2010
    It occurs to swim that tapentadol would have a less euphoric quality than the conventional opioids, because tapentadol is chemically and structuaraly simmilar to tramadol. As such tapentadol has mu agonist and norepinephrine re-uptake inhibitional qualities. Swim is definatly not an expert, but then again swim is not a novice. Swim also wants to note that according to medical literature, doses of tapentadol P.O. over 300 milligrams is considered a moderatly high to high dose, and is not recommended for patients whom are opioid naive. Be safe.
  15. Opana2Subs

    Opana2Subs Silver Member

    Reputation Points:
    Mar 13, 2010
    A friend of mine insufflated 3, 8mg dilaudid throughout the course of the day today, with the last one being used between 12 & 1 p.m.

    Fast forward to 3 p.m. my friend received a 100 mg Nucynta. After researching this new drug he found out that it burned severely when insufflated, yet decided to try just a little bit nasally and yes, it does burn like hell, but the burn lasts only around 5 minutes or so. He layed out another bump of said product and attempted to insufflate again. After only getting through about 1/4 of the bump he decided that the burn was not worth the reward.

    My friend also works on military models and has a very slight cut on the finger he used to put the rest of the powdered Nucynta into his mouth. The powder apparently burned his finger once getting into the minor cut. Upon the powder entering his mouth he explained that it was very bitter tasting. He thinks he might be feeling the affects of the drug, but is not sure since he knows he still has the Dilaudid in his system. Since he is unsure of the potency of the Nucynta he is going to wait until he feels slightly uncomfortable w/d's before dosing again.

    As of right now he's saying that its easy for his eyes to go out-of-focus, yet also easy to keep them from being out-of-focus. He feels slightly euphoric, and a bit spaced out. Apparently its very easy to just stare off into space without a thought in his head. His knee pain is almost non-existent along with his lower back pain as well. He is also complaining of a slight headache, but that could be caused by smoking too many cigarettes along with him not eating at all today.

    I asked if he would let me know if the Nucynta relieves him of his w/d's tomorrow morning so that I could relay the information into this thread.

    Opana2Subs added 1141 Minutes and 10 Seconds later...

    I was told this morning by my friend that Nucynta does in fact stave off W/D's.

    He is 6'2" 185 lbs

    He took 2 doses @ 100 mg each, one around 5 a.m. and another around 9 a.m. both doses were taken orally.

    The main affects seem to last 2-3 hours

    Main affects; Little to no pain in his knees and back, body is exhausted

    Side Affects; Very vivid and unpleasant dreams, woke up several times during the night in a cold sweat, clothes, bedsheets and blanket were all damp with sweat. finds it difficult to concentrate, forgets what he is doing. He said he went for coffee and stood in the doorway to the kitchen for a few minutes before remembering what he went to the kitchen for. Then after making the coffe and returning to his bedroom the coffee had gotten cold, he didn;t drink one sip. No appetite. Eyes are sensitive to light. does not want to do anything though he has much to do. Nothing is entertaining enough to occupy his mind, has no ambition to work on his hobbies, housework or walking the dogs, nothing on TV interests him. Wants to be alone. Feels very "slowed-down"

    Experience rating; Says he would probably be better off with his Subs, but when taking only Subs he feel a lot of anxiety. There is no anxiety with Nucynta, he doenst feel good or bad, he feels empty and indifferent.

    I don't expect to see people buying this drug for its euphoric affects, it does kill pain, though the feelings of emptiness and loss of ambition override its painkilling qualities. Might be better taken in conjunction with an XR type of drug such as Opana ER, or Trans-dermal Fentanyl. Or possibly some sort of anti-depressant.

    Valuable info; Refuse it if your current meds are tolerable, useful for mitigating W/D's and pain relief, but again, there is little to no euphoria and it is my friends opinion that abusing or taking more than normally directed will more than likely increase its depressive affects.
    The depressive affects do not constitute thoughts or feelings of suicide or self-pity, depressive as in slowing down the user in an uncomfortable way, also had to focus on his breathing. He apparently fell alseep fast which he said was nice since he doesn't sleep well to begin with, but he did not sleep all the way through the night. Every time he was awoken by a dream, he cut off a small piece of the 100mg Nucynta and swallowed it to get back to bed.

    He has taken many different types of opiod medication ranging from Opana,Oxies,Morphine Sulfate, Fentanyl (patches and suckers) Hydromorphone, Vics, Valium, and xanex. Most of these produce euphoria AND pain suppression with exception to the Xanex and Val.

    Opana,Oxies, etc. > Nucynta.

    Though some might find it useful for pain management, my friend says its not worht the trade-off.

    Opana2Subs added 144 Minutes and 18 Seconds later...

    My friend Matoosh just called a bit ago saying that he is feeling better now since he put a small strip of a 100 mcg Fentanyl patch behind his lower lip with the sticky side facing outward.
    Within 15 minutes Matoosh said he's feeling better. He says he is very surprised regarding the improvement of how he feels, no longer feeling run down and exhausted, he plans on getting his yard-work done. His headache is gone as well. He compared the Nucynta affects to that of the flue. Saying that he had minor body aches along with all the other symptoms, but after administering the Fentanyl, all is well. He says the next two weeks are going to suck with this Nucynta, and is looking forward to getting a change in scripts.

    *3dfunk said*
    Within minutes, Chuck said that he felt awful! Very dizzy, very lightheaded but most of all, a very vivid sence of not being in the room. Chuck would do something and 2 seconds later, Chuck said he was questioning if he'd done it in the first place. Couldn't remember some of the things he had said and would come out of conversations feeling completely out of the loop.

    Matoosh was feeling quite similar. The more you take the worse it gets. I told Matoosh only to take enough so as not to be dopesick. Matoosh asked me if Xanex would be a poor choice to make a cocktail with. I told him, "Well, if the Nucynta makes you feel all run down and exhausted, wouldn't you expect that to be intensified by adding Xanex"?
    He said I was probably right, but I was wondering what you all think?
    Last edited: Apr 14, 2010
  16. Opana2Subs

    Opana2Subs Silver Member

    Reputation Points:
    Mar 13, 2010
    Matoosh called me again today to tell me that Nucynta DOES NOT stave off w/ds. He awoke this morning feeling dopesick. He had nothing but Nucynta and Xanax. Matoosh took 200 mg Nucynta hoping it would ease W/Ds. He still felt W/Ds, only now he was feeling W/Ds AND loopy from the Nucynta. He decided to take two .\5 mg xanax hoping it would just knock him out. That combination DID knock him out, but upon waking up Matoosh was sick again.

    Matoosh did not want to take ANY MORE Nucynta so he took a risk and administered 2 mg Suboxone sublingually. After a little more than an hour, Matoosh reports his w/d symptoms are going away. He says he still doesnt feel quite right at the moment, suffering from a bit of anxiety; an uneasy stomach; and a bit spaced out.

    Matoosh at first assumed that Nucynta would help in doing away with W/Ds. But now realizes that by taking alot of Nucynta and xanax all he did was go to sleep.

    Nucynta will not prevent withdrawals fromh opiates if used alone
    As for Matoosh, he says by taking 200 mg Nucynta in conjunction with xanax you can get yourself to sleep.

    Matoosh would also like to point out that after taking the Nucynta in the morning, he waited SEVEN hours before taking Suboxone. Matoosh DID NOT experience precipitated withdrawal symptoms. The Suboxone suppressed the physical W/Ds even though he had taken Nucynta earlier in the day.

    This is strange to Matoosh since he figured that Nucynta is an opiate, he thought he should have felt sicker after taking the Suboxone.
  17. CRP_00

    CRP_00 Newbie

    Reputation Points:
    Jun 21, 2010
    Hello out there!

    Im new to this site, which has been very helpful by the way, thanks to everyone posting their experiences! :vibes:

    I'm a little behind the times and just heard about the new opiate Nucynta and was wondering if anybody knew or had experiences with this drug in terms of building a tolerance to it and needing to take more, or the possibility of becoming addicted to it like percosets or vicodins?

    An y help would be much apreciated!

    Thanks! :applause:
  18. diotro

    diotro Newbie

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    Feb 19, 2009
    Male from U.S.A.
    Swim took 250mg (5 x 50mg) and would say that it's quite comparable to Tramadol, although there is a slight "energy enhancement" due to it's NRI properties.

    Not as euphoric as say a Percocet or a Vicodin, but hey, the threshold for dosages goes all the way up to 600mg, in a day. Maybe I need a bigger dose to gain more a euphoric punch?
  19. brendanjames

    brendanjames Newbie

    Reputation Points:
    Jun 25, 2009
    Male from U.S.A.
    a friend of mine just got some today. he is an iv user, and tried it out. he sucked off the coating like the old oxy 80? and did the usual procedure in IVing. no need for flame. just sakes a minute to breakdown in the water.

    i watched my friend take this shot, and he was blown away by the rush.

    and as a side note, my friend is a very regular opiate user.

    brendanjames added 2 Minutes and 24 Seconds later...


    sorry im a big time lurker so i cant edit, notice iv'e been on the site over two years this post being my tenth
    Last edited: Jul 24, 2011
  20. Burning Pain

    Burning Pain Newbie

    Reputation Points:
    Sep 8, 2011
    Male from U.S.A.
    Doctor just switched me to Nucynta in place of Exalgo (hydromorphone) today. I was wondering how it compares to managing pain and if I should expect a "high" or not. I had developed a tolerance for oxycodone and it did very little for the pain, I was only taking it to prevent withdrawal in the end. Dilaudid helped the pain much better for me than oxy ever did but the exalgo was showing up in the toilet still full of medication. I wondered if my taking nexium for heartburn caused it not to dissolve from lowered stomach acid or something. Does anyone here know about that?

    My biggest problem with the dilaudid is that the dosage is 4-6 times daily with a maximum of 4 per day and I was always running out of them a couple days before my next Dr apt. This caused horrible withdrawal symptoms. Dilaudid works well for me right now but they never give me enough pills. I want to know if the Nucynta will prevent withdrawal symptoms If I stop taking the Dilaudid. Avinza did that for me if I ran out of Oxycodone but didn't work at all for breakthrough pain relief. I try to ask my doctor things like this but his English is poor and I seldom understand him for things like that.

    I can say that the Dilaudid and Nucynta taken together did excellent work of alleviating both my neck pain and second day withdrawal symptoms. If it continues to work as well as today and tolerance doesn't come on too soon, I'm sold on it. A much needed improvement over that expensive junk Exalgo that my body can't seem to leach any of it through that tiny hole in the plastic coating.

    Thanks for all the good advice/experience/warnings, you have no idea how scared I am of withdrawal.
    Last edited by a moderator: Jan 29, 2017